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Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population.
Eur J Nutr. 2019 Feb; 58(1):261-270.EJ

Abstract

PURPOSE

We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency.

METHODS

Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine.

RESULTS

The study groups did not differ at baseline and were characterized by [median (range)] serum cobalamin [128 (68-191) pmol/L], holotranscobalamin [16 (6-41) pmol/L], methylmalonic acid [0.8 (0.3-1.7) µmol/L], homocysteine [17.9 (8.5-100.9) µmol/L], and a combined indicator of B12 status 4cB12 of - 1.65 (- 0.64 to - 4.07). The group supplemented with cyano-B12 showed a higher increase in total serum cobalamin than the group treated with hydroxo-B12, while other biomarkers changed comparably in the two groups. After 8 weeks of treatment, the biomarker values of the supplemented groups (pooled) differed significantly from the placebo group. Yet, the vitamin B12 status was still poor [cobalamin: 168 (87-302) pmol/L; holotranscobalamin: 19 (8-45) pmol/L; methylmalonic acid: 0.7 (0.2-1.7) µmol/L; homocysteine: 17.2 (2.6-96.8) µmol/L; 4cB12 = - 1.34 (- 0.33 to - 3.3)].

CONCLUSION

8-week supplementation with 3-µg cyano-B12 elevated serum cobalamin more than 3 µg hydroxo-B12, but all other biomarkers changed similarly in both groups. Supplementation with 3 µg vitamin B12 did not reverse the low status in individuals with nutritional vitamin B12 deficiency.

CLINICAL TRIAL REGISTRY OF INDIA

REF/2017/02/013343.

Links

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Authors+Show Affiliations

Greibe E
Department of Clinical Biochemistry and Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. greibe@clin.au.dk.
Mahalle N
Department of Pathology, Deenanath Mangeshkar Hospital and Research Center, Pune, India.
Bhide V
Department of Pathology, Deenanath Mangeshkar Hospital and Research Center, Pune, India.
Fedosov S
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Heegaard CW
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Naik S
Department of Pathology, Deenanath Mangeshkar Hospital and Research Center, Pune, India. sadu_naik@rediffmail.com.
Nexo E
Department of Clinical Biochemistry and Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.

MeSH

Administration, OralAdultBiomarkersCohort StudiesDietary SupplementsFemaleHumansHydroxocobalaminIndiaLongitudinal StudiesMaleMiddle AgedTreatment OutcomeVitamin B 12Vitamin B 12 DeficiencyVitamin B ComplexYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29209773

Citation

Greibe, Eva, et al. "Effect of 8-week Oral Supplementation With 3-µg cyano-B12 or hydroxo-B12 in a Vitamin B12-deficient Population." European Journal of Nutrition, vol. 58, no. 1, 2019, pp. 261-270.
Greibe E, Mahalle N, Bhide V, et al. Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population. Eur J Nutr. 2019;58(1):261-270.
Greibe, E., Mahalle, N., Bhide, V., Fedosov, S., Heegaard, C. W., Naik, S., & Nexo, E. (2019). Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population. European Journal of Nutrition, 58(1), 261-270. https://doi.org/10.1007/s00394-017-1590-0
Greibe E, et al. Effect of 8-week Oral Supplementation With 3-µg cyano-B12 or hydroxo-B12 in a Vitamin B12-deficient Population. Eur J Nutr. 2019;58(1):261-270. PubMed PMID: 29209773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population. AU - Greibe,Eva, AU - Mahalle,Namita, AU - Bhide,Vijayshri, AU - Fedosov,Sergey, AU - Heegaard,Christian W, AU - Naik,Sadanand, AU - Nexo,Ebba, Y1 - 2017/12/05/ PY - 2017/07/03/received PY - 2017/11/29/accepted PY - 2017/12/7/pubmed PY - 2019/8/6/medline PY - 2017/12/7/entrez KW - B12 deficiency KW - B12 supplementation KW - Cobalamin KW - Cyano-B12 KW - Hydroxo-B12 KW - Vitamin B12 SP - 261 EP - 270 JF - European journal of nutrition JO - Eur J Nutr VL - 58 IS - 1 N2 - PURPOSE: We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. METHODS: Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine. RESULTS: The study groups did not differ at baseline and were characterized by [median (range)] serum cobalamin [128 (68-191) pmol/L], holotranscobalamin [16 (6-41) pmol/L], methylmalonic acid [0.8 (0.3-1.7) µmol/L], homocysteine [17.9 (8.5-100.9) µmol/L], and a combined indicator of B12 status 4cB12 of - 1.65 (- 0.64 to - 4.07). The group supplemented with cyano-B12 showed a higher increase in total serum cobalamin than the group treated with hydroxo-B12, while other biomarkers changed comparably in the two groups. After 8 weeks of treatment, the biomarker values of the supplemented groups (pooled) differed significantly from the placebo group. Yet, the vitamin B12 status was still poor [cobalamin: 168 (87-302) pmol/L; holotranscobalamin: 19 (8-45) pmol/L; methylmalonic acid: 0.7 (0.2-1.7) µmol/L; homocysteine: 17.2 (2.6-96.8) µmol/L; 4cB12 = - 1.34 (- 0.33 to - 3.3)]. CONCLUSION: 8-week supplementation with 3-µg cyano-B12 elevated serum cobalamin more than 3 µg hydroxo-B12, but all other biomarkers changed similarly in both groups. Supplementation with 3 µg vitamin B12 did not reverse the low status in individuals with nutritional vitamin B12 deficiency. CLINICAL TRIAL REGISTRY OF INDIA: REF/2017/02/013343. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/29209773/Effect_of_8_week_oral_supplementation_with_3_µg_cyano_B12_or_hydroxo_B12_in_a_vitamin_B12_deficient_population_ DB - PRIME DP - Unbound Medicine ER -