Tags

Type your tag names separated by a space and hit enter

β1-Adrenoceptor in the Central Amygdala Is Required for Unconditioned Stimulus-Induced Drug Memory Reconsolidation.
Int J Neuropsychopharmacol. 2018 03 01; 21(3):267-280.IJ

Abstract

Background

Drug memories become labile and reconsolidated after retrieval by presentation of environmental cues (conditioned stimulus) or drugs (unconditioned stimulus). Whether conditioned stimulus and unconditioned stimulus retrieval trigger different memory reconsolidation processes is not clear.

Methods

Protein synthesis inhibitor or β-adrenergic receptor (β-AR) antagonist was systemically administrated or intra-central amygdala infused immediately after cocaine reexposure in cocaine-conditioned place preference or self-administration mice models. β-ARs were selectively knocked out in the central amygdala to further confirm the role of β-adrenergic receptor in cocaine reexposure-induced memory reconsolidation of cocaine-conditioned place preference.

Results

Cocaine reexposure triggered de novo protein synthesis dependent memory reconsolidation of cocaine-conditioned place preference. Cocaine-priming-induced reinstatement was also impaired with post cocaine retrieval manipulation, in contrast to the relapse behavior with post context retrieval manipulation. Cocaine retrieval, but not context retrieval, induced central amygdala activation. Protein synthesis inhibitor or β1-adrenergic receptor antagonist infused in the central amygdala after cocaine retrieval, but not context retrieval, inhibited memory reconsolidation and reinstatement. β1-adrenergic receptor knockout in the central amygdala suppressed cocaine retrieval-triggered memory reconsolidation and reinstatement of cocaine conditioned place preference. β1-adrenergic receptor antagonism after cocaine retrieval also impaired reconsolidation and reinstatement of cocaine self-administration.

Conclusions

Cocaine reward memory triggered by unconditioned stimulus retrieval is distinct from conditioned stimulus retrieval. Unconditioned stimulus retrieval induced reconsolidation of cocaine reward memory depends on β1-adrenergic signaling in the central amygdala. Post unconditioned stimulus retrieval manipulation can prevent drug memory reconsolidation and relapse to cocaine, thus providing a potential strategy for the prevention of substance addiction.

Significance Statement

It is well known that drug memories become labile and reconsolidated upon retrieval by the presentation of conditioned stimulus (CS) or unconditioned stimulus (US). Whether CS and US retrieval trigger different memory reconsolidation processes is unknown. In this study, we found that US retrieval, but not CS retrieval, triggered memory reconsolidation of cocaine-conditioned place preference dependent on β1-AR and de novo protein synthesis in the central amygdala. Furthermore, cocaine priming-induced reinstatement was impaired with post US retrieval manipulation in contrast to the relapse behavior with post CS retrieval manipulation. In cocaine self-administration, β1-AR antagonism after US retrieval also impaired reconsolidation and reinstatement. Our study indicates that reconsolidation of cocaine reward memory triggered by US retrieval is distinct from CS retrieval. US retrieval induced reconsolidation of cocaine reward memory depends on β1-adrenergic signaling in the central amygdala.

Authors+Show Affiliations

The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.The State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and the Institutes of Brain Science, and the Collaborative Innovation Center for Brain Science, and Pharmacology Research Center, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29216351

Citation

Zhu, Huiwen, et al. "Β1-Adrenoceptor in the Central Amygdala Is Required for Unconditioned Stimulus-Induced Drug Memory Reconsolidation." The International Journal of Neuropsychopharmacology, vol. 21, no. 3, 2018, pp. 267-280.
Zhu H, Zhou Y, Liu Z, et al. Β1-Adrenoceptor in the Central Amygdala Is Required for Unconditioned Stimulus-Induced Drug Memory Reconsolidation. Int J Neuropsychopharmacol. 2018;21(3):267-280.
Zhu, H., Zhou, Y., Liu, Z., Chen, X., Li, Y., Liu, X., & Ma, L. (2018). Β1-Adrenoceptor in the Central Amygdala Is Required for Unconditioned Stimulus-Induced Drug Memory Reconsolidation. The International Journal of Neuropsychopharmacology, 21(3), 267-280. https://doi.org/10.1093/ijnp/pyx104
Zhu H, et al. Β1-Adrenoceptor in the Central Amygdala Is Required for Unconditioned Stimulus-Induced Drug Memory Reconsolidation. Int J Neuropsychopharmacol. 2018 03 1;21(3):267-280. PubMed PMID: 29216351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - β1-Adrenoceptor in the Central Amygdala Is Required for Unconditioned Stimulus-Induced Drug Memory Reconsolidation. AU - Zhu,Huiwen, AU - Zhou,Yiming, AU - Liu,Zhiyuan, AU - Chen,Xi, AU - Li,Yanqing, AU - Liu,Xing, AU - Ma,Lan, PY - 2017/09/07/received PY - 2017/12/01/accepted PY - 2017/12/8/pubmed PY - 2019/4/19/medline PY - 2017/12/8/entrez SP - 267 EP - 280 JF - The international journal of neuropsychopharmacology JO - Int J Neuropsychopharmacol VL - 21 IS - 3 N2 - Background: Drug memories become labile and reconsolidated after retrieval by presentation of environmental cues (conditioned stimulus) or drugs (unconditioned stimulus). Whether conditioned stimulus and unconditioned stimulus retrieval trigger different memory reconsolidation processes is not clear. Methods: Protein synthesis inhibitor or β-adrenergic receptor (β-AR) antagonist was systemically administrated or intra-central amygdala infused immediately after cocaine reexposure in cocaine-conditioned place preference or self-administration mice models. β-ARs were selectively knocked out in the central amygdala to further confirm the role of β-adrenergic receptor in cocaine reexposure-induced memory reconsolidation of cocaine-conditioned place preference. Results: Cocaine reexposure triggered de novo protein synthesis dependent memory reconsolidation of cocaine-conditioned place preference. Cocaine-priming-induced reinstatement was also impaired with post cocaine retrieval manipulation, in contrast to the relapse behavior with post context retrieval manipulation. Cocaine retrieval, but not context retrieval, induced central amygdala activation. Protein synthesis inhibitor or β1-adrenergic receptor antagonist infused in the central amygdala after cocaine retrieval, but not context retrieval, inhibited memory reconsolidation and reinstatement. β1-adrenergic receptor knockout in the central amygdala suppressed cocaine retrieval-triggered memory reconsolidation and reinstatement of cocaine conditioned place preference. β1-adrenergic receptor antagonism after cocaine retrieval also impaired reconsolidation and reinstatement of cocaine self-administration. Conclusions: Cocaine reward memory triggered by unconditioned stimulus retrieval is distinct from conditioned stimulus retrieval. Unconditioned stimulus retrieval induced reconsolidation of cocaine reward memory depends on β1-adrenergic signaling in the central amygdala. Post unconditioned stimulus retrieval manipulation can prevent drug memory reconsolidation and relapse to cocaine, thus providing a potential strategy for the prevention of substance addiction. Significance Statement: It is well known that drug memories become labile and reconsolidated upon retrieval by the presentation of conditioned stimulus (CS) or unconditioned stimulus (US). Whether CS and US retrieval trigger different memory reconsolidation processes is unknown. In this study, we found that US retrieval, but not CS retrieval, triggered memory reconsolidation of cocaine-conditioned place preference dependent on β1-AR and de novo protein synthesis in the central amygdala. Furthermore, cocaine priming-induced reinstatement was impaired with post US retrieval manipulation in contrast to the relapse behavior with post CS retrieval manipulation. In cocaine self-administration, β1-AR antagonism after US retrieval also impaired reconsolidation and reinstatement. Our study indicates that reconsolidation of cocaine reward memory triggered by US retrieval is distinct from CS retrieval. US retrieval induced reconsolidation of cocaine reward memory depends on β1-adrenergic signaling in the central amygdala. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/29216351/β1_Adrenoceptor_in_the_Central_Amygdala_Is_Required_for_Unconditioned_Stimulus_Induced_Drug_Memory_Reconsolidation_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1093/ijnp/pyx104 DB - PRIME DP - Unbound Medicine ER -