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Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis.
Oxid Med Cell Longev. 2017; 2017:9396425.OM

Abstract

Paraquat (PQ) is one of the most used herbicide worldwide. Its cytotoxicity is attributed to reactive radical generation. Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties. The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before. Therefore, we explored the protective potential of Res and/or MK against PQ hepatic toxicity in a mouse model. Mice were randomly assigned to five groups: group I served as the normal control and group II received a single dose of PQ (50 mg/kg, i.p.). Groups III, IV, and V received PQ plus oral Res (5 mg/kg/day), MK (10 mg/kg/day), and Res/MK combination, respectively. Res and/or MK reduced PQ-induced liver injury, evidenced by normalization of serum total protein, ALT, and AST. Res and/or MK significantly reversed PQ-induced oxidative stress markers glutathione and malondialdehyde. Res and/or MK significantly reduced PQ-induced inflammation reflected in TNF-α levels. Furthermore, Res and/or MK reversed PQ-induced apoptosis assessed by differential expression of p53, Bax, and Bcl-2. Histopathologic examination supported the biochemical findings. Although Res and MK displayed antioxidative, anti-inflammatory, and antiapoptotic activities, their combination was not always synergistic.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29201275

Citation

El-Boghdady, Noha A., et al. "Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis." Oxidative Medicine and Cellular Longevity, vol. 2017, 2017, p. 9396425.
El-Boghdady NA, Abdeltawab NF, Nooh MM. Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. Oxid Med Cell Longev. 2017;2017:9396425.
El-Boghdady, N. A., Abdeltawab, N. F., & Nooh, M. M. (2017). Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. Oxidative Medicine and Cellular Longevity, 2017, 9396425. https://doi.org/10.1155/2017/9396425
El-Boghdady NA, Abdeltawab NF, Nooh MM. Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. Oxid Med Cell Longev. 2017;2017:9396425. PubMed PMID: 29201275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. AU - El-Boghdady,Noha A, AU - Abdeltawab,Nourtan F, AU - Nooh,Mohammed M, Y1 - 2017/10/22/ PY - 2017/06/19/received PY - 2017/09/26/accepted PY - 2017/12/5/entrez PY - 2017/12/5/pubmed PY - 2018/7/10/medline SP - 9396425 EP - 9396425 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2017 N2 - Paraquat (PQ) is one of the most used herbicide worldwide. Its cytotoxicity is attributed to reactive radical generation. Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties. The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before. Therefore, we explored the protective potential of Res and/or MK against PQ hepatic toxicity in a mouse model. Mice were randomly assigned to five groups: group I served as the normal control and group II received a single dose of PQ (50 mg/kg, i.p.). Groups III, IV, and V received PQ plus oral Res (5 mg/kg/day), MK (10 mg/kg/day), and Res/MK combination, respectively. Res and/or MK reduced PQ-induced liver injury, evidenced by normalization of serum total protein, ALT, and AST. Res and/or MK significantly reversed PQ-induced oxidative stress markers glutathione and malondialdehyde. Res and/or MK significantly reduced PQ-induced inflammation reflected in TNF-α levels. Furthermore, Res and/or MK reversed PQ-induced apoptosis assessed by differential expression of p53, Bax, and Bcl-2. Histopathologic examination supported the biochemical findings. Although Res and MK displayed antioxidative, anti-inflammatory, and antiapoptotic activities, their combination was not always synergistic. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/29201275/Resveratrol_and_Montelukast_Alleviate_Paraquat_Induced_Hepatic_Injury_in_Mice:_Modulation_of_Oxidative_Stress_Inflammation_and_Apoptosis_ L2 - https://doi.org/10.1155/2017/9396425 DB - PRIME DP - Unbound Medicine ER -