Tags

Type your tag names separated by a space and hit enter

Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis.
J Dig Dis 2018; 19(1):24-32JD

Abstract

OBJECTIVE

There is growing evidence that vitamin D deficiency plays a role in the development and the course of inflammatory bowel disease (IBD). However, the correlation between vitamin D deficiency and clinical parameters in IBD is still not completely understood.

METHODS

A retrospective study of IBD patients was performed. Vitamin D values were analyzed, regardless of vitamin D substitution administration, and correlated with clinical parameters such as medical therapy, anatomical situation, location of the disease and disease activity. Level of 25-hydroxyvitamin D [25(OH)D] <50 nmoL/L was regarded as vitamin D deficiency and <75 nmoL/L as insufficiency.

RESULTS

In total, 208 IBD patients were analyzed, including 123 with Crohn's disease (CD) and 85 with ulcerative colitis (UC). Therapy with azathioprine did not affect the vitamin D values of either disease entity. But CD patients benefited from therapy with tumor necrosis factor-α inhibitor and exhibited significantly higher vitamin D levels than those without. Furthermore, significantly lower vitamin D levels were found if CD was located in the small bowel or if the small bowel had been resected. Moreover, significantly lower levels of vitamin D were detectable for high disease activity (reflected by high simple clinical colitis activity index values) in patients with UC.

CONCLUSIONS

Vitamin D deficiency is common in patients with IBD. However, certain clinical situations lead to significantly lower vitamin D levels and may therefore require close monitoring for vitamin D deficiency.

Authors+Show Affiliations

Division of Gastroenterology, Department of Medicine II, University of Rostock, Rostock, Germany.Division of Gastroenterology, Department of Medicine II, University of Rostock, Rostock, Germany.Division of Gastroenterology, Department of Medicine II, University of Rostock, Rostock, Germany.Division of Gastroenterology, Department of Medicine II, University of Rostock, Rostock, Germany.Institute for Biostatistics and Informatics in Medicine, University of Rostock, Rostock, Germany.Division of Gastroenterology, Department of Medicine II, University of Rostock, Rostock, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29232067

Citation

Schäffler, Holger, et al. "Clinical Factors Are Associated With Vitamin D Levels in IBD Patients: a Retrospective Analysis." Journal of Digestive Diseases, vol. 19, no. 1, 2018, pp. 24-32.
Schäffler H, Schmidt M, Huth A, et al. Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis. J Dig Dis. 2018;19(1):24-32.
Schäffler, H., Schmidt, M., Huth, A., Reiner, J., Glass, Ä., & Lamprecht, G. (2018). Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis. Journal of Digestive Diseases, 19(1), pp. 24-32. doi:10.1111/1751-2980.12565.
Schäffler H, et al. Clinical Factors Are Associated With Vitamin D Levels in IBD Patients: a Retrospective Analysis. J Dig Dis. 2018;19(1):24-32. PubMed PMID: 29232067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis. AU - Schäffler,Holger, AU - Schmidt,Martin, AU - Huth,Astrid, AU - Reiner,Johannes, AU - Glass,Änne, AU - Lamprecht,Georg, PY - 2017/07/21/received PY - 2017/12/06/revised PY - 2017/12/08/accepted PY - 2017/12/13/pubmed PY - 2018/8/28/medline PY - 2017/12/13/entrez KW - Crohn disease KW - inflammatory bowel diseases KW - tumor necrosis factor-alpha KW - ulcerative colitis KW - vitamin D SP - 24 EP - 32 JF - Journal of digestive diseases JO - J Dig Dis VL - 19 IS - 1 N2 - OBJECTIVE: There is growing evidence that vitamin D deficiency plays a role in the development and the course of inflammatory bowel disease (IBD). However, the correlation between vitamin D deficiency and clinical parameters in IBD is still not completely understood. METHODS: A retrospective study of IBD patients was performed. Vitamin D values were analyzed, regardless of vitamin D substitution administration, and correlated with clinical parameters such as medical therapy, anatomical situation, location of the disease and disease activity. Level of 25-hydroxyvitamin D [25(OH)D] <50 nmoL/L was regarded as vitamin D deficiency and <75 nmoL/L as insufficiency. RESULTS: In total, 208 IBD patients were analyzed, including 123 with Crohn's disease (CD) and 85 with ulcerative colitis (UC). Therapy with azathioprine did not affect the vitamin D values of either disease entity. But CD patients benefited from therapy with tumor necrosis factor-α inhibitor and exhibited significantly higher vitamin D levels than those without. Furthermore, significantly lower vitamin D levels were found if CD was located in the small bowel or if the small bowel had been resected. Moreover, significantly lower levels of vitamin D were detectable for high disease activity (reflected by high simple clinical colitis activity index values) in patients with UC. CONCLUSIONS: Vitamin D deficiency is common in patients with IBD. However, certain clinical situations lead to significantly lower vitamin D levels and may therefore require close monitoring for vitamin D deficiency. SN - 1751-2980 UR - https://www.unboundmedicine.com/medline/citation/29232067/Clinical_factors_are_associated_with_vitamin_D_levels_in_IBD_patients:_A_retrospective_analysis_ L2 - https://doi.org/10.1111/1751-2980.12565 DB - PRIME DP - Unbound Medicine ER -