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Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease.
Neurosci Lett. 2018 02 05; 665:236-239.NL

Abstract

DJ-1 is one of the important genes found in Parkinson's disease (PD). Studies have shown that the DJ-1 protein levels are elevated in the cerebrospinal fluid (CSF) and plasma of sporadic PD patients, and the DJ-1 protein levels in the CSF and plasma may serve as biomarkers of PD. However, Japanese scholars previously reported that there was no difference in the levels of the DJ-1 protein in serum between sporadic PD patients and controls. Therefore, whether the serum DJ-1 protein levels are different between PD patients and controls in Chinese patients as well as whether serum DJ-1 protein can serve as a biomarker of PD are unknown. The present study aimed to determine whether there was a difference in serum DJ-1 protein levels between Chinese PD patients and controls. The subjects included 18 primary PD patients and 7 controls. Blood was collected by venipuncture, and serum was collected by centrifugation after the blood was coagulated. The serum DJ-1 protein levels were detected by both Western blot and ELISA. There were differences in the serum DJ-1 protein levels among different individuals. The serum DJ-1 concentration in PD patients was 11.3±10.1ng/ml, and that in controls was 18.1±12.8ng/ml (P>0.05). In conclusion, similar to the study conducted by Japanese scholars, we found no significant difference in the serum DJ-1 protein levels between PD patients and controls in Chinese subjects. The levels of the DJ-1 protein in serum may not be a biomarker of PD. In addition, there may be differences in the serum DJ-1 protein levels between Chinese and Japanese patients.

Authors+Show Affiliations

Department of Pharmacology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, China.Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, China.Department of Neurology, Peking University Third Hospital, Beijing, China.Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, 10 West 1st Road, Outer of Youanmen, Beijing 100069, China. Electronic address: zhang_hn2008@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29241707

Citation

An, Chunna, et al. "Expression of the DJ-1 Protein in the Serum of Chinese Patients With Parkinson's Disease." Neuroscience Letters, vol. 665, 2018, pp. 236-239.
An C, Pu X, Xiao W, et al. Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease. Neurosci Lett. 2018;665:236-239.
An, C., Pu, X., Xiao, W., & Zhang, H. (2018). Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease. Neuroscience Letters, 665, 236-239. https://doi.org/10.1016/j.neulet.2017.12.023
An C, et al. Expression of the DJ-1 Protein in the Serum of Chinese Patients With Parkinson's Disease. Neurosci Lett. 2018 02 5;665:236-239. PubMed PMID: 29241707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease. AU - An,Chunna, AU - Pu,Xiaoping, AU - Xiao,Weizhong, AU - Zhang,Hongning, Y1 - 2017/12/11/ PY - 2017/09/10/received PY - 2017/10/31/revised PY - 2017/12/10/accepted PY - 2017/12/16/pubmed PY - 2018/11/16/medline PY - 2017/12/16/entrez KW - Chinese KW - DJ-1 KW - Parkinson's disease KW - Serum SP - 236 EP - 239 JF - Neuroscience letters JO - Neurosci Lett VL - 665 N2 - DJ-1 is one of the important genes found in Parkinson's disease (PD). Studies have shown that the DJ-1 protein levels are elevated in the cerebrospinal fluid (CSF) and plasma of sporadic PD patients, and the DJ-1 protein levels in the CSF and plasma may serve as biomarkers of PD. However, Japanese scholars previously reported that there was no difference in the levels of the DJ-1 protein in serum between sporadic PD patients and controls. Therefore, whether the serum DJ-1 protein levels are different between PD patients and controls in Chinese patients as well as whether serum DJ-1 protein can serve as a biomarker of PD are unknown. The present study aimed to determine whether there was a difference in serum DJ-1 protein levels between Chinese PD patients and controls. The subjects included 18 primary PD patients and 7 controls. Blood was collected by venipuncture, and serum was collected by centrifugation after the blood was coagulated. The serum DJ-1 protein levels were detected by both Western blot and ELISA. There were differences in the serum DJ-1 protein levels among different individuals. The serum DJ-1 concentration in PD patients was 11.3±10.1ng/ml, and that in controls was 18.1±12.8ng/ml (P>0.05). In conclusion, similar to the study conducted by Japanese scholars, we found no significant difference in the serum DJ-1 protein levels between PD patients and controls in Chinese subjects. The levels of the DJ-1 protein in serum may not be a biomarker of PD. In addition, there may be differences in the serum DJ-1 protein levels between Chinese and Japanese patients. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/29241707/Expression_of_the_DJ_1_protein_in_the_serum_of_Chinese_patients_with_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(17)30996-5 DB - PRIME DP - Unbound Medicine ER -