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Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia.
Arch Clin Neuropsychol. 2018 Nov 01; 33(7):795-807.AC

Abstract

Objective

The ability to carry out instrumental activities (IADL) of daily living allows older adults to continue to live independently. Previous research suggested IADL were supported by multiple cognitive and neuropsychiatric factors. The primary goal of this study was to investigate whether immediate memory, executive functions, depression, and apathy, predicted unique variance in IADL over and above demographic variables (age and education) and general cognitive screening (Mini-Mental State Exam).

Method

Participants (N = 403) were recruited from the Rural and Remote Memory Clinic (75 no cognitive impairment; 75 mild cognitive impairment; 139 dementia due to Alzheimer's disease; 114 non-Alzheimer's dementia).

Results

Results of hierarchical regression analyses suggested immediate memory, executive functions, apathy, and depression each accounted for unique variance in IADL in the overall sample, but as a predictor only apathy predicted variance in IADLs above demographics and general cognitive status. Further analysis of the diagnostic subgroups suggested different variables were more strongly associated with IADL from group to group (apathy and depression for normal participants, apathy for MCI participants and for participants with dementia due to AD, but not for those with non-AD dementia).

Conclusions

The implications for developing cognitive rehabilitation interventions are discussed, with a recommendation for interventions for symptoms of apathy.

Authors+Show Affiliations

Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan.Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan.Canadian Centre for Health and Safety in Agriculture, Medicine, University of Saskatchewan, Saskatoon, Saskatchewan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29190312

Citation

Burton, Rachel L., et al. "Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia." Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists, vol. 33, no. 7, 2018, pp. 795-807.
Burton RL, O'Connell ME, Morgan DG. Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia. Arch Clin Neuropsychol. 2018;33(7):795-807.
Burton, R. L., O'Connell, M. E., & Morgan, D. G. (2018). Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia. Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists, 33(7), 795-807. https://doi.org/10.1093/arclin/acx112
Burton RL, O'Connell ME, Morgan DG. Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia. Arch Clin Neuropsychol. 2018 Nov 1;33(7):795-807. PubMed PMID: 29190312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia. AU - Burton,Rachel L, AU - O'Connell,Megan E, AU - Morgan,Debra G, PY - 2016/12/19/received PY - 2017/11/07/accepted PY - 2017/12/1/pubmed PY - 2019/6/6/medline PY - 2017/12/1/entrez SP - 795 EP - 807 JF - Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists JO - Arch Clin Neuropsychol VL - 33 IS - 7 N2 - Objective: The ability to carry out instrumental activities (IADL) of daily living allows older adults to continue to live independently. Previous research suggested IADL were supported by multiple cognitive and neuropsychiatric factors. The primary goal of this study was to investigate whether immediate memory, executive functions, depression, and apathy, predicted unique variance in IADL over and above demographic variables (age and education) and general cognitive screening (Mini-Mental State Exam). Method: Participants (N = 403) were recruited from the Rural and Remote Memory Clinic (75 no cognitive impairment; 75 mild cognitive impairment; 139 dementia due to Alzheimer's disease; 114 non-Alzheimer's dementia). Results: Results of hierarchical regression analyses suggested immediate memory, executive functions, apathy, and depression each accounted for unique variance in IADL in the overall sample, but as a predictor only apathy predicted variance in IADLs above demographics and general cognitive status. Further analysis of the diagnostic subgroups suggested different variables were more strongly associated with IADL from group to group (apathy and depression for normal participants, apathy for MCI participants and for participants with dementia due to AD, but not for those with non-AD dementia). Conclusions: The implications for developing cognitive rehabilitation interventions are discussed, with a recommendation for interventions for symptoms of apathy. SN - 1873-5843 UR - https://www.unboundmedicine.com/medline/citation/29190312/Cognitive_and_Neuropsychiatric_Correlates_of_Functional_Impairment_Across_the_Continuum_of_No_Cognitive_Impairment_to_Dementia_ L2 - https://academic.oup.com/acn/article-lookup/doi/10.1093/arclin/acx112 DB - PRIME DP - Unbound Medicine ER -