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An investigation of the independent risk factors that differentiate gout from pseudogout in patients with crystal-induced acute arthritis: a cross-sectional study.
Rheumatol Int. 2018 Jan; 38(1):89-95.RI

Abstract

OBJECTIVES

To identify independent risk factors that differentiate gout from pseudogout in patients that present with crystal-induced acute arthritis.

METHODS

This cross-sectional study was conducted at Siriraj Hospital (Bangkok, Thailand) during the 25 May 2014-28 November 2014 study period. Patients who presented with crystal-induced acute arthritis were eligible for inclusion. Diagnosis of gout or pseudogout was made by microscopic visualization and analysis of crystals in synovial fluid. Patients with other causes of acute arthritis were excluded. Patients diagnosed with gout were compared with patients diagnosed with pseudogout and factors with a p value less than 0.05 were included in logistic regression analysis.

RESULTS

A total of 103 patients were included. Gout and pseudogout were established in 59 (56.7%) and 44 (42.3%) patients, respectively. Gout patients were younger than pseudogout patients (66.9 ± 14.5 vs. 78.9 ± 12.0 years; p = 0.0001); had higher BMI (22.9 ± 2.5 vs. 21.0 ± 2.5 kg/m2; p = 0.001); had history of recurrent arthritis (91.5 vs. 9.1%; p = 0.001); had higher prevalence of below-knee arthritis (66.1 vs. 31.8%; p = 0.001); had less periarticular soft tissue swelling (57.6 vs. 81.8%; p = 0.01); and had hyperuricemia (8.0 ± 2.5 vs. 5.6 ± 2.7; p = 0.001). In adjusted multivariate analysis, hyperuricemia during acute arthritis/gouty attack characterized gout (OR 2.08, 95% CI 1.2-3.6), while monoarticular attack (OR 4.12, 95% CI 1.3-13.0) and periarticular soft tissue swelling (OR 4.03, 95% CI 1.1-14.9) were indications for pseudogout.

CONCLUSIONS

The independent risk factors were found to differentiate gout from pseudogout: Gout: hyperuricemia during gouty attack; Pseudogout: monoarticular attack and periarticular soft tissue swelling.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Muangchan C
Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. chayawee.mua@mahidol.ac.th.
Bhurihirun T
Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

MeSH

Age FactorsAgedAged, 80 and overArthritisChondrocalcinosisCross-Sectional StudiesFemaleGoutHumansHyperuricemiaMaleMiddle AgedRisk FactorsThailand

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29214345

Citation

Muangchan, Chayawee, and Thitirat Bhurihirun. "An Investigation of the Independent Risk Factors That Differentiate Gout From Pseudogout in Patients With Crystal-induced Acute Arthritis: a Cross-sectional Study." Rheumatology International, vol. 38, no. 1, 2018, pp. 89-95.
Muangchan C, Bhurihirun T. An investigation of the independent risk factors that differentiate gout from pseudogout in patients with crystal-induced acute arthritis: a cross-sectional study. Rheumatol Int. 2018;38(1):89-95.
Muangchan, C., & Bhurihirun, T. (2018). An investigation of the independent risk factors that differentiate gout from pseudogout in patients with crystal-induced acute arthritis: a cross-sectional study. Rheumatology International, 38(1), 89-95. https://doi.org/10.1007/s00296-017-3891-2
Muangchan C, Bhurihirun T. An Investigation of the Independent Risk Factors That Differentiate Gout From Pseudogout in Patients With Crystal-induced Acute Arthritis: a Cross-sectional Study. Rheumatol Int. 2018;38(1):89-95. PubMed PMID: 29214345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An investigation of the independent risk factors that differentiate gout from pseudogout in patients with crystal-induced acute arthritis: a cross-sectional study. AU - Muangchan,Chayawee, AU - Bhurihirun,Thitirat, Y1 - 2017/12/06/ PY - 2017/10/04/received PY - 2017/11/21/accepted PY - 2017/12/8/pubmed PY - 2018/9/27/medline PY - 2017/12/8/entrez KW - Acute gout KW - Acute pseudogout KW - Calcium pyrophosphate dihydrate crystals KW - Crystal-induced acute arthritis KW - Monosodium urate crystals SP - 89 EP - 95 JF - Rheumatology international JO - Rheumatol Int VL - 38 IS - 1 N2 - OBJECTIVES: To identify independent risk factors that differentiate gout from pseudogout in patients that present with crystal-induced acute arthritis. METHODS: This cross-sectional study was conducted at Siriraj Hospital (Bangkok, Thailand) during the 25 May 2014-28 November 2014 study period. Patients who presented with crystal-induced acute arthritis were eligible for inclusion. Diagnosis of gout or pseudogout was made by microscopic visualization and analysis of crystals in synovial fluid. Patients with other causes of acute arthritis were excluded. Patients diagnosed with gout were compared with patients diagnosed with pseudogout and factors with a p value less than 0.05 were included in logistic regression analysis. RESULTS: A total of 103 patients were included. Gout and pseudogout were established in 59 (56.7%) and 44 (42.3%) patients, respectively. Gout patients were younger than pseudogout patients (66.9 ± 14.5 vs. 78.9 ± 12.0 years; p = 0.0001); had higher BMI (22.9 ± 2.5 vs. 21.0 ± 2.5 kg/m2; p = 0.001); had history of recurrent arthritis (91.5 vs. 9.1%; p = 0.001); had higher prevalence of below-knee arthritis (66.1 vs. 31.8%; p = 0.001); had less periarticular soft tissue swelling (57.6 vs. 81.8%; p = 0.01); and had hyperuricemia (8.0 ± 2.5 vs. 5.6 ± 2.7; p = 0.001). In adjusted multivariate analysis, hyperuricemia during acute arthritis/gouty attack characterized gout (OR 2.08, 95% CI 1.2-3.6), while monoarticular attack (OR 4.12, 95% CI 1.3-13.0) and periarticular soft tissue swelling (OR 4.03, 95% CI 1.1-14.9) were indications for pseudogout. CONCLUSIONS: The independent risk factors were found to differentiate gout from pseudogout: Gout: hyperuricemia during gouty attack; Pseudogout: monoarticular attack and periarticular soft tissue swelling. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/29214345/An_investigation_of_the_independent_risk_factors_that_differentiate_gout_from_pseudogout_in_patients_with_crystal_induced_acute_arthritis:_a_cross_sectional_study_ DB - PRIME DP - Unbound Medicine ER -