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Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials.
Nutr Rev. 2018 02 01; 76(2):125-139.NR

Abstract

Context

The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent.

Objective

The present study aimed to systematically review and analyze randomized controlled trials assessing the effects of flaxseed consumption on glycemic control.

Data Sources

PubMed, Medline via Ovid, SCOPUS, EMBASE, and ISI Web of Sciences databases were searched up to November 2016.

Study Selection

Clinical trials in which flaxseed or its products were administered as an intervention were included.

Data Extraction

The outcomes were fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), insulin sensitivity (QUIKI), and hemoglobin A1c (HbA1c).

Results

A total of 25 randomized clinical trials (30 treatment arms) were included. Meta-analysis suggested a significant association between flaxseed supplementation and a reduction in blood glucose (weighted mean difference [WMD], -2.94 mg/dL; 95%CI, -5.31 to - 0.56; P = 0.015), insulin levels (WMD, -7.32 pmol/L; 95%CI, -11.66 to -2.97; P = 0.001), and HOMA-IR index (WMD, -0.49; 95%CI,: -0.78 to - 0.20; P = 0.001) and an increase in QUIKI index (WMD, 0.019; 95%CI, 0.008-0.031; P = 0.001). No significant effect on HbA1c (WMD, -0.045%; 95%CI, -0.16 to - 0.07; P = 0.468) was found. In subgroup analysis, a significant reduction in blood glucose, insulin, and HOMA-IR and a significant increase in QUIKI were found only in studies using whole flaxseed but not flaxseed oil and lignan extract. Furthermore, a significant reduction was observed in insulin levels and insulin sensitivity indexes only in the subset of trials lasting ≥12 weeks.

Conclusions

Whole flaxseed, but not flaxseed oil and lignan extract, has significant effects on improving glycemic control. Further studies are needed to determine the benefits of flaxseed on glycemic parameters.

Authors+Show Affiliations

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29228348

Citation

Mohammadi-Sartang, Mohsen, et al. "Flaxseed Supplementation On Glucose Control and Insulin Sensitivity: a Systematic Review and Meta-analysis of 25 Randomized, Placebo-controlled Trials." Nutrition Reviews, vol. 76, no. 2, 2018, pp. 125-139.
Mohammadi-Sartang M, Sohrabi Z, Barati-Boldaji R, et al. Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Nutr Rev. 2018;76(2):125-139.
Mohammadi-Sartang, M., Sohrabi, Z., Barati-Boldaji, R., Raeisi-Dehkordi, H., & Mazloom, Z. (2018). Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Nutrition Reviews, 76(2), 125-139. https://doi.org/10.1093/nutrit/nux052
Mohammadi-Sartang M, et al. Flaxseed Supplementation On Glucose Control and Insulin Sensitivity: a Systematic Review and Meta-analysis of 25 Randomized, Placebo-controlled Trials. Nutr Rev. 2018 02 1;76(2):125-139. PubMed PMID: 29228348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. AU - Mohammadi-Sartang,Mohsen, AU - Sohrabi,Zahra, AU - Barati-Boldaji,Reza, AU - Raeisi-Dehkordi,Hamidreza, AU - Mazloom,Zohreh, PY - 2017/12/12/pubmed PY - 2019/9/10/medline PY - 2017/12/12/entrez KW - flaxseed KW - glucose KW - insulin KW - insulin resistance KW - lignan SP - 125 EP - 139 JF - Nutrition reviews JO - Nutr. Rev. VL - 76 IS - 2 N2 - Context: The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent. Objective: The present study aimed to systematically review and analyze randomized controlled trials assessing the effects of flaxseed consumption on glycemic control. Data Sources: PubMed, Medline via Ovid, SCOPUS, EMBASE, and ISI Web of Sciences databases were searched up to November 2016. Study Selection: Clinical trials in which flaxseed or its products were administered as an intervention were included. Data Extraction: The outcomes were fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), insulin sensitivity (QUIKI), and hemoglobin A1c (HbA1c). Results: A total of 25 randomized clinical trials (30 treatment arms) were included. Meta-analysis suggested a significant association between flaxseed supplementation and a reduction in blood glucose (weighted mean difference [WMD], -2.94 mg/dL; 95%CI, -5.31 to - 0.56; P = 0.015), insulin levels (WMD, -7.32 pmol/L; 95%CI, -11.66 to -2.97; P = 0.001), and HOMA-IR index (WMD, -0.49; 95%CI,: -0.78 to - 0.20; P = 0.001) and an increase in QUIKI index (WMD, 0.019; 95%CI, 0.008-0.031; P = 0.001). No significant effect on HbA1c (WMD, -0.045%; 95%CI, -0.16 to - 0.07; P = 0.468) was found. In subgroup analysis, a significant reduction in blood glucose, insulin, and HOMA-IR and a significant increase in QUIKI were found only in studies using whole flaxseed but not flaxseed oil and lignan extract. Furthermore, a significant reduction was observed in insulin levels and insulin sensitivity indexes only in the subset of trials lasting ≥12 weeks. Conclusions: Whole flaxseed, but not flaxseed oil and lignan extract, has significant effects on improving glycemic control. Further studies are needed to determine the benefits of flaxseed on glycemic parameters. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/29228348/Flaxseed_supplementation_on_glucose_control_and_insulin_sensitivity:_a_systematic_review_and_meta_analysis_of_25_randomized_placebo_controlled_trials_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1093/nutrit/nux052 DB - PRIME DP - Unbound Medicine ER -