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[Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro].
Zhongguo Zhong Yao Za Zhi. 2017 Oct; 42(19):3764-3769.ZZ

Abstract

The present work is to study the chemical constituents from petroleum ether fraction of Tibetan medicine Swertia chirayita by column chromatography and recrystallization. The structures were identified by physical and chemical properties and spectral data as swerchirin (1), decussatin (2), 1,8-dihydroxy-3,5,7-trimethoxyxanthone (3), 1-hydroxy-3,5,7,8-tetramethoxyxanthone (4), bellidifolin (5), 1-hydroxy-3, 7-dimethoxyxanthone (6), methylswertianin (7), 1-hydroxy-3,5-dimethoxyxanthone (8), erythrodiol (9), oleanolic acid (10), gnetiolactone (11), scopoletin (12), sinapaldehyde (13), syringaldehyde (14), and β-sitosterol (15). Compounds 3, 4, 9, 11-14 were isolated from S. chirayita for the first time. Compounds 9 and 12 were firstly isolated from the genus Swertia. The cytotoxic activities of compounds 1, 2, 5, 7 and 8 against human pancreatic cancer cell lines SW1990 and BxPC-3,and the protective effects of these compounds against hydrogen peroxide (H2O2)-induced oxidative stress in human endothelium-derived EA.hy926 were investigated in vitro. The results showed no obvious effect at the high concentration of 50 μmol•L⁻¹.

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Publisher Full Text (DOI)

Authors+Show Affiliations

You RR
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.
Chen XQ
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.
He DD
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.
Huang CG
School of Pharmacy, Nanjing Medical University, Nanjing 211116, China.
Jin Y
School of Pharmacy, Nanjing Medical University, Nanjing 211116, China.
Qian SH
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Nanjing 210014, China.
Ju JM
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China. Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Nanjing 210014, China.
Fan JT
School of Pharmacy, Nanjing Medical University, Nanjing 211116, China.

MeSH

AcroleinAlkanesBenzaldehydesCell Line, TumorDrugs, Chinese HerbalHumansHydrogen PeroxideOleanolic AcidOxidative StressPhytochemicalsPlant ExtractsScopoletinSitosterolsSwertiaXanthones

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29235293

Citation

You, Rong-Rong, et al. "[Chemical Constituents From Petroleum Ether Fraction of Swertia Chirayita and Their Activities in Vitro]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 42, no. 19, 2017, pp. 3764-3769.
You RR, Chen XQ, He DD, et al. [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong Yao Za Zhi. 2017;42(19):3764-3769.
You, R. R., Chen, X. Q., He, D. D., Huang, C. G., Jin, Y., Qian, S. H., Ju, J. M., & Fan, J. T. (2017). [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(19), 3764-3769. https://doi.org/10.19540/j.cnki.cjcmm.20170807.003
You RR, et al. [Chemical Constituents From Petroleum Ether Fraction of Swertia Chirayita and Their Activities in Vitro]. Zhongguo Zhong Yao Za Zhi. 2017;42(19):3764-3769. PubMed PMID: 29235293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. AU - You,Rong-Rong, AU - Chen,Xue-Qing, AU - He,Dan-Dan, AU - Huang,Chang-Gao, AU - Jin,Yang, AU - Qian,Shi-Hui, AU - Ju,Jian-Ming, AU - Fan,Jun-Ting, PY - 2017/06/29/received PY - 2017/12/14/entrez PY - 2017/12/14/pubmed PY - 2019/5/6/medline KW - Swertia chirayita KW - chemical constituents KW - oxidative stress damage KW - pancreatic cancer cells KW - petroleum ether fraction KW - xanthone SP - 3764 EP - 3769 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 42 IS - 19 N2 - The present work is to study the chemical constituents from petroleum ether fraction of Tibetan medicine Swertia chirayita by column chromatography and recrystallization. The structures were identified by physical and chemical properties and spectral data as swerchirin (1), decussatin (2), 1,8-dihydroxy-3,5,7-trimethoxyxanthone (3), 1-hydroxy-3,5,7,8-tetramethoxyxanthone (4), bellidifolin (5), 1-hydroxy-3, 7-dimethoxyxanthone (6), methylswertianin (7), 1-hydroxy-3,5-dimethoxyxanthone (8), erythrodiol (9), oleanolic acid (10), gnetiolactone (11), scopoletin (12), sinapaldehyde (13), syringaldehyde (14), and β-sitosterol (15). Compounds 3, 4, 9, 11-14 were isolated from S. chirayita for the first time. Compounds 9 and 12 were firstly isolated from the genus Swertia. The cytotoxic activities of compounds 1, 2, 5, 7 and 8 against human pancreatic cancer cell lines SW1990 and BxPC-3,and the protective effects of these compounds against hydrogen peroxide (H2O2)-induced oxidative stress in human endothelium-derived EA.hy926 were investigated in vitro. The results showed no obvious effect at the high concentration of 50 μmol•L⁻¹. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29235293/[Chemical_constituents_from_petroleum_ether_fraction_of_Swertia_chirayita_and_their_activities_in_vitro]_ DB - PRIME DP - Unbound Medicine ER -