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Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis.

Abstract

BACKGROUND

Atopic Dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM).

OBJECTIVE

This article reviews the pathophysiology of AD, clinical trials and recent patents involving various modalities of CAM in the treatment of AD.

METHODS

A Medline/Pubmed search was conducted using Clinical Queries with the key terms "Chinese Medicine OR Complementary and Alternative medicine" AND "Eczema OR Atopic dermatitis". The search strategy included meta-analyses, Randomized Controlled Trials (RCTs), clinical trials, reviews and pertinent references. Patents were searched using the key term "atopic dermatitis" from www.google.com/patents, www.uspto.gov, and www.freepatentsonline.com.

RESULTS

Only a few RCTs evaluated the efficacy of Chinese medicinal herbs in treating AD. There was some evidence for other modalities of CAM. Integrative Medicine (IM) usually refers to the various forms of CAM that combine conventional western medicine and Chinese medicine. Supporting evidence for the efficacy of IM in the treatment of AD is presently lacking. Integration is difficult. Western medicine practitioners are often ignorant about CAM and IM. Parents are concerned about the potential side effects of Western medicine and will tend to be non-compliant with the conventional Western component of IM. Recent patents on CAM and IM are reviewed. Most CAM patents are herbal compositions, evidence on their efficacy is generally lacking.

CONCLUSION

AD is a complex disease. The psychodynamics of the child and his/her family is the reason for the often suboptimal outcomes. Both Western and CAM practitioners should collaborate to create a mutually encouraging environment for the advances of IM. CAM and IM publications and patents are reviewed. Evidence of their efficacy is generally lacking. Further research is needed.

Authors+Show Affiliations

Department of Paediatrics, the Chinese University of Hong Kong. Hong Kong.Department of Paediatrics, the University of Calgary and the Alberta Children's Hospital, Calgary, Alberta. Canada.Department of Paediatrics and Adolescent Medicine, The University of Hong Kong. Hong Kong.School of Pharmacy, The Chinese University of Hong Kong. Hong Kong.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29189188

Citation

Hon, Kam Lun, et al. "Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis." Recent Patents On Inflammation & Allergy Drug Discovery, vol. 11, no. 2, 2017, pp. 114-124.
Hon KL, Leung AKC, Leung TNH, et al. Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis. Recent Pat Inflamm Allergy Drug Discov. 2017;11(2):114-124.
Hon, K. L., Leung, A. K. C., Leung, T. N. H., & Lee, V. W. Y. (2017). Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis. Recent Patents On Inflammation & Allergy Drug Discovery, 11(2), 114-124. https://doi.org/10.2174/1872213X11666171128142333
Hon KL, et al. Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis. Recent Pat Inflamm Allergy Drug Discov. 2017;11(2):114-124. PubMed PMID: 29189188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis. AU - Hon,Kam Lun, AU - Leung,Alexander K C, AU - Leung,Theresa N H, AU - Lee,Vivian W Y, PY - 2017/10/03/received PY - 2017/11/21/revised PY - 2017/11/21/accepted PY - 2017/12/1/pubmed PY - 2018/8/3/medline PY - 2017/12/1/entrez KW - Alternative medicine KW - Chinese herbal medicine KW - atopic dermatitis KW - complementary medicine KW - eczema KW - integrative medicine KW - pathogenesis. SP - 114 EP - 124 JF - Recent patents on inflammation & allergy drug discovery JO - Recent Pat Inflamm Allergy Drug Discov VL - 11 IS - 2 N2 - BACKGROUND: Atopic Dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM). OBJECTIVE: This article reviews the pathophysiology of AD, clinical trials and recent patents involving various modalities of CAM in the treatment of AD. METHODS: A Medline/Pubmed search was conducted using Clinical Queries with the key terms "Chinese Medicine OR Complementary and Alternative medicine" AND "Eczema OR Atopic dermatitis". The search strategy included meta-analyses, Randomized Controlled Trials (RCTs), clinical trials, reviews and pertinent references. Patents were searched using the key term "atopic dermatitis" from www.google.com/patents, www.uspto.gov, and www.freepatentsonline.com. RESULTS: Only a few RCTs evaluated the efficacy of Chinese medicinal herbs in treating AD. There was some evidence for other modalities of CAM. Integrative Medicine (IM) usually refers to the various forms of CAM that combine conventional western medicine and Chinese medicine. Supporting evidence for the efficacy of IM in the treatment of AD is presently lacking. Integration is difficult. Western medicine practitioners are often ignorant about CAM and IM. Parents are concerned about the potential side effects of Western medicine and will tend to be non-compliant with the conventional Western component of IM. Recent patents on CAM and IM are reviewed. Most CAM patents are herbal compositions, evidence on their efficacy is generally lacking. CONCLUSION: AD is a complex disease. The psychodynamics of the child and his/her family is the reason for the often suboptimal outcomes. Both Western and CAM practitioners should collaborate to create a mutually encouraging environment for the advances of IM. CAM and IM publications and patents are reviewed. Evidence of their efficacy is generally lacking. Further research is needed. SN - 1872-213X UR - https://www.unboundmedicine.com/medline/citation/29189188/Complementary_Alternative_and_Integrative_Medicine_for_Childhood_Atopic_Dermatitis_ L2 - http://www.eurekaselect.com/157791/article DB - PRIME DP - Unbound Medicine ER -