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Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population.
Kidney Blood Press Res. 2017; 42(6):1141-1154.KB

Abstract

BACKGROUND/AIMS

Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood.

METHODS

This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria. Logistic regression models were used to examine the relationship between lipid variables and CKD.

RESULTS

The prevalence of CKD in this study was 3.7%. When the participants exhibited higher serum triglyceride (TG), a higher TG/high-density lipoprotein cholesterol (TG/HDL-c) ratio or a higher non-HDL-c/HDL-c ratio or HDL-c in a lower quartile, the prevalence of CKD tended to be higher. The multivariate adjusted odds ratios for CKD per 1 standard deviation increase in lipid level were 1.17 (1.10-1.23) for TG, 0.86 (0.79-0.93) for HDL-c, 1.21 (1.13-1.31) for the TG/HDL-c ratio, and 1.14 (1.06-1.22) for the non-HDL-c/HDL-c ratio. No significant association was detected between CKD and total cholesterol (TC), non-HDL-c or the low-density lipoprotein cholesterol/HDL-c (LDL-c/HDL-c) ratio.

CONCLUSION

In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.

Authors+Show Affiliations

Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China. Center of Clinical Pharmacology, The Third Xiangya Hospital of Central South University, Changsha, China.Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, China.Pharmacy Department of Ningbo City Medical Treatment Center, Lihuili Hospital, Ningbo, China.Center of Clinical Pharmacology, The Third Xiangya Hospital of Central South University, Changsha, China.Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China. Center of Clinical Pharmacology, The Third Xiangya Hospital of Central South University, Changsha, China.Institute of Clinical Pharmacology of Central South University, Changsha, China.Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China. Center of Clinical Pharmacology, The Third Xiangya Hospital of Central South University, Changsha, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29224024

Citation

Wen, Jia, et al. "Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios With Chronic Kidney Disease in an Adult Chinese Population." Kidney & Blood Pressure Research, vol. 42, no. 6, 2017, pp. 1141-1154.
Wen J, Chen Y, Huang Y, et al. Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population. Kidney Blood Press Res. 2017;42(6):1141-1154.
Wen, J., Chen, Y., Huang, Y., Lu, Y., Liu, X., Zhou, H., & Yuan, H. (2017). Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population. Kidney & Blood Pressure Research, 42(6), 1141-1154. https://doi.org/10.1159/000485861
Wen J, et al. Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios With Chronic Kidney Disease in an Adult Chinese Population. Kidney Blood Press Res. 2017;42(6):1141-1154. PubMed PMID: 29224024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population. AU - Wen,Jia, AU - Chen,Yiyin, AU - Huang,Yun, AU - Lu,Yao, AU - Liu,Xing, AU - Zhou,Honghao, AU - Yuan,Hong, Y1 - 2017/12/08/ PY - 2017/07/18/received PY - 2017/11/23/accepted PY - 2017/12/11/pubmed PY - 2018/8/31/medline PY - 2017/12/11/entrez KW - Chronic kidney disease KW - Dyslipidemia KW - High-density lipoprotein cholesterol KW - Non-HDL-c SP - 1141 EP - 1154 JF - Kidney & blood pressure research JO - Kidney Blood Press Res VL - 42 IS - 6 N2 - BACKGROUND/AIMS: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. METHODS: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria. Logistic regression models were used to examine the relationship between lipid variables and CKD. RESULTS: The prevalence of CKD in this study was 3.7%. When the participants exhibited higher serum triglyceride (TG), a higher TG/high-density lipoprotein cholesterol (TG/HDL-c) ratio or a higher non-HDL-c/HDL-c ratio or HDL-c in a lower quartile, the prevalence of CKD tended to be higher. The multivariate adjusted odds ratios for CKD per 1 standard deviation increase in lipid level were 1.17 (1.10-1.23) for TG, 0.86 (0.79-0.93) for HDL-c, 1.21 (1.13-1.31) for the TG/HDL-c ratio, and 1.14 (1.06-1.22) for the non-HDL-c/HDL-c ratio. No significant association was detected between CKD and total cholesterol (TC), non-HDL-c or the low-density lipoprotein cholesterol/HDL-c (LDL-c/HDL-c) ratio. CONCLUSION: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD. SN - 1423-0143 UR - https://www.unboundmedicine.com/medline/citation/29224024/Association_of_the_TG/HDL_C_and_Non_HDL_C/HDL_C_Ratios_with_Chronic_Kidney_Disease_in_an_Adult_Chinese_Population_ L2 - https://www.karger.com?DOI=10.1159/000485861 DB - PRIME DP - Unbound Medicine ER -