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Risk factors for acquisition of multidrug-resistant Escherichia coli and development of community-acquired urinary tract infections.
Epidemiol Infect. 2018 01; 146(1):46-57.EI

Abstract

We examined risk factors associated with the intestinal acquisition of antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) and development of community-acquired urinary tract infection (UTI) in a case-control study of young women across Canada. A total of 399 women were recruited; 164 women had a UTI caused by E. coli resistant to ⩾1 antimicrobial classes and 98 had a UTI caused by E. coli resistant to ⩾3 antimicrobial classes. After adjustment for age, student health service (region of Canada) and either prior antibiotic use or UTI history, consumption of processed or ground chicken, cooked or raw shellfish, street foods and any organic fruit; as well as, contact with chickens, dogs and pet treats; and travel to Asia, were associated with an increased risk of UTI caused by antimicrobial resistant E. coli. A decreased risk of antimicrobial resistant UTI was associated with consumption of apples, nectarines, peppers, fresh herbs, peanuts and cooked beef. Drug-resistant UTI linked to foodborne and environmental exposures may be a significant public health concern and understanding the risk factors for intestinal acquisition of existing or newly emerging lineages of drug-resistant ExPEC is important for epidemiology, antimicrobial stewardship and prevention efforts.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology,University of British Columbia,Vancouver,BC,Canada.School of Population and Public Health,University of British Columbia,Vancouver,BC,Canada.Centre for Foodborne,Environmental and Zoonotic Infectious Diseases,Public Health Agency of Canada,Guelph, ON,Canada.National Microbiology Laboratory,Public Health Agency of Canada,Saint-Hyacinthe,QC,Canada.Department of Medical Microbiology,University of Manitoba,Winnipeg,MB,Canada.Centre for Foodborne,Environmental and Zoonotic Infectious Diseases,Public Health Agency of Canada,Guelph, ON,Canada.Centre for Foodborne,Environmental and Zoonotic Infectious Diseases,Public Health Agency of Canada,Guelph, ON,Canada.The Research Institute of the McGill University Health Centre,Montréal,QC,Canada.Department of Pathobiology,University of Guelph,Guelph,ON,Canada.School of Population and Public Health,University of British Columbia,Vancouver,BC,Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29229015

Citation

Ukah, U V., et al. "Risk Factors for Acquisition of Multidrug-resistant Escherichia Coli and Development of Community-acquired Urinary Tract Infections." Epidemiology and Infection, vol. 146, no. 1, 2018, pp. 46-57.
Ukah UV, Glass M, Avery B, et al. Risk factors for acquisition of multidrug-resistant Escherichia coli and development of community-acquired urinary tract infections. Epidemiol Infect. 2018;146(1):46-57.
Ukah, U. V., Glass, M., Avery, B., Daignault, D., Mulvey, M. R., Reid-Smith, R. J., Parmley, E. J., Portt, A., Boerlin, P., & Manges, A. R. (2018). Risk factors for acquisition of multidrug-resistant Escherichia coli and development of community-acquired urinary tract infections. Epidemiology and Infection, 146(1), 46-57. https://doi.org/10.1017/S0950268817002680
Ukah UV, et al. Risk Factors for Acquisition of Multidrug-resistant Escherichia Coli and Development of Community-acquired Urinary Tract Infections. Epidemiol Infect. 2018;146(1):46-57. PubMed PMID: 29229015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for acquisition of multidrug-resistant Escherichia coli and development of community-acquired urinary tract infections. AU - Ukah,U V, AU - Glass,M, AU - Avery,B, AU - Daignault,D, AU - Mulvey,M R, AU - Reid-Smith,R J, AU - Parmley,E J, AU - Portt,A, AU - Boerlin,P, AU - Manges,A R, Y1 - 2017/12/12/ PY - 2017/12/13/pubmed PY - 2018/9/22/medline PY - 2017/12/13/entrez KW - Escherichia coli KW - Antimicrobial resistance KW - epidemiology KW - extraintestinal infections KW - extraintestinal pathogenic Escherichia coli KW - multidrug resistance KW - urinary tract infections SP - 46 EP - 57 JF - Epidemiology and infection JO - Epidemiol Infect VL - 146 IS - 1 N2 - We examined risk factors associated with the intestinal acquisition of antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) and development of community-acquired urinary tract infection (UTI) in a case-control study of young women across Canada. A total of 399 women were recruited; 164 women had a UTI caused by E. coli resistant to ⩾1 antimicrobial classes and 98 had a UTI caused by E. coli resistant to ⩾3 antimicrobial classes. After adjustment for age, student health service (region of Canada) and either prior antibiotic use or UTI history, consumption of processed or ground chicken, cooked or raw shellfish, street foods and any organic fruit; as well as, contact with chickens, dogs and pet treats; and travel to Asia, were associated with an increased risk of UTI caused by antimicrobial resistant E. coli. A decreased risk of antimicrobial resistant UTI was associated with consumption of apples, nectarines, peppers, fresh herbs, peanuts and cooked beef. Drug-resistant UTI linked to foodborne and environmental exposures may be a significant public health concern and understanding the risk factors for intestinal acquisition of existing or newly emerging lineages of drug-resistant ExPEC is important for epidemiology, antimicrobial stewardship and prevention efforts. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/29229015/Risk_factors_for_acquisition_of_multidrug_resistant_Escherichia_coli_and_development_of_community_acquired_urinary_tract_infections_ L2 - https://www.cambridge.org/core/product/identifier/S0950268817002680/type/journal_article DB - PRIME DP - Unbound Medicine ER -