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The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease.
Int J Mol Sci. 2017 Dec 05; 18(12)IJ

Abstract

Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR), FK506 binding protein (FKBP) 51 is the most intensely investigated across different disciplines. This review provides an update on the role of the different co-chaperones of Hsp70 and Hsp90 in the regulation of GR function. The development leading to the focus on FKBP51 is outlined. Further, a survey of the vast literature on the mechanism and function of FKBP51 is provided. This includes its structure and biochemical function, its regulation on different levels-transcription, post-transcription, and post-translation-and its function in signaling pathways. The evidence portraying FKBP51 as a scaffolding protein organizing protein complexes rather than a chaperone contributing to the folding of individual proteins is collated. Finally, FKBP51's involvement in physiology and disease is outlined, and the promising efforts in developing drugs targeting FKBP51 are discussed.

Authors+Show Affiliations

Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA. Gabriel.R.Fries@uth.tmc.edu.Department of Translational Science in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ncgassen@psych.mpg.de.Department of Translational Science in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. theorein@psych.mpg.de.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29206196

Citation

Fries, Gabriel R., et al. "The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease." International Journal of Molecular Sciences, vol. 18, no. 12, 2017.
Fries GR, Gassen NC, Rein T. The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease. Int J Mol Sci. 2017;18(12).
Fries, G. R., Gassen, N. C., & Rein, T. (2017). The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease. International Journal of Molecular Sciences, 18(12). https://doi.org/10.3390/ijms18122614
Fries GR, Gassen NC, Rein T. The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease. Int J Mol Sci. 2017 Dec 5;18(12) PubMed PMID: 29206196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease. AU - Fries,Gabriel R, AU - Gassen,Nils C, AU - Rein,Theo, Y1 - 2017/12/05/ PY - 2017/10/30/received PY - 2017/11/21/revised PY - 2017/11/29/accepted PY - 2017/12/6/entrez PY - 2017/12/6/pubmed PY - 2018/8/28/medline KW - FKBP5 KW - FKBP51 KW - chaperone KW - drug KW - glucocorticoid receptor KW - signaling pathway JF - International journal of molecular sciences JO - Int J Mol Sci VL - 18 IS - 12 N2 - Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR), FK506 binding protein (FKBP) 51 is the most intensely investigated across different disciplines. This review provides an update on the role of the different co-chaperones of Hsp70 and Hsp90 in the regulation of GR function. The development leading to the focus on FKBP51 is outlined. Further, a survey of the vast literature on the mechanism and function of FKBP51 is provided. This includes its structure and biochemical function, its regulation on different levels-transcription, post-transcription, and post-translation-and its function in signaling pathways. The evidence portraying FKBP51 as a scaffolding protein organizing protein complexes rather than a chaperone contributing to the folding of individual proteins is collated. Finally, FKBP51's involvement in physiology and disease is outlined, and the promising efforts in developing drugs targeting FKBP51 are discussed. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/29206196/The_FKBP51_Glucocorticoid_Receptor_Co_Chaperone:_Regulation_Function_and_Implications_in_Health_and_Disease_ L2 - https://www.mdpi.com/resolver?pii=ijms18122614 DB - PRIME DP - Unbound Medicine ER -