Citation
Sollmann, Nico, et al. "Sex Differences in White Matter Alterations Following Repetitive Subconcussive Head Impacts in Collegiate Ice Hockey Players." NeuroImage. Clinical, vol. 17, 2018, pp. 642-649.
Sollmann N, Echlin PS, Schultz V, et al. Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players. Neuroimage Clin. 2018;17:642-649.
Sollmann, N., Echlin, P. S., Schultz, V., Viher, P. V., Lyall, A. E., Tripodis, Y., Kaufmann, D., Hartl, E., Kinzel, P., Forwell, L. A., Johnson, A. M., Skopelja, E. N., Lepage, C., Bouix, S., Pasternak, O., Lin, A. P., Shenton, M. E., & Koerte, I. K. (2018). Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players. NeuroImage. Clinical, 17, 642-649. https://doi.org/10.1016/j.nicl.2017.11.020
Sollmann N, et al. Sex Differences in White Matter Alterations Following Repetitive Subconcussive Head Impacts in Collegiate Ice Hockey Players. Neuroimage Clin. 2018;17:642-649. PubMed PMID: 29204342.
TY - JOUR
T1 - Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players.
AU - Sollmann,Nico,
AU - Echlin,Paul S,
AU - Schultz,Vivian,
AU - Viher,Petra V,
AU - Lyall,Amanda E,
AU - Tripodis,Yorghos,
AU - Kaufmann,David,
AU - Hartl,Elisabeth,
AU - Kinzel,Philipp,
AU - Forwell,Lorie A,
AU - Johnson,Andrew M,
AU - Skopelja,Elaine N,
AU - Lepage,Christian,
AU - Bouix,Sylvain,
AU - Pasternak,Ofer,
AU - Lin,Alexander P,
AU - Shenton,Martha E,
AU - Koerte,Inga K,
Y1 - 2017/11/21/
PY - 2017/07/29/received
PY - 2017/11/08/revised
PY - 2017/11/18/accepted
PY - 2017/12/6/entrez
PY - 2017/12/6/pubmed
PY - 2018/8/1/medline
KW - AD, axial diffusivity
KW - CIS, Canadian Interuniversity Sports
KW - CR, corona radiata
KW - Diffusion tensor imaging
KW - EC, external capsule
KW - FA, fractional anisotropy
KW - HCEP, Hockey Concussion Education Project
KW - IC, internal capsule
KW - Ice hockey
KW - ImPACT, Immediate Post-Concussion Assessment and Cognitive Test
KW - LH, left hemisphere
KW - MD, mean diffusivity
KW - MRI, magnetic resonance imaging
KW - NCAA, National Collegiate Athletic Association
KW - RD, radial diffusivity
KW - RH, right hemisphere
KW - RSHI, repetitive subconcussive head impacts
KW - Repetitive subconcussive head impacts
KW - SD, standard deviation
KW - SLF, superior longitudinal fasciculus
KW - Sex difference
KW - TBI, traumatic brain injury
KW - TBSS, tract-based spatial statistics
KW - Traumatic brain injury
KW - WM, white matter
KW - White matter
KW - dMRI, diffusion magnetic resonance imaging
KW - rs, Spearman's rank correlation coefficient
SP - 642
EP - 649
JF - NeuroImage. Clinical
JO - Neuroimage Clin
VL - 17
N2 - Objective: Repetitive subconcussive head impacts (RSHI) may lead to structural, functional, and metabolic alterations of the brain. While differences between males and females have already been suggested following a concussion, whether there are sex differences following exposure to RSHI remains unknown. The aim of this study was to identify and to characterize sex differences following exposure to RSHI. Methods: Twenty-five collegiate ice hockey players (14 males and 11 females, 20.6 ± 2.0 years), all part of the Hockey Concussion Education Project (HCEP), underwent diffusion-weighted magnetic resonance imaging (dMRI) before and after the Canadian Interuniversity Sports (CIS) ice hockey season 2011-2012 and did not experience a concussion during the season. Whole-brain tract-based spatial statistics (TBSS) were used to compare pre- and postseason imaging in both sexes for fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Pre- and postseason neurocognitive performance were assessed by the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT). Results: Significant differences between the sexes were primarily located within the superior longitudinal fasciculus (SLF), the internal capsule (IC), and the corona radiata (CR) of the right hemisphere (RH). In significant voxel clusters (p < 0.05), decreases in FA (absolute difference pre- vs. postseason: 0.0268) and increases in MD (0.0002), AD (0.00008), and RD (0.00005) were observed in females whereas males showed no significant changes. There was no significant correlation between the change in diffusion scalar measures over the course of the season and neurocognitive performance as evidenced from postseason ImPACT scores. Conclusions: The results of this study suggest sex differences in structural alterations following exposure to RSHI. Future studies need to investigate further the underlying mechanisms and association with exposure and clinical outcomes.
SN - 2213-1582
UR - https://www.unboundmedicine.com/medline/citation/29204342/Sex_differences_in_white_matter_alterations_following_repetitive_subconcussive_head_impacts_in_collegiate_ice_hockey_players_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-1582(17)30300-5
DB - PRIME
DP - Unbound Medicine
ER -