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Case of epidermolysis bullosa acquisita with concomitant anti-laminin-332 antibodies.
J Dermatol. 2018 Apr; 45(4):472-474.JD

Abstract

Subepidermal autoimmune blistering disease including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, anti-laminin-γ1 pemphigoid, linear immunoglobulin A bullous disease and epidermolysis bullosa acquisita (EBA), are all characterized by direct immunofluorescence microscopy or immunoglobulin deposition on the basement membrane zone. Among them, EBA is a rare acquired subepidermal autoimmune blistering disease of the skin and mucous membranes reactive with type VII collagen, a major component of the epidermal basement membrane zone. Anti-laminin-332-type mucous membrane pemphigoid has pathogenic autoantibodies against laminin-332, which is a basement membrane heterotrimeric protein composed of α3, β3 and γ2 laminin chains. We describe a 73-year-old Japanese man presenting with multiple, annular, tense blisters on the lower legs and oral lesions. Despite the severe clinical manifestations, the disease was successfully controlled by combination therapy of oral prednisolone and mizoribine. This case was confirmed to have autoantibodies to both type VII collagen and laminin-332 α3 chain by indirect immunofluorescence of 1 mol NaCl-split normal human skin, various immunoblot analyses and enzyme-linked immunosorbent assays. This case was a rare case of EBA with concomitant anti-laminin-332 antibodies.

Authors+Show Affiliations

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.Toyokawa City Hospital, Toyokawa, Japan.Nagoya City East Medical Center, Nagoya, Japan.Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan.Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29205468

Citation

Nishida, Emi, et al. "Case of Epidermolysis Bullosa Acquisita With Concomitant Anti-laminin-332 Antibodies." The Journal of Dermatology, vol. 45, no. 4, 2018, pp. 472-474.
Nishida E, Nishio E, Murashima H, et al. Case of epidermolysis bullosa acquisita with concomitant anti-laminin-332 antibodies. J Dermatol. 2018;45(4):472-474.
Nishida, E., Nishio, E., Murashima, H., Ishii, N., Hashimoto, T., & Morita, A. (2018). Case of epidermolysis bullosa acquisita with concomitant anti-laminin-332 antibodies. The Journal of Dermatology, 45(4), 472-474. https://doi.org/10.1111/1346-8138.14169
Nishida E, et al. Case of Epidermolysis Bullosa Acquisita With Concomitant Anti-laminin-332 Antibodies. J Dermatol. 2018;45(4):472-474. PubMed PMID: 29205468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case of epidermolysis bullosa acquisita with concomitant anti-laminin-332 antibodies. AU - Nishida,Emi, AU - Nishio,Eiichi, AU - Murashima,Hiroko, AU - Ishii,Norito, AU - Hashimoto,Takashi, AU - Morita,Akimichi, Y1 - 2017/12/04/ PY - 2017/02/01/received PY - 2017/11/06/accepted PY - 2017/12/6/pubmed PY - 2018/9/25/medline PY - 2017/12/6/entrez KW - bullous pemphigoid KW - epidermolysis bullosa acquisita KW - laminin-332 KW - mucous membrane pemphigoid KW - α3 laminin chain SP - 472 EP - 474 JF - The Journal of dermatology JO - J Dermatol VL - 45 IS - 4 N2 - Subepidermal autoimmune blistering disease including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, anti-laminin-γ1 pemphigoid, linear immunoglobulin A bullous disease and epidermolysis bullosa acquisita (EBA), are all characterized by direct immunofluorescence microscopy or immunoglobulin deposition on the basement membrane zone. Among them, EBA is a rare acquired subepidermal autoimmune blistering disease of the skin and mucous membranes reactive with type VII collagen, a major component of the epidermal basement membrane zone. Anti-laminin-332-type mucous membrane pemphigoid has pathogenic autoantibodies against laminin-332, which is a basement membrane heterotrimeric protein composed of α3, β3 and γ2 laminin chains. We describe a 73-year-old Japanese man presenting with multiple, annular, tense blisters on the lower legs and oral lesions. Despite the severe clinical manifestations, the disease was successfully controlled by combination therapy of oral prednisolone and mizoribine. This case was confirmed to have autoantibodies to both type VII collagen and laminin-332 α3 chain by indirect immunofluorescence of 1 mol NaCl-split normal human skin, various immunoblot analyses and enzyme-linked immunosorbent assays. This case was a rare case of EBA with concomitant anti-laminin-332 antibodies. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/29205468/Case_of_epidermolysis_bullosa_acquisita_with_concomitant_anti_laminin_332_antibodies_ L2 - https://doi.org/10.1111/1346-8138.14169 DB - PRIME DP - Unbound Medicine ER -