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Role of extracellular vesicles in glioma progression.
Mol Aspects Med 2018; 60:38-51MA

Abstract

The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a considerable effort has been made to understand their biology. Studies focus in the signalling pathways involved in the processes of angiogenesis, viability, drug resistance and immune response evasion, as well as gliomas ability to infiltrate healthy tissue, a phenomenon regulated by the migratory and invasive capacity of the cells within a tumour. In this review, we summarize the different types and classifications of extracellular vesicles, their intravesicular content, and their role in the regulation of tumour progression processes in glioma.

Authors+Show Affiliations

Molecular Pathology Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile. Electronic address: claudiaquezada@uach.cl.Molecular Pathology Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.Molecular Pathology Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.Molecular Pathology Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Department of Basic Sciences, Faculty of Sciences, Universidad del Bío-Bío, Chillán 3780000, Chile.Molecular Pathology Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Cellular Signaling and Differentiation Laboratory (CSDL), School of Medical Technology, Health Sciences Faculty, Universidad San Sebastián, Santiago 7510157, Chile. Electronic address: jaime.gutierrez@uss.cl.Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland, Australia. Electronic address: lsobrevia@uc.cl.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29222067

Citation

Quezada, Claudia, et al. "Role of Extracellular Vesicles in Glioma Progression." Molecular Aspects of Medicine, vol. 60, 2018, pp. 38-51.
Quezada C, Torres Á, Niechi I, et al. Role of extracellular vesicles in glioma progression. Mol Aspects Med. 2018;60:38-51.
Quezada, C., Torres, Á., Niechi, I., Uribe, D., Contreras-Duarte, S., Toledo, F., ... Sobrevia, L. (2018). Role of extracellular vesicles in glioma progression. Molecular Aspects of Medicine, 60, pp. 38-51. doi:10.1016/j.mam.2017.12.003.
Quezada C, et al. Role of Extracellular Vesicles in Glioma Progression. Mol Aspects Med. 2018;60:38-51. PubMed PMID: 29222067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of extracellular vesicles in glioma progression. AU - Quezada,Claudia, AU - Torres,Ángelo, AU - Niechi,Ignacio, AU - Uribe,Daniel, AU - Contreras-Duarte,Susana, AU - Toledo,Fernando, AU - San Martín,Rody, AU - Gutiérrez,Jaime, AU - Sobrevia,Luis, Y1 - 2017/12/13/ PY - 2017/09/01/received PY - 2017/12/01/revised PY - 2017/12/04/accepted PY - 2017/12/10/pubmed PY - 2019/2/12/medline PY - 2017/12/10/entrez KW - Apoptotic bodies KW - Exosomes KW - Extracellular vesicles KW - Glioblastoma KW - Glioma KW - Large oncosomes KW - Microvesicles SP - 38 EP - 51 JF - Molecular aspects of medicine JO - Mol. Aspects Med. VL - 60 N2 - The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a considerable effort has been made to understand their biology. Studies focus in the signalling pathways involved in the processes of angiogenesis, viability, drug resistance and immune response evasion, as well as gliomas ability to infiltrate healthy tissue, a phenomenon regulated by the migratory and invasive capacity of the cells within a tumour. In this review, we summarize the different types and classifications of extracellular vesicles, their intravesicular content, and their role in the regulation of tumour progression processes in glioma. SN - 1872-9452 UR - https://www.unboundmedicine.com/medline/citation/29222067/Role_of_extracellular_vesicles_in_glioma_progression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0098-2997(17)30094-8 DB - PRIME DP - Unbound Medicine ER -