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[Standard decoction of Leonuri Herba].
Zhongguo Zhong Yao Za Zhi. 2017 Sep; 42(18):3523-3529.ZZ

Abstract

To build an evaluation standard for quality of Leonuri Herba standard decoction. 13 batches of Leonuri Herba standard decoction with different quality were prepared. The contents of leonurine hydrochloride and stachydrine hydrochloride were determined; then the transfer rate and the extract rate were calculated and pH value was measured; and HPLC fingerprint method was established for analysis. The results of 13 batches of samples revealed that the transfer rate of leonurine hydrochloride and stachydrine hydrochloride was 30.0%-53.4% and 67.0%-82.6%, respectively; the extract rate was 12.1%-18.3% and the pH value was 5.87-6.22. Moreover, 12 common chromatographic peaks were determined based on fingerprint by using Similarity Evaluation System for Chromatographic fingerprint of Traditional Chinese Medicine (2012A). The similarity of 13 batches of samples was analyzed and compared, and the results showed that the similarity was higher than 0.9. In this study, the preparation method for Leonuri Herba decoction was standard, with high similarity in fingerprint, showing high precision, stability and repeatability in fingerprint analysis. Thus, this study can provide a reference for the quality control of Leonuri Herba dispensing granules.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

MeSH

Chromatography, High Pressure LiquidDrugs, Chinese HerbalLeonurusQuality Control

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29218937

Citation

Deng, Zhe, et al. "[Standard Decoction of Leonuri Herba]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 42, no. 18, 2017, pp. 3523-3529.

Deng Z, Zhang F, Zhang J, et al. [Standard decoction of Leonuri Herba]. Zhongguo Zhong Yao Za Zhi. 2017;42(18):3523-3529.

Deng, Z., Zhang, F., Zhang, J., Zhang, Q., Jiao, M. J., Zhang, G. Y., Cheng, J. T., Liu, A., & Wang, Y. S. (2017). [Standard decoction of Leonuri Herba]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(18), 3523-3529. https://doi.org/10.19540/j.cnki.cjcmm.20170728.001

Deng Z, et al. [Standard Decoction of Leonuri Herba]. Zhongguo Zhong Yao Za Zhi. 2017;42(18):3523-3529. PubMed PMID: 29218937.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Standard decoction of Leonuri Herba]. AU - Deng,Zhe, AU - Zhang,Fan, AU - Zhang,Jun, AU - Zhang,Qing, AU - Jiao,Meng-Jiao, AU - Zhang,Guo-Yuan, AU - Cheng,Jin-Tang, AU - Liu,An, AU - Wang,Yue-Sheng, PY - 2017/06/18/received PY - 2017/12/9/entrez PY - 2017/12/9/pubmed PY - 2019/4/24/medline KW - Leonuri Herba KW - fingerprint KW - leonurine hydrochloride KW - stachydrine hydrochloride KW - standard decoction SP - 3523 EP - 3529 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 42 IS - 18 N2 - To build an evaluation standard for quality of Leonuri Herba standard decoction. 13 batches of Leonuri Herba standard decoction with different quality were prepared. The contents of leonurine hydrochloride and stachydrine hydrochloride were determined; then the transfer rate and the extract rate were calculated and pH value was measured; and HPLC fingerprint method was established for analysis. The results of 13 batches of samples revealed that the transfer rate of leonurine hydrochloride and stachydrine hydrochloride was 30.0%-53.4% and 67.0%-82.6%, respectively; the extract rate was 12.1%-18.3% and the pH value was 5.87-6.22. Moreover, 12 common chromatographic peaks were determined based on fingerprint by using Similarity Evaluation System for Chromatographic fingerprint of Traditional Chinese Medicine (2012A). The similarity of 13 batches of samples was analyzed and compared, and the results showed that the similarity was higher than 0.9. In this study, the preparation method for Leonuri Herba decoction was standard, with high similarity in fingerprint, showing high precision, stability and repeatability in fingerprint analysis. Thus, this study can provide a reference for the quality control of Leonuri Herba dispensing granules. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29218937/[Standard_decoction_of_Leonuri_Herba]_ DB - PRIME DP - Unbound Medicine ER -