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[Clinical study on depression differentiated as yang deficiency treated with the combined therapy of ginger-isolated moxibustion and western medicine].
Zhongguo Zhen Jiu 2016; 36(12):1252-1256ZZ

Abstract

OBJECTIVE

To compare the differences in the clinical efficacy on depression differentiated as yang deficiency between the combined therapy of ginger-isolated moxibustion and escitalopram and the simple application escitalopram.

METHODS

Eighty patients of depression differentiated as yang deficiency were randomized into an observation group and a control group, 40 cases in each one. In the control group, escitalopram was prescribed for oral administration, 10 mg a day, after each breakfast. In the observation group, on the basis of the treatment as the control group, the ginger-isolated moxibustion was supplemented at Dazhui (GV 14) and bilateral back-shu points of five zang organs[Xinshu (BL 15), Ganshu (BL 18), Pishu (BL 20), Feishu (BL 13) and Shenshu (BL 23)]. Moxibustion was used 5 times a week. Twenty times of moxibustion were taken as one session and totally 3 sessions were required (totally 84 days). After 3 sessions of treatment, the concentration of serum 5-hydroxytryptamine (5-HT) before and after treatment and clinical efficacy were observed in the two groups. After 3 sessions of treatment, escitalopram was taken continuously, 10 mg a day for 9 months in the two groups and the recurrent rate was observed in a half year after discontinuity of medication in the two groups.

RESULTS

The total effective rate was 97.5% (39/40) in the observation group and was 92.5% (37/40) in the control group. The total effective rate was similar between the two groups (both P>0.05). The curative and remarkably effective rate was 82.5% (33/40) in the observation group, better than 62.5% (25/40) in the control group (P<0.05). The serum 5-HT after treatment was increased as compared with that before treatment in the patients of the two groups (both P<0.05), but the diffe-rence was not significant statistically between the two groups (P>0.05). The recurrent rate of depression was 7.7% (3/39) in the observation group, lower than 27.0% (10/37) in the control group (P<0.05).

CONCLUSIONS

The combined therapy of ginger-isolated moxibustion and escitalopram achieves the better curative and remarkably effective rate as compared with the simple western medicine and it significantly reduces the recurrence of depression.

Authors+Show Affiliations

Department of Integrated Chinese and Western Medicine, Xiamen Municipal Xianyue Hospital, Xiamen 361012, Fujian Province, China.Department of Integrated Chinese and Western Medicine, Xiamen Municipal Xianyue Hospital, Xiamen 361012, Fujian Province, China.Department of Integrated Chinese and Western Medicine, Xiamen Municipal Xianyue Hospital, Xiamen 361012, Fujian Province, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

29231361

Citation

Xie, Yanying, et al. "[Clinical Study On Depression Differentiated as Yang Deficiency Treated With the Combined Therapy of Ginger-isolated Moxibustion and Western Medicine]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 36, no. 12, 2016, pp. 1252-1256.
Xie Y, Liu L, Xie J. [Clinical study on depression differentiated as yang deficiency treated with the combined therapy of ginger-isolated moxibustion and western medicine]. Zhongguo Zhen Jiu. 2016;36(12):1252-1256.
Xie, Y., Liu, L., & Xie, J. (2016). [Clinical study on depression differentiated as yang deficiency treated with the combined therapy of ginger-isolated moxibustion and western medicine]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 36(12), pp. 1252-1256. doi:10.13703/j.0255-2930.2016.12.007.
Xie Y, Liu L, Xie J. [Clinical Study On Depression Differentiated as Yang Deficiency Treated With the Combined Therapy of Ginger-isolated Moxibustion and Western Medicine]. Zhongguo Zhen Jiu. 2016 Dec 12;36(12):1252-1256. PubMed PMID: 29231361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical study on depression differentiated as yang deficiency treated with the combined therapy of ginger-isolated moxibustion and western medicine]. AU - Xie,Yanying, AU - Liu,Liangsheng, AU - Xie,Jiajiang, PY - 2017/12/13/entrez PY - 2017/12/13/pubmed PY - 2018/6/21/medline KW - depression, yang deficiency KW - escitalopram KW - ginger-isolated moxibustion KW - randomized controlled trial (RCT) SP - 1252 EP - 1256 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 36 IS - 12 N2 - OBJECTIVE: To compare the differences in the clinical efficacy on depression differentiated as yang deficiency between the combined therapy of ginger-isolated moxibustion and escitalopram and the simple application escitalopram. METHODS: Eighty patients of depression differentiated as yang deficiency were randomized into an observation group and a control group, 40 cases in each one. In the control group, escitalopram was prescribed for oral administration, 10 mg a day, after each breakfast. In the observation group, on the basis of the treatment as the control group, the ginger-isolated moxibustion was supplemented at Dazhui (GV 14) and bilateral back-shu points of five zang organs[Xinshu (BL 15), Ganshu (BL 18), Pishu (BL 20), Feishu (BL 13) and Shenshu (BL 23)]. Moxibustion was used 5 times a week. Twenty times of moxibustion were taken as one session and totally 3 sessions were required (totally 84 days). After 3 sessions of treatment, the concentration of serum 5-hydroxytryptamine (5-HT) before and after treatment and clinical efficacy were observed in the two groups. After 3 sessions of treatment, escitalopram was taken continuously, 10 mg a day for 9 months in the two groups and the recurrent rate was observed in a half year after discontinuity of medication in the two groups. RESULTS: The total effective rate was 97.5% (39/40) in the observation group and was 92.5% (37/40) in the control group. The total effective rate was similar between the two groups (both P>0.05). The curative and remarkably effective rate was 82.5% (33/40) in the observation group, better than 62.5% (25/40) in the control group (P<0.05). The serum 5-HT after treatment was increased as compared with that before treatment in the patients of the two groups (both P<0.05), but the diffe-rence was not significant statistically between the two groups (P>0.05). The recurrent rate of depression was 7.7% (3/39) in the observation group, lower than 27.0% (10/37) in the control group (P<0.05). CONCLUSIONS: The combined therapy of ginger-isolated moxibustion and escitalopram achieves the better curative and remarkably effective rate as compared with the simple western medicine and it significantly reduces the recurrence of depression. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/29231361/[Clinical_study_on_depression_differentiated_as_yang_deficiency_treated_with_the_combined_therapy_of_ginger_isolated_moxibustion_and_western_medicine]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -