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Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F1 progeny rats.
Reprod Toxicol. 2018 01; 75:73-85.RT

Abstract

The present study was aimed to determine the effects of lactational exposure of PCBs (Aroclor 1254) on Leydig cellular steroidogenesis in F1 progeny rats. Lactating dams were orally treated by gavage with different doses of PCBs (1, 2 and 5mg/kg b.wt./day). Male progenies were sacrificed on PND60. Our results demonstrated that exposure to PCBs decreased the body weight, testis weight and anogenital distance (AGD) index in the F1 progeny rats. Importantly, PCBs exposure reduced the serum levels of LH, testosterone and estradiol. Interestingly, PCBs caused a decrease in the Leydig cell population along with decreased activities of steroidogenic enzymes 3β- and 17β-HSD. Additionally, we observed a significant decrease in LHR, SR-B1, StAR protein, Cyp11a1, 3β-HSD, Cyp17a1, 17β-HSD, 5α-reductase, Cyp19a1 and AR gene expression in the Leydig cells of progeny rats. In conclusion, our study demonstrates that lactational exposure of PCBs alters Leydig cellular steroidogenesis in the F1 progeny rats.

Authors+Show Affiliations

Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, Tamil Nadu, India.Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, Tamil Nadu, India.Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, Tamil Nadu, India.Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, Tamil Nadu, India.Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, Tamil Nadu, India. Electronic address: j_arunakaran@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29208485

Citation

Thangavelu, Sathish Kumar, et al. "Lactational Exposure of Polychlorinated Biphenyls Impair Leydig Cellular Steroidogenesis in F1 Progeny Rats." Reproductive Toxicology (Elmsford, N.Y.), vol. 75, 2018, pp. 73-85.
Thangavelu SK, Elaiyapillai SP, Ramachandran I, et al. Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F1 progeny rats. Reprod Toxicol. 2018;75:73-85.
Thangavelu, S. K., Elaiyapillai, S. P., Ramachandran, I., Bhaskaran, R. S., & Jagadeesan, A. (2018). Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F1 progeny rats. Reproductive Toxicology (Elmsford, N.Y.), 75, 73-85. https://doi.org/10.1016/j.reprotox.2017.11.009
Thangavelu SK, et al. Lactational Exposure of Polychlorinated Biphenyls Impair Leydig Cellular Steroidogenesis in F1 Progeny Rats. Reprod Toxicol. 2018;75:73-85. PubMed PMID: 29208485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F1 progeny rats. AU - Thangavelu,Sathish Kumar, AU - Elaiyapillai,Sugantha Priya, AU - Ramachandran,Ilangovan, AU - Bhaskaran,Ravi Sankar, AU - Jagadeesan,Arunakaran, Y1 - 2017/12/05/ PY - 2017/07/26/received PY - 2017/10/30/revised PY - 2017/11/28/accepted PY - 2017/12/7/pubmed PY - 2018/11/1/medline PY - 2017/12/7/entrez KW - Aroclor 1254 KW - Leydig cells KW - PCBs KW - Polychlorinated biphenyls KW - Steroidogenesis KW - Testosterone SP - 73 EP - 85 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod Toxicol VL - 75 N2 - The present study was aimed to determine the effects of lactational exposure of PCBs (Aroclor 1254) on Leydig cellular steroidogenesis in F1 progeny rats. Lactating dams were orally treated by gavage with different doses of PCBs (1, 2 and 5mg/kg b.wt./day). Male progenies were sacrificed on PND60. Our results demonstrated that exposure to PCBs decreased the body weight, testis weight and anogenital distance (AGD) index in the F1 progeny rats. Importantly, PCBs exposure reduced the serum levels of LH, testosterone and estradiol. Interestingly, PCBs caused a decrease in the Leydig cell population along with decreased activities of steroidogenic enzymes 3β- and 17β-HSD. Additionally, we observed a significant decrease in LHR, SR-B1, StAR protein, Cyp11a1, 3β-HSD, Cyp17a1, 17β-HSD, 5α-reductase, Cyp19a1 and AR gene expression in the Leydig cells of progeny rats. In conclusion, our study demonstrates that lactational exposure of PCBs alters Leydig cellular steroidogenesis in the F1 progeny rats. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/29208485/Lactational_exposure_of_polychlorinated_biphenyls_impair_Leydig_cellular_steroidogenesis_in_F1_progeny_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(17)30559-2 DB - PRIME DP - Unbound Medicine ER -