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Zika virus: The transboundary pathogen from mosquito and updates.
Microb Pathog. 2018 Jan; 114:476-482.MP

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that was relatively obscure until outbreaks started in 2013. ZIKV is associated with neurological manifestations such as Guillan-Barrè Syndrome in adult and microcephaly in the newborn population. Although the majority of disease mechanisms of ZIKV is unclear, some information was updated with new scientific evidence. Currently, there are no approved drugs or vaccine that can be used for therapy during ZIKV infection. Based on the transmission mechanism of ZIKV, vector control and safe sex seem to be the most effective available preventive measures against ZIKV spread. This study summarized the current ZIKV epidemiology, the status of the existing pathogenic mechanism of ZIKV, the development of potential compounds and vaccines against ZIKV, and the control efforts against ZIKV.

Authors+Show Affiliations

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, 14642, USA. Electronic address: weili_kong@urmc.rochester.edu.Edmund A. Hajim School of Engineering and Applied Sciences, University of Rochester, USA.Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, 14642, USA; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29241768

Citation

Kong, Weili, et al. "Zika Virus: the Transboundary Pathogen From Mosquito and Updates." Microbial Pathogenesis, vol. 114, 2018, pp. 476-482.
Kong W, Li H, Zhu J. Zika virus: The transboundary pathogen from mosquito and updates. Microb Pathog. 2018;114:476-482.
Kong, W., Li, H., & Zhu, J. (2018). Zika virus: The transboundary pathogen from mosquito and updates. Microbial Pathogenesis, 114, 476-482. https://doi.org/10.1016/j.micpath.2017.12.031
Kong W, Li H, Zhu J. Zika Virus: the Transboundary Pathogen From Mosquito and Updates. Microb Pathog. 2018;114:476-482. PubMed PMID: 29241768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zika virus: The transboundary pathogen from mosquito and updates. AU - Kong,Weili, AU - Li,Hengtao, AU - Zhu,Jian, Y1 - 2017/12/11/ PY - 2017/09/14/received PY - 2017/12/08/revised PY - 2017/12/09/accepted PY - 2017/12/16/pubmed PY - 2018/8/14/medline PY - 2017/12/16/entrez KW - Epidemiology KW - Genetic mutation KW - Microcephaly KW - Molecular pathogenesis KW - Prevention KW - Zika virus SP - 476 EP - 482 JF - Microbial pathogenesis JO - Microb. Pathog. VL - 114 N2 - Zika virus (ZIKV) is a mosquito-borne flavivirus that was relatively obscure until outbreaks started in 2013. ZIKV is associated with neurological manifestations such as Guillan-Barrè Syndrome in adult and microcephaly in the newborn population. Although the majority of disease mechanisms of ZIKV is unclear, some information was updated with new scientific evidence. Currently, there are no approved drugs or vaccine that can be used for therapy during ZIKV infection. Based on the transmission mechanism of ZIKV, vector control and safe sex seem to be the most effective available preventive measures against ZIKV spread. This study summarized the current ZIKV epidemiology, the status of the existing pathogenic mechanism of ZIKV, the development of potential compounds and vaccines against ZIKV, and the control efforts against ZIKV. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/29241768/Zika_virus:_The_transboundary_pathogen_from_mosquito_and_updates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(17)31165-8 DB - PRIME DP - Unbound Medicine ER -