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[Study on relationship between constitution and syndrome of MMP-9, IL-6 and MTHFR gene in patients with ischemic stroke].
Zhongguo Zhong Yao Za Zhi. 2017 Sep; 42(18):3602-3612.ZZ

Abstract

By studying the relationship between syndromes, physique and MMP-9, IL-6 and MTHFR gene polymorphisms in patients with ischemic stroke,The relationship between MMP-9, IL-6 and MTHFR gene polymorphism was analyzed in patients with ischemic stroke.The data were collected by collecting the data of patients with ischemic stroke, and the statistical analysis was carried out. Syndrome:61 cases of ischemic stroke patients with stroke phlegm stasis syndrome in patients with the highest frequency, a total of 30 cases; Physical constitution: phlegm is ischemic stroke patients prone to physical, a total of 20 cases; The analysis of the relationship between constitution and syndrome shows that the patients with qi deficiency constitution tend to show qi deficiency and blood stasis syndrome after onset, The analysis of the relationship between constitution and syndrome shows that the patients with qi deficiency constitution tend to show qi deficiency and blood stasis syndrome after onset, Phlegm constitution and physical condition after the onset of symptoms tend to wind phlegm stasis syndrome; Syndrome and MMP-9, IL-6 relationship:The distribution of MMP-9 and IL-6 in patients with qi and phlegm stasis syndrome and qi deficiency and blood stasis syndrome was significantly different from that in Z test (P<0.05). The level of MMP-9 in patients with qi deficiency and blood stasis syndrome was significantly higher than that in patients with wind phlegm and blood stasis syndrome;The level of IL-6 in patients with phlegm and blood stasis syndrome was significantly higher than that in patients with qi deficiency and blood stasis syndrome. Syndrome, constitution and MTHFR gene polymorphism: among the 61 samples, 34 were heterozygous mutations, 15 were pure and mutated, 12 had no mutation, The mutation rate of this locus was 4.08 times that of patients without mutations.The genotype of MTHFR C677T in patients with phlegm dampness tends to be CT genotype. Wind phlegm stasis syndrome in patients with easy to appear after the TT genotype; Yin deficiency syndrome in patients prone to miscellaneous and mutations, the performance of CT genotype; Analysis of the relationship between syndromes and physique in patients with ischemic stroke,Phlegm and dampness, flat quality patients after the onset of easy to show the wind phlegm stasis syndrome; Qi deficiency after the onset of symptoms in patients with Qi and blood stasis. Suggesting that before the onset of such as for the partial physical conditioning, may be on the prevention of ischemic stroke have a certain effect; Analysis of the relationship between syndromes and MMP-9 and IL-6 in patients with ischemic stroke, Wind phlegm stasis syndrome and IL-6 levels are related, Qi deficiency and blood stasis syndrome and MMP-9 levels are related. Analysis of the relationship between syndromes and MTHFR gene polymorphism in patients with ischemic stroke, TT genotype after the onset of symptoms prone to wind phlegm stasis syndrome, CT genotype patients after the onset of easy manifestations of Yin deficiency wind syndrome; Analysis of the relationship between physique and MTHFR gene polymorphism in patients with ischemic stroke, CT genotype is easy to show phlegm.For more in-depth understanding of pathogenesis of ischemic stroke to provide the basis, For the clinical treatment and prevention to provide intervention strategies.

Authors+Show Affiliations

Institute of Basic Research in Clinical Medicine, China Academy of Chineses Medical Sciences, Beijing 100700, China.Institute of Basic Research in Clinical Medicine, China Academy of Chineses Medical Sciences, Beijing 100700, China.Institute of Basic Research in Clinical Medicine, China Academy of Chineses Medical Sciences, Beijing 100700, China.Institute of Basic Research in Clinical Medicine, China Academy of Chineses Medical Sciences, Beijing 100700, China.Institute of Basic Research in Clinical Medicine, China Academy of Chineses Medical Sciences, Beijing 100700, China.Medical Experiment Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.Medical Experiment Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.Wuhan Branch, Beijing Liuhe Large Gene Technology Co., Ltd., Wuhan 430000, China.Wuhan Branch, Beijing Liuhe Large Gene Technology Co., Ltd., Wuhan 430000, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29218949

Citation

Sun, Shuai-Ling, et al. "[Study On Relationship Between Constitution and Syndrome of MMP-9, IL-6 and MTHFR Gene in Patients With Ischemic Stroke]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 42, no. 18, 2017, pp. 3602-3612.
Sun SL, Xie YM, Zhang Y, et al. [Study on relationship between constitution and syndrome of MMP-9, IL-6 and MTHFR gene in patients with ischemic stroke]. Zhongguo Zhong Yao Za Zhi. 2017;42(18):3602-3612.
Sun, S. L., Xie, Y. M., Zhang, Y., Wang, Z. F., Yang, J., Wang, D. Q., Jiao, Y., Chen, J., & Tao, Y. H. (2017). [Study on relationship between constitution and syndrome of MMP-9, IL-6 and MTHFR gene in patients with ischemic stroke]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(18), 3602-3612. https://doi.org/10.19540/j.cnki.cjcmm.2017.0139
Sun SL, et al. [Study On Relationship Between Constitution and Syndrome of MMP-9, IL-6 and MTHFR Gene in Patients With Ischemic Stroke]. Zhongguo Zhong Yao Za Zhi. 2017;42(18):3602-3612. PubMed PMID: 29218949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on relationship between constitution and syndrome of MMP-9, IL-6 and MTHFR gene in patients with ischemic stroke]. AU - Sun,Shuai-Ling, AU - Xie,Yan-Ming, AU - Zhang,Yin, AU - Wang,Zhi-Fei, AU - Yang,Jing, AU - Wang,Dan-Qiao, AU - Jiao,Yue, AU - Chen,Jun, AU - Tao,Yan-Hui, PY - 2017/06/28/received PY - 2017/12/9/entrez PY - 2017/12/9/pubmed PY - 2019/4/24/medline KW - MMP-9, IL-6, MTHFR gene polymorphism KW - ischemic stroke KW - physical KW - syndrome SP - 3602 EP - 3612 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 42 IS - 18 N2 - By studying the relationship between syndromes, physique and MMP-9, IL-6 and MTHFR gene polymorphisms in patients with ischemic stroke,The relationship between MMP-9, IL-6 and MTHFR gene polymorphism was analyzed in patients with ischemic stroke.The data were collected by collecting the data of patients with ischemic stroke, and the statistical analysis was carried out. Syndrome:61 cases of ischemic stroke patients with stroke phlegm stasis syndrome in patients with the highest frequency, a total of 30 cases; Physical constitution: phlegm is ischemic stroke patients prone to physical, a total of 20 cases; The analysis of the relationship between constitution and syndrome shows that the patients with qi deficiency constitution tend to show qi deficiency and blood stasis syndrome after onset, The analysis of the relationship between constitution and syndrome shows that the patients with qi deficiency constitution tend to show qi deficiency and blood stasis syndrome after onset, Phlegm constitution and physical condition after the onset of symptoms tend to wind phlegm stasis syndrome; Syndrome and MMP-9, IL-6 relationship:The distribution of MMP-9 and IL-6 in patients with qi and phlegm stasis syndrome and qi deficiency and blood stasis syndrome was significantly different from that in Z test (P<0.05). The level of MMP-9 in patients with qi deficiency and blood stasis syndrome was significantly higher than that in patients with wind phlegm and blood stasis syndrome;The level of IL-6 in patients with phlegm and blood stasis syndrome was significantly higher than that in patients with qi deficiency and blood stasis syndrome. Syndrome, constitution and MTHFR gene polymorphism: among the 61 samples, 34 were heterozygous mutations, 15 were pure and mutated, 12 had no mutation, The mutation rate of this locus was 4.08 times that of patients without mutations.The genotype of MTHFR C677T in patients with phlegm dampness tends to be CT genotype. Wind phlegm stasis syndrome in patients with easy to appear after the TT genotype; Yin deficiency syndrome in patients prone to miscellaneous and mutations, the performance of CT genotype; Analysis of the relationship between syndromes and physique in patients with ischemic stroke,Phlegm and dampness, flat quality patients after the onset of easy to show the wind phlegm stasis syndrome; Qi deficiency after the onset of symptoms in patients with Qi and blood stasis. Suggesting that before the onset of such as for the partial physical conditioning, may be on the prevention of ischemic stroke have a certain effect; Analysis of the relationship between syndromes and MMP-9 and IL-6 in patients with ischemic stroke, Wind phlegm stasis syndrome and IL-6 levels are related, Qi deficiency and blood stasis syndrome and MMP-9 levels are related. Analysis of the relationship between syndromes and MTHFR gene polymorphism in patients with ischemic stroke, TT genotype after the onset of symptoms prone to wind phlegm stasis syndrome, CT genotype patients after the onset of easy manifestations of Yin deficiency wind syndrome; Analysis of the relationship between physique and MTHFR gene polymorphism in patients with ischemic stroke, CT genotype is easy to show phlegm.For more in-depth understanding of pathogenesis of ischemic stroke to provide the basis, For the clinical treatment and prevention to provide intervention strategies. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29218949/[Study_on_relationship_between_constitution_and_syndrome_of_MMP_9_IL_6_and_MTHFR_gene_in_patients_with_ischemic_stroke]_ L2 - http://www.diseaseinfosearch.org/result/8683 DB - PRIME DP - Unbound Medicine ER -