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Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides.
Oxid Med Cell Longev. 2017; 2017:8320804.OM

Abstract

Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.

Authors+Show Affiliations

Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.Laboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Cidade Universitária, 79070-900 Campo Grande, MS, Brazil.Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.Laboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Cidade Universitária, 79070-900 Campo Grande, MS, Brazil.Agricultural College of Bragança, Polytechnic Institute of Bragança, Campus Santa Apolónia, 5301-855 Bragança, Portugal. Molecular and Environmental Biology Centre (CBMA), Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal.Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29213354

Citation

Dos Santos, Cintia Miranda, et al. "Chemical Composition and Pharmacological Effects of Geopropolis Produced By Melipona Quadrifasciata Anthidioides." Oxidative Medicine and Cellular Longevity, vol. 2017, 2017, p. 8320804.
Dos Santos CM, Campos JF, Dos Santos HF, et al. Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides. Oxid Med Cell Longev. 2017;2017:8320804.
Dos Santos, C. M., Campos, J. F., Dos Santos, H. F., Balestieri, J. B. P., Silva, D. B., de Picoli Souza, K., Carollo, C. A., Estevinho, L. M., & Dos Santos, E. L. (2017). Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity, 2017, 8320804. https://doi.org/10.1155/2017/8320804
Dos Santos CM, et al. Chemical Composition and Pharmacological Effects of Geopropolis Produced By Melipona Quadrifasciata Anthidioides. Oxid Med Cell Longev. 2017;2017:8320804. PubMed PMID: 29213354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides. AU - Dos Santos,Cintia Miranda, AU - Campos,Jaqueline Ferreira, AU - Dos Santos,Helder Freitas, AU - Balestieri,José Benedito Perrella, AU - Silva,Denise Brentan, AU - de Picoli Souza,Kely, AU - Carollo,Carlos Alexandre, AU - Estevinho,Leticia M, AU - Dos Santos,Edson Lucas, Y1 - 2017/10/26/ PY - 2017/07/31/received PY - 2017/09/24/accepted PY - 2017/12/8/entrez PY - 2017/12/8/pubmed PY - 2018/7/18/medline SP - 8320804 EP - 8320804 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2017 N2 - Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/29213354/Chemical_Composition_and_Pharmacological_Effects_of_Geopropolis_Produced_by_Melipona_quadrifasciata_anthidioides_ L2 - https://dx.doi.org/10.1155/2017/8320804 DB - PRIME DP - Unbound Medicine ER -