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Studies of neutrophil chemotactic factor of anaphylaxis in metabisulfite sensitivity.
Ann Allergy 1989; 62(2):117-21AA

Abstract

The mechanism(s) of adverse reactions to sulfites remains unclear. To determine whether mast cell degranulation is involved in sulfite sensitivity, we performed single-blind, placebo-controlled oral aqueous challenges with potassium metabisulfite in 13 patients with histories suggestive of sulfite sensitivity. Ten patients were also skin tested with potassium metabisulfite at 10 mg/mL and all had negative reactions. Serum samples were obtained from all the patients before the challenge and for 180 minutes after the challenge. The samples were tested for the presence of neutrophil chemotactic factor of anaphylaxis, using both a 51chromium microchamber chemotaxis assay and a leukocyte polarization technique. Six of 13 patients had positive challenges as defined by a fall equal to or greater than 20% in their forced expiratory volume in one second. No significant increase in neutrophil chemotactic factor activity was detected in the postchallenge serum samples from patients who experienced positive or negative challenges. We conclude that sensitivity to aqueous metabisulfite is not associated with mast cell degranulation in metabisulfite skin test-negative patients.

Authors+Show Affiliations

Department of Medicine, University of Washington School of Medicine, Seattle.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2919798

Citation

Sprenger, J D., et al. "Studies of Neutrophil Chemotactic Factor of Anaphylaxis in Metabisulfite Sensitivity." Annals of Allergy, vol. 62, no. 2, 1989, pp. 117-21.
Sprenger JD, Altman LC, Marshall SG, et al. Studies of neutrophil chemotactic factor of anaphylaxis in metabisulfite sensitivity. Ann Allergy. 1989;62(2):117-21.
Sprenger, J. D., Altman, L. C., Marshall, S. G., Pierson, W. E., & Koenig, J. Q. (1989). Studies of neutrophil chemotactic factor of anaphylaxis in metabisulfite sensitivity. Annals of Allergy, 62(2), pp. 117-21.
Sprenger JD, et al. Studies of Neutrophil Chemotactic Factor of Anaphylaxis in Metabisulfite Sensitivity. Ann Allergy. 1989;62(2):117-21. PubMed PMID: 2919798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies of neutrophil chemotactic factor of anaphylaxis in metabisulfite sensitivity. AU - Sprenger,J D, AU - Altman,L C, AU - Marshall,S G, AU - Pierson,W E, AU - Koenig,J Q, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 117 EP - 21 JF - Annals of allergy JO - Ann Allergy VL - 62 IS - 2 N2 - The mechanism(s) of adverse reactions to sulfites remains unclear. To determine whether mast cell degranulation is involved in sulfite sensitivity, we performed single-blind, placebo-controlled oral aqueous challenges with potassium metabisulfite in 13 patients with histories suggestive of sulfite sensitivity. Ten patients were also skin tested with potassium metabisulfite at 10 mg/mL and all had negative reactions. Serum samples were obtained from all the patients before the challenge and for 180 minutes after the challenge. The samples were tested for the presence of neutrophil chemotactic factor of anaphylaxis, using both a 51chromium microchamber chemotaxis assay and a leukocyte polarization technique. Six of 13 patients had positive challenges as defined by a fall equal to or greater than 20% in their forced expiratory volume in one second. No significant increase in neutrophil chemotactic factor activity was detected in the postchallenge serum samples from patients who experienced positive or negative challenges. We conclude that sensitivity to aqueous metabisulfite is not associated with mast cell degranulation in metabisulfite skin test-negative patients. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/2919798/Studies_of_neutrophil_chemotactic_factor_of_anaphylaxis_in_metabisulfite_sensitivity_ L2 - https://medlineplus.gov/anaphylaxis.html DB - PRIME DP - Unbound Medicine ER -