Tags

Type your tag names separated by a space and hit enter

Dorsal hippocampal cannabinergic and GABAergic systems modulate memory consolidation in passive avoidance task.
Brain Res Bull. 2018 03; 137:197-203.BR

Abstract

In the present research, we examined the possible interaction between the hippocampal CB2 and GABAA receptors on modulation of memory consolidation. In this research, step-down passive a . voidance task was used to evaluate memory consolidation in adult male NMRI mice. The results showed that post-training intra-CA1 administration of muscimol (0.05 and 0.1 μg/mouse) impaired memory consolidation as evidenced by a decrease in step-down latency on the test day, which was suggestive of drug-produced amnesia. However co-administration of different doses of muscimol (0.01, 0.05 and 0.1 μg/mouse) along with a not-effect dose of AM630 (1 μg/mouse) or GP1a (1 μg/mouse) had no significant effect on impairment of memory consolidation induced by muscimol. Although post-training intra-CA1 administration of the cannabinoid CB2 receptor antagonist, AM630 (1, 10 and 100 μg/mouse) alone had no effect, its co-administration with an effective dose of muscimol (0.05 μg/mouse) impaired memory consolidation. Furthermore, post-training intra-CA1 microinjection of cannabinoid CB2 receptor agonist, GP1a (100 μg/mouse) impaired memory consolidation. Interestingly, post-training intra-CA1 co-injection of different doses of GP1a (1, 10 and 100 μg/mouse) along with an effect dose of muscimol (0.05 μg/mouse) significantly intensified impairment of memory consolidation induced by GP1a (10 μg/mouse). Moreover, all above doses of drugs did not significantly change locomotor activity. These findings suggest possible interaction between the CA1 cannabinoid CB2 and GABAA mechanisms on modulation of memory consolidation in mice.

Authors+Show Affiliations

Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address: nasehi@iricss.org.Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: zarinmr@ams.ac.ir.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29225001

Citation

Nasehi, Mohammad, et al. "Dorsal Hippocampal Cannabinergic and GABAergic Systems Modulate Memory Consolidation in Passive Avoidance Task." Brain Research Bulletin, vol. 137, 2018, pp. 197-203.
Nasehi M, Gerami-Majd F, Khakpai F, et al. Dorsal hippocampal cannabinergic and GABAergic systems modulate memory consolidation in passive avoidance task. Brain Res Bull. 2018;137:197-203.
Nasehi, M., Gerami-Majd, F., Khakpai, F., & Zarrindast, M. R. (2018). Dorsal hippocampal cannabinergic and GABAergic systems modulate memory consolidation in passive avoidance task. Brain Research Bulletin, 137, 197-203. https://doi.org/10.1016/j.brainresbull.2017.11.017
Nasehi M, et al. Dorsal Hippocampal Cannabinergic and GABAergic Systems Modulate Memory Consolidation in Passive Avoidance Task. Brain Res Bull. 2018;137:197-203. PubMed PMID: 29225001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal hippocampal cannabinergic and GABAergic systems modulate memory consolidation in passive avoidance task. AU - Nasehi,Mohammad, AU - Gerami-Majd,Fatemeh, AU - Khakpai,Fatemeh, AU - Zarrindast,Mohammad-Reza, Y1 - 2017/12/07/ PY - 2017/09/14/received PY - 2017/11/15/revised PY - 2017/11/28/accepted PY - 2017/12/12/pubmed PY - 2018/9/1/medline PY - 2017/12/12/entrez KW - AM630 KW - GP1a KW - Memory consolidation KW - Muscimol KW - the CA1 SP - 197 EP - 203 JF - Brain research bulletin JO - Brain Res Bull VL - 137 N2 - In the present research, we examined the possible interaction between the hippocampal CB2 and GABAA receptors on modulation of memory consolidation. In this research, step-down passive a . voidance task was used to evaluate memory consolidation in adult male NMRI mice. The results showed that post-training intra-CA1 administration of muscimol (0.05 and 0.1 μg/mouse) impaired memory consolidation as evidenced by a decrease in step-down latency on the test day, which was suggestive of drug-produced amnesia. However co-administration of different doses of muscimol (0.01, 0.05 and 0.1 μg/mouse) along with a not-effect dose of AM630 (1 μg/mouse) or GP1a (1 μg/mouse) had no significant effect on impairment of memory consolidation induced by muscimol. Although post-training intra-CA1 administration of the cannabinoid CB2 receptor antagonist, AM630 (1, 10 and 100 μg/mouse) alone had no effect, its co-administration with an effective dose of muscimol (0.05 μg/mouse) impaired memory consolidation. Furthermore, post-training intra-CA1 microinjection of cannabinoid CB2 receptor agonist, GP1a (100 μg/mouse) impaired memory consolidation. Interestingly, post-training intra-CA1 co-injection of different doses of GP1a (1, 10 and 100 μg/mouse) along with an effect dose of muscimol (0.05 μg/mouse) significantly intensified impairment of memory consolidation induced by GP1a (10 μg/mouse). Moreover, all above doses of drugs did not significantly change locomotor activity. These findings suggest possible interaction between the CA1 cannabinoid CB2 and GABAA mechanisms on modulation of memory consolidation in mice. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/29225001/Dorsal_hippocampal_cannabinergic_and_GABAergic_systems_modulate_memory_consolidation_in_passive_avoidance_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(17)30553-1 DB - PRIME DP - Unbound Medicine ER -