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Genome Editing: The Recent History and Perspective in Cardiovascular Diseases.
J Am Coll Cardiol. 2017 Dec 05; 70(22):2808-2821.JACC

Abstract

The genome-editing field has advanced to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyopathy gene mutation in viable human embryos. In this review, the author discusses the basic principles of genome editing, recent advances in clustered regularly interspaced short palindromic repeats and clustered regularly interspaced short palindromic repeats-associated 9 technology, the impact on cardiovascular basic science research, possible therapeutic applications in patients with cardiovascular diseases, and finally the implications of potential clinical uses of human germline genome editing.

Authors+Show Affiliations

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and the Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: kiranmusunuru@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29191331

Citation

Musunuru, Kiran. "Genome Editing: the Recent History and Perspective in Cardiovascular Diseases." Journal of the American College of Cardiology, vol. 70, no. 22, 2017, pp. 2808-2821.
Musunuru K. Genome Editing: The Recent History and Perspective in Cardiovascular Diseases. J Am Coll Cardiol. 2017;70(22):2808-2821.
Musunuru, K. (2017). Genome Editing: The Recent History and Perspective in Cardiovascular Diseases. Journal of the American College of Cardiology, 70(22), 2808-2821. https://doi.org/10.1016/j.jacc.2017.10.002
Musunuru K. Genome Editing: the Recent History and Perspective in Cardiovascular Diseases. J Am Coll Cardiol. 2017 Dec 5;70(22):2808-2821. PubMed PMID: 29191331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome Editing: The Recent History and Perspective in Cardiovascular Diseases. A1 - Musunuru,Kiran, PY - 2017/08/20/received PY - 2017/10/02/revised PY - 2017/10/03/accepted PY - 2017/12/2/entrez PY - 2017/12/2/pubmed PY - 2017/12/6/medline KW - CRISPR KW - Cas9 KW - gene therapy KW - genetics KW - genomics SP - 2808 EP - 2821 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 70 IS - 22 N2 - The genome-editing field has advanced to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyopathy gene mutation in viable human embryos. In this review, the author discusses the basic principles of genome editing, recent advances in clustered regularly interspaced short palindromic repeats and clustered regularly interspaced short palindromic repeats-associated 9 technology, the impact on cardiovascular basic science research, possible therapeutic applications in patients with cardiovascular diseases, and finally the implications of potential clinical uses of human germline genome editing. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/29191331/Genome_Editing:_The_Recent_History_and_Perspective_in_Cardiovascular_Diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(17)41054-0 DB - PRIME DP - Unbound Medicine ER -