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The chronic exposure to abamectin causes spatial memory deficit and depressive behavior in mice.
Chemosphere. 2018 Mar; 194:523-533.C

Abstract

It is known that abamectin (ABA), which is a component belonging to the group of avermectins, has been broadly used as biopesticide. Although its effect on non-target aquatic organisms is known, knowledge about its impacts on terrestrial animals such as mammals remains incipient. Thus, we aim at investigating the effects (phycical and neural-behavioral) from the chronic exposure (90 days) to ABA (1/10 of LD50) on Swiss and C57Bl/6J mice from both sexes. Accordingly, at the end of the experimental period the animals were subjected to the following tests: Novel Object Recognition Test (NORT), Morris Water Maze (MWM), Tail Suspension Test (TST), and Forced Swimming Test (FST). We showed that the new-object recognition indexes in the NORT test sessions did not differ between experimental groups; however, animals exposed to ABA, regardless of sex or strain, recorded longer latency time to find the quadrant holding the platform in the MWM training sessions, as well as stayed shorter in this quadrant. Such results highlight the negative effect of the pesticide on the animals' spatial memory evocation, without evident influence from their genetic status and sex. With regard to TST, we also did not observe differences in immobility time between groups; however, Swiss mice (males and females) presented depressive behavior in the FST, and apparent influence from their genetic status in their responses during the test. Therefore, our study confirms the neurotoxic potential of ABA and is pioneer in reporting memory deficit and depressive behavior in mammal experimental models.

Authors+Show Affiliations

Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado and Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado and Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado and Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado and Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado and Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado and Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Electronic address: guilhermeifgoiano@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29241126

Citation

da Silva, Wellington Alves Mizael, et al. "The Chronic Exposure to Abamectin Causes Spatial Memory Deficit and Depressive Behavior in Mice." Chemosphere, vol. 194, 2018, pp. 523-533.
da Silva WAM, Guimarães ATB, Montalvão MF, et al. The chronic exposure to abamectin causes spatial memory deficit and depressive behavior in mice. Chemosphere. 2018;194:523-533.
da Silva, W. A. M., Guimarães, A. T. B., Montalvão, M. F., Mendes, B. O., Rodrigues, A. S. L., & Malafaia, G. (2018). The chronic exposure to abamectin causes spatial memory deficit and depressive behavior in mice. Chemosphere, 194, 523-533. https://doi.org/10.1016/j.chemosphere.2017.12.028
da Silva WAM, et al. The Chronic Exposure to Abamectin Causes Spatial Memory Deficit and Depressive Behavior in Mice. Chemosphere. 2018;194:523-533. PubMed PMID: 29241126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chronic exposure to abamectin causes spatial memory deficit and depressive behavior in mice. AU - da Silva,Wellington Alves Mizael, AU - Guimarães,Abraão Tiago Batista, AU - Montalvão,Mateus Flores, AU - Mendes,Bruna de Oliveira, AU - Rodrigues,Aline Sueli de Lima, AU - Malafaia,Guilherme, Y1 - 2017/12/07/ PY - 2017/10/07/received PY - 2017/11/29/revised PY - 2017/12/05/accepted PY - 2017/12/15/pubmed PY - 2018/4/3/medline PY - 2017/12/15/entrez KW - Behavior KW - Biopesticide KW - Mammals KW - Pesticides SP - 523 EP - 533 JF - Chemosphere JO - Chemosphere VL - 194 N2 - It is known that abamectin (ABA), which is a component belonging to the group of avermectins, has been broadly used as biopesticide. Although its effect on non-target aquatic organisms is known, knowledge about its impacts on terrestrial animals such as mammals remains incipient. Thus, we aim at investigating the effects (phycical and neural-behavioral) from the chronic exposure (90 days) to ABA (1/10 of LD50) on Swiss and C57Bl/6J mice from both sexes. Accordingly, at the end of the experimental period the animals were subjected to the following tests: Novel Object Recognition Test (NORT), Morris Water Maze (MWM), Tail Suspension Test (TST), and Forced Swimming Test (FST). We showed that the new-object recognition indexes in the NORT test sessions did not differ between experimental groups; however, animals exposed to ABA, regardless of sex or strain, recorded longer latency time to find the quadrant holding the platform in the MWM training sessions, as well as stayed shorter in this quadrant. Such results highlight the negative effect of the pesticide on the animals' spatial memory evocation, without evident influence from their genetic status and sex. With regard to TST, we also did not observe differences in immobility time between groups; however, Swiss mice (males and females) presented depressive behavior in the FST, and apparent influence from their genetic status in their responses during the test. Therefore, our study confirms the neurotoxic potential of ABA and is pioneer in reporting memory deficit and depressive behavior in mammal experimental models. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/29241126/The_chronic_exposure_to_abamectin_causes_spatial_memory_deficit_and_depressive_behavior_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(17)31989-6 DB - PRIME DP - Unbound Medicine ER -