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Chikungunya Virus: Pathophysiology, Mechanism, and Modeling.

Abstract

Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic waves. In the past decade and a half, the disease has resurged in several countries around the globe, with outbreaks becoming increasingly severe. Though CHIKV was first isolated in 1952, there remain significant gaps in knowledge of CHIKV biology, pathogenesis, transmission, and mechanism. Diagnosis is largely simplified and based on symptoms, while treatment is supportive rather than curative. Here we present an overview of the disease, the challenges that lie ahead for future research, and what directions current studies are headed towards, with emphasis on improvement of current animal models and potential use of 3D models.

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  • Authors+Show Affiliations

    ,

    Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA. vaishnavi.ganesan@unmc.edu.

    ,

    Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA. bin.duan@unmc.edu. Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. bin.duan@unmc.edu. Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. bin.duan@unmc.edu.

    Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. patrick.reid@unmc.edu.

    Source

    Viruses 9:12 2017 12 01 pg

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    29194359