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Past and Future of Ga-citrate for Infection and Inflammation Imaging.

Abstract

Both 67Ga and 68Ga-citrates are used to detect a wide spectrum of pathology consisting of various inflammatory, infectious and malignant conditions. Considering the now widespread availability and constantly increasing demand for PET/CT studies,68Ga-citrate is gaining ground in clinical settings and the added value of combined metabolic and anatomical imaging achieved by combining PET with Computed Tomography (CT) to PET/CT makes 68Ga-citrate particularly promising. Despite the tracer's non-specificity, it has demonstrated potential especially in the evaluation of various infectious and inflammatory skeletal- and lung conditions. In this review, we will focus on the indications and lessons learned from 67Ga, and present the current status for the use of 68Ga-citrate PET/CT in selected inflammation and infectious diseases based on the limited literature available.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nuclear Medicine, University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa.

    ,

    Department of Nuclear Medicine, University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa. Cambridge University Hospitals, Cambridge University, United Kingdom.

    ,

    Cambridge University Hospitals, Cambridge University, United Kingdom.

    Department of Nuclear Medicine, University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa.

    Source

    Current pharmaceutical design 24:7 2018 pg 787-794

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29189131

    Citation

    TY - JOUR T1 - Past and Future of Ga-citrate for Infection and Inflammation Imaging. AU - Vorster,Mariza, AU - Buscombe,John, AU - Saad,Ziauddin, AU - Sathekge,Mike, PY - 2017/05/01/received PY - 2017/10/01/revised PY - 2017/11/01/accepted PY - 2017/12/1/pubmed PY - 2017/12/1/medline PY - 2017/12/1/entrez KW - 68Ga-citrate KW - Computed Tomography (CT) KW - Gallium KW - infection KW - inflammation KW - malignant conditions. SP - 787 EP - 794 JF - Current pharmaceutical design JO - Curr. Pharm. Des. VL - 24 IS - 7 N2 - Both 67Ga and 68Ga-citrates are used to detect a wide spectrum of pathology consisting of various inflammatory, infectious and malignant conditions. Considering the now widespread availability and constantly increasing demand for PET/CT studies,68Ga-citrate is gaining ground in clinical settings and the added value of combined metabolic and anatomical imaging achieved by combining PET with Computed Tomography (CT) to PET/CT makes 68Ga-citrate particularly promising. Despite the tracer's non-specificity, it has demonstrated potential especially in the evaluation of various infectious and inflammatory skeletal- and lung conditions. In this review, we will focus on the indications and lessons learned from 67Ga, and present the current status for the use of 68Ga-citrate PET/CT in selected inflammation and infectious diseases based on the limited literature available. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/29189131/Past_and_future_of_Ga-citrate_for_infection_and_inflammation_imaging. L2 - http://www.eurekaselect.com/157864/article ER -