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Oxidation of iopamidol with ferrate (Fe(VI)): Kinetics and formation of toxic iodinated disinfection by-products.
Water Res. 2018 03 01; 130:200-207.WR

Abstract

Presence of iodinated X-ray contrast media (ICMs) in source water is of high concern, because of their potential to form highly toxic iodinated disinfection by-products (I-DBPs). This study investigated kinetics, mechanisms and products for oxidation of one ICMs, iopamidol (IPM) by ferrate (Fe(VI)). The obtained apparent second-order rate constants for oxidation of IPM by Fe(VI) ranged from 0.7 M-1 s-1 to 74.6 M-1 s-1 at pH 6.0-10.0, which were highly dependent on pH. It was found that the oxidation of IPM by Fe(VI) led to the formation of highly toxic I-DBPs. Iodoform (IF), iodoacetic acid and triiodoacetic acid formations were observed during the oxidation and IF dominated the formed I-DBPs. The formation of I-DBPs was also governed by pH and the maximum formation of I-DBPs occurred at pH 9.0. Transformation pathways of IPM by Fe(VI) oxidation were speculated to proceed through deiodination, amide hydrolysis and oxidation of amine reactions. The deiodination reaction during the oxidation of IPM by Fe(VI) contributed to the formation of I-DBPs. The formation of I-DBPs during the oxidation of IPM by Fe(VI) was significantly higher than those of iohexol, diatrizoate and iopromide, which was consistent with the lowest molecular orbital energy gap of IPM. Although Fe(VI) is considered as a green oxidant, the formation of highly toxic I-DBPs during the oxidation of IPM should receive great attention.

Authors+Show Affiliations

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 18 Shuang-qing Road, Beijing, 100085, China.Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 18 Shuang-qing Road, Beijing, 100085, China. Electronic address: qiangz@rcees.ac.cn.Guangxi Colleges and Universities Key Laboratory of Food Safety and Pharmaceutical Analytical Chemistry, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, 158 Da-xue Road, Nanning, 530006, Guangxi, China.School of Environmental Science and Engineering, Qingdao University, 308 Ning-xia Road, Qingdao, 266071, China.Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 18 Shuang-qing Road, Beijing, 100085, China.Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 18 Shuang-qing Road, Beijing, 100085, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29223090

Citation

Dong, Huiyu, et al. "Oxidation of Iopamidol With Ferrate (Fe(VI)): Kinetics and Formation of Toxic Iodinated Disinfection By-products." Water Research, vol. 130, 2018, pp. 200-207.
Dong H, Qiang Z, Liu S, et al. Oxidation of iopamidol with ferrate (Fe(VI)): Kinetics and formation of toxic iodinated disinfection by-products. Water Res. 2018;130:200-207.
Dong, H., Qiang, Z., Liu, S., Li, J., Yu, J., & Qu, J. (2018). Oxidation of iopamidol with ferrate (Fe(VI)): Kinetics and formation of toxic iodinated disinfection by-products. Water Research, 130, 200-207. https://doi.org/10.1016/j.watres.2017.12.003
Dong H, et al. Oxidation of Iopamidol With Ferrate (Fe(VI)): Kinetics and Formation of Toxic Iodinated Disinfection By-products. Water Res. 2018 03 1;130:200-207. PubMed PMID: 29223090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidation of iopamidol with ferrate (Fe(VI)): Kinetics and formation of toxic iodinated disinfection by-products. AU - Dong,Huiyu, AU - Qiang,Zhimin, AU - Liu,Shaogang, AU - Li,Jin, AU - Yu,Jianwei, AU - Qu,Jiuhui, Y1 - 2017/12/05/ PY - 2017/09/03/received PY - 2017/11/13/revised PY - 2017/12/04/accepted PY - 2017/12/10/pubmed PY - 2018/8/14/medline PY - 2017/12/10/entrez KW - Ferrate KW - Iodinated disinfection by-products KW - Iopamidol KW - Kinetics SP - 200 EP - 207 JF - Water research JO - Water Res VL - 130 N2 - Presence of iodinated X-ray contrast media (ICMs) in source water is of high concern, because of their potential to form highly toxic iodinated disinfection by-products (I-DBPs). This study investigated kinetics, mechanisms and products for oxidation of one ICMs, iopamidol (IPM) by ferrate (Fe(VI)). The obtained apparent second-order rate constants for oxidation of IPM by Fe(VI) ranged from 0.7 M-1 s-1 to 74.6 M-1 s-1 at pH 6.0-10.0, which were highly dependent on pH. It was found that the oxidation of IPM by Fe(VI) led to the formation of highly toxic I-DBPs. Iodoform (IF), iodoacetic acid and triiodoacetic acid formations were observed during the oxidation and IF dominated the formed I-DBPs. The formation of I-DBPs was also governed by pH and the maximum formation of I-DBPs occurred at pH 9.0. Transformation pathways of IPM by Fe(VI) oxidation were speculated to proceed through deiodination, amide hydrolysis and oxidation of amine reactions. The deiodination reaction during the oxidation of IPM by Fe(VI) contributed to the formation of I-DBPs. The formation of I-DBPs during the oxidation of IPM by Fe(VI) was significantly higher than those of iohexol, diatrizoate and iopromide, which was consistent with the lowest molecular orbital energy gap of IPM. Although Fe(VI) is considered as a green oxidant, the formation of highly toxic I-DBPs during the oxidation of IPM should receive great attention. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/29223090/Oxidation_of_iopamidol_with_ferrate__Fe_VI__:_Kinetics_and_formation_of_toxic_iodinated_disinfection_by_products_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(17)30998-3 DB - PRIME DP - Unbound Medicine ER -