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Gasotransmitter hydrogen sulfide signaling in neuronal health and disease.
Biochem Pharmacol. 2018 03; 149:101-109.BP

Abstract

Hydrogen sulfide is a gaseous signaling molecule or gasotransmitter which plays important roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike nitric oxide and carbon monoxide, the other major gasotransmitters, research on hydrogen sulfide is still in its infancy. One of the modes by which hydrogen sulfide signals is via a posttranslational modification termed sulfhydration/persulfidation, which occurs on reactive cysteine residues on target proteins, where the reactive SH group is converted to an SSH group. Sulfhydration is a substantially prevalent modification, which modulates the structure or function of proteins being modified. Thus, precise control of endogenous hydrogen sulfide production and metabolism is critical for maintenance of optimal cellular function, with excess generation and paucity, both contributing to pathology. Dysregulation of the reverse transsulfuration pathway which generates hydrogen sulfide occurs in several neurodegenerative diseases such as Parkinson's disease, Huntington's disease and Alzheimer's disease. Accordingly, treatment with donors of hydrogen sulfide or stimulation of the reverse transsulfuration have proved beneficial in several neurodegenerative states. In this review we focus on hydrogen sulfide mediated neuronal signaling processes that contribute to neuroprotection.

Authors+Show Affiliations

The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: bpaul8@jhmi.edu.The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: ssnyder@jhmi.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

29203369

Citation

Paul, Bindu D., and Solomon H. Snyder. "Gasotransmitter Hydrogen Sulfide Signaling in Neuronal Health and Disease." Biochemical Pharmacology, vol. 149, 2018, pp. 101-109.
Paul BD, Snyder SH. Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochem Pharmacol. 2018;149:101-109.
Paul, B. D., & Snyder, S. H. (2018). Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochemical Pharmacology, 149, 101-109. https://doi.org/10.1016/j.bcp.2017.11.019
Paul BD, Snyder SH. Gasotransmitter Hydrogen Sulfide Signaling in Neuronal Health and Disease. Biochem Pharmacol. 2018;149:101-109. PubMed PMID: 29203369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. AU - Paul,Bindu D, AU - Snyder,Solomon H, Y1 - 2017/12/01/ PY - 2017/09/28/received PY - 2017/11/29/accepted PY - 2017/12/6/pubmed PY - 2018/12/12/medline PY - 2017/12/6/entrez KW - Antioxidants KW - Gasotransmitter KW - Hydrogen sulfide KW - Neurodegeneration KW - Oxidative stress KW - Sulfhydration SP - 101 EP - 109 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 149 N2 - Hydrogen sulfide is a gaseous signaling molecule or gasotransmitter which plays important roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike nitric oxide and carbon monoxide, the other major gasotransmitters, research on hydrogen sulfide is still in its infancy. One of the modes by which hydrogen sulfide signals is via a posttranslational modification termed sulfhydration/persulfidation, which occurs on reactive cysteine residues on target proteins, where the reactive SH group is converted to an SSH group. Sulfhydration is a substantially prevalent modification, which modulates the structure or function of proteins being modified. Thus, precise control of endogenous hydrogen sulfide production and metabolism is critical for maintenance of optimal cellular function, with excess generation and paucity, both contributing to pathology. Dysregulation of the reverse transsulfuration pathway which generates hydrogen sulfide occurs in several neurodegenerative diseases such as Parkinson's disease, Huntington's disease and Alzheimer's disease. Accordingly, treatment with donors of hydrogen sulfide or stimulation of the reverse transsulfuration have proved beneficial in several neurodegenerative states. In this review we focus on hydrogen sulfide mediated neuronal signaling processes that contribute to neuroprotection. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/29203369/Gasotransmitter_hydrogen_sulfide_signaling_in_neuronal_health_and_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(17)30700-1 DB - PRIME DP - Unbound Medicine ER -