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Infants born to mothers with antibodies against Borrelia burgdorferi at delivery.

Abstract

A serological survey over a 1-year period of 1416 mothers at delivery and their 1434 offspring for the presence of anti-Borrelia burgdorferi antibodies revealed a prevalence of 0.85%. Clinically active Lyme disease during pregnancy was found in 1 of these 12 women with elevated titres and the child was born with a ventricular septal defect. Of six affected children, two had hyperbilirubinaemia, one muscular hypotonia, one was underweight for gestational age, one was macrocephalic, and one had supraventricular extrasystoles. Anomalous findings could not be attributed to B. burgdorferi due to a lack of serological evidence of intrauterine infection. Our data do not imply the need for serological screening in pregnancy, however, the importance of recognition and treatment of Lyme disease in pregnancy is emphasized.

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  • Authors+Show Affiliations

    ,

    Abteilungen für Infektionskrankheiten und Immunologie der Universität, Zürich, Switzerland.

    , , ,

    Source

    European journal of pediatrics 148:5 1989 Feb pg 426-7

    MeSH

    Adult
    Antibodies, Bacterial
    Borrelia
    Child Development
    Female
    Humans
    Immunoglobulin G
    Infant, Newborn
    Infant, Newborn, Diseases
    Labor, Obstetric
    Lyme Disease
    Pregnancy
    Pregnancy Complications, Infectious
    Pregnancy Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    2920747

    Citation

    TY - JOUR T1 - Infants born to mothers with antibodies against Borrelia burgdorferi at delivery. AU - Nadal,D, AU - Hunziker,U A, AU - Bucher,H U, AU - Hitzig,W H, AU - Duc,G, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 426 EP - 7 JF - European journal of pediatrics JO - Eur. J. Pediatr. VL - 148 IS - 5 N2 - A serological survey over a 1-year period of 1416 mothers at delivery and their 1434 offspring for the presence of anti-Borrelia burgdorferi antibodies revealed a prevalence of 0.85%. Clinically active Lyme disease during pregnancy was found in 1 of these 12 women with elevated titres and the child was born with a ventricular septal defect. Of six affected children, two had hyperbilirubinaemia, one muscular hypotonia, one was underweight for gestational age, one was macrocephalic, and one had supraventricular extrasystoles. Anomalous findings could not be attributed to B. burgdorferi due to a lack of serological evidence of intrauterine infection. Our data do not imply the need for serological screening in pregnancy, however, the importance of recognition and treatment of Lyme disease in pregnancy is emphasized. SN - 0340-6199 UR - https://www.unboundmedicine.com/medline/citation/2920747/abstract/Infants_born_to_mothers_with_antibodies_against_Borrelia_burgdorferi_at_delivery_ L2 - http://www.nlm.nih.gov/medlineplus/childbirth.html ER -