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Past and future of Ga-citrate for infection and inflammation imaging.
Both 67Ga and 68Ga-citrates are used to detect a wide spectrum of pathology consisting of various inflammatory, infectious and malignant conditions. Considering the now widespread availability and constantly increasing demand for PET/CT studies,68Ga-citrate is gaining ground in clinical settings and the added value of combined metabolic and anatomical imaging achieved by combining PET with computed tomography (CT) to PET/CT makes 68Ga-citrate particularly promising. Despite the tracer's non-specificity, it has demonstrated potential especially in the evaluation of various infectious and inflammatory skeletal- and lung conditions. In this review, we will focus on the indications and lessons learned from 67Ga, and present the current status for the use of 68Ga-citrate PET/CT in selected inflammation and infectious diseases based on the limited literature available.
University of Pretoria, Department of Nuclear Medicine, Steve Biko Academic Hospital. South Africa.,
Cambridge University Hospitals , Cambridge University. United Kingdom.,
Cambridge University Hospitals , Cambridge University. United Kingdom.
University of Pretoria, Department of Nuclear Medicine, Steve Biko Academic Hospital. South Africa.
Pub Type(s)Journal Article