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CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns.
Curr Top Med Chem. 2017; 17(30):3308-3315.CT

Abstract

A rapid search in scientific publication's databases shows how the use of CRISPR-Cas genome editions' technique has considerably expanded, and its growing importance, in modern molecular biology. Just in pub-med platform, the search of the term gives more than 3000 results. Specifically, in Drug Discovery, Medicinal Chemistry and Chemical Biology in general CRISPR method may have multiple applications. Some of these applications are: resistance-selection studies of antimalarial lead organic compounds; investigation of druggability; development of animal models for chemical compounds testing, etc. In this paper, we offer a review of the most relevant scientific literature illustrated with specific examples of application of CRISPR technique to medicinal chemistry and chemical biology. We also present a general overview of the main legal and ethical trends regarding this method of genome editing.

Authors+Show Affiliations

Department of Public Law, Law and the Human Genome Research Group, University of the Basque Country UPV/EHU, 48940, Leioa, Biscay, Spain.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29231142

Citation

Duardo-Sanchez, Aliuska. "CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns." Current Topics in Medicinal Chemistry, vol. 17, no. 30, 2017, pp. 3308-3315.
Duardo-Sanchez A. CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns. Curr Top Med Chem. 2017;17(30):3308-3315.
Duardo-Sanchez, A. (2017). CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns. Current Topics in Medicinal Chemistry, 17(30), 3308-3315. https://doi.org/10.2174/1568026618666171211151142
Duardo-Sanchez A. CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns. Curr Top Med Chem. 2017;17(30):3308-3315. PubMed PMID: 29231142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns. A1 - Duardo-Sanchez,Aliuska, PY - 2017/11/02/received PY - 2017/11/14/revised PY - 2017/11/22/accepted PY - 2017/12/13/pubmed PY - 2018/3/9/medline PY - 2017/12/13/entrez KW - CRISPR-Cas KW - Drug discovery KW - Gene editing legal issues. SP - 3308 EP - 3315 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 17 IS - 30 N2 - A rapid search in scientific publication's databases shows how the use of CRISPR-Cas genome editions' technique has considerably expanded, and its growing importance, in modern molecular biology. Just in pub-med platform, the search of the term gives more than 3000 results. Specifically, in Drug Discovery, Medicinal Chemistry and Chemical Biology in general CRISPR method may have multiple applications. Some of these applications are: resistance-selection studies of antimalarial lead organic compounds; investigation of druggability; development of animal models for chemical compounds testing, etc. In this paper, we offer a review of the most relevant scientific literature illustrated with specific examples of application of CRISPR technique to medicinal chemistry and chemical biology. We also present a general overview of the main legal and ethical trends regarding this method of genome editing. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/29231142/CRISPR_Cas_in_Medicinal_Chemistry:_Applications_and_Regulatory_Concerns_ L2 - http://www.eurekaselect.com/158203/article DB - PRIME DP - Unbound Medicine ER -