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An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia.
J Neurochem. 2018 03; 144(5):644-650.JN

Abstract

Vascular contributions to cognitive impairment and dementia (VCID) is understood to be the second most common cause of dementia after Alzheimer's disease, and is also a frequent comorbidity with Alzheimer's disease. While VCID is widely acknowledged as a key contributor to dementia, the mechanistic underpinnings of VCID remain poorly understood. In this review, we address the potential role of astrocytes in the pathophysiology of VCID. The vast majority of the blood vessels in the brain are surrounded by astrocytic end-feet. Given that astrocytes make up a significant proportion of the cells in the brain, and that astrocytes are usually passively connected to one another through gap junctions, we hypothesize that astrocytes are key mediators of cognitive impairment because of cerebrovascular disease. In this review, we discuss the existing body of literature regarding the role of astrocytes at the vasculature in the brain, and the known consequences of their dysfunction, as well as our hypotheses regarding the role astrocytes play in VCID. This article is part of the Special Issue "Vascular Dementia".

Authors+Show Affiliations

Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

29222909

Citation

Price, Brittani R., et al. "An Emerging Role of Astrocytes in Vascular Contributions to Cognitive Impairment and Dementia." Journal of Neurochemistry, vol. 144, no. 5, 2018, pp. 644-650.
Price BR, Norris CM, Sompol P, et al. An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia. J Neurochem. 2018;144(5):644-650.
Price, B. R., Norris, C. M., Sompol, P., & Wilcock, D. M. (2018). An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia. Journal of Neurochemistry, 144(5), 644-650. https://doi.org/10.1111/jnc.14273
Price BR, et al. An Emerging Role of Astrocytes in Vascular Contributions to Cognitive Impairment and Dementia. J Neurochem. 2018;144(5):644-650. PubMed PMID: 29222909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia. AU - Price,Brittani R, AU - Norris,Christopher M, AU - Sompol,Pradoldej, AU - Wilcock,Donna M, Y1 - 2018/01/22/ PY - 2017/07/07/received PY - 2017/10/30/revised PY - 2017/11/23/accepted PY - 2017/12/10/pubmed PY - 2019/3/2/medline PY - 2017/12/10/entrez KW - Alzheimer's disease KW - astrocyte KW - dementia KW - glia KW - neurodegeneration KW - vascular dementia SP - 644 EP - 650 JF - Journal of neurochemistry JO - J. Neurochem. VL - 144 IS - 5 N2 - Vascular contributions to cognitive impairment and dementia (VCID) is understood to be the second most common cause of dementia after Alzheimer's disease, and is also a frequent comorbidity with Alzheimer's disease. While VCID is widely acknowledged as a key contributor to dementia, the mechanistic underpinnings of VCID remain poorly understood. In this review, we address the potential role of astrocytes in the pathophysiology of VCID. The vast majority of the blood vessels in the brain are surrounded by astrocytic end-feet. Given that astrocytes make up a significant proportion of the cells in the brain, and that astrocytes are usually passively connected to one another through gap junctions, we hypothesize that astrocytes are key mediators of cognitive impairment because of cerebrovascular disease. In this review, we discuss the existing body of literature regarding the role of astrocytes at the vasculature in the brain, and the known consequences of their dysfunction, as well as our hypotheses regarding the role astrocytes play in VCID. This article is part of the Special Issue "Vascular Dementia". SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/29222909/An_emerging_role_of_astrocytes_in_vascular_contributions_to_cognitive_impairment_and_dementia_ L2 - https://doi.org/10.1111/jnc.14273 DB - PRIME DP - Unbound Medicine ER -