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Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma?
Invest Ophthalmol Vis Sci. 2017 12 01; 58(14):6257-6264.IO

Abstract

Purpose

To determine the usefulness of swept-source optical coherence tomography (SS-OCT) probability maps in detecting locations with significant reduction in visual field (VF) sensitivity or predicting future VF changes, in patients with classically defined preperimetric glaucoma (PPG).

Methods

Of 43 PPG patients, 43 eyes were followed-up on every 6 months for at least 2 years were analyzed in this longitudinal study. The patients underwent wide-field SS-OCT scanning and standard automated perimetry (SAP) at the time of enrollment. With this wide-scan protocol, probability maps originating from the corresponding thickness map and overlapped with SAP VF test points could be generated. We evaluated the vulnerable VF points with SS-OCT probability maps as well as the prevalence of locations with significant VF reduction or subsequent VF changes observed in the corresponding damaged areas of the probability maps.

Results

The vulnerable VF points were shown in superior and inferior arcuate patterns near the central fixation. In 19 of 43 PPG eyes (44.2%), significant reduction in baseline VF was detected within the areas of structural change on the SS-OCT probability maps. In 16 of 43 PPG eyes (37.2%), subsequent VF changes within the areas of SS-OCT probability map change were observed over the course of the follow-up.

Conclusions

Structural changes on SS-OCT probability maps could detect or predict VF changes using SAP, in a considerable number of PPG eyes. Careful comparison of probability maps with SAP results could be useful in diagnosing and monitoring PPG patients in the clinical setting.

Authors+Show Affiliations

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29242899

Citation

Lee, Won June, et al. "Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma?" Investigative Ophthalmology & Visual Science, vol. 58, no. 14, 2017, pp. 6257-6264.
Lee WJ, Kim YK, Jeoung JW, et al. Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma? Invest Ophthalmol Vis Sci. 2017;58(14):6257-6264.
Lee, W. J., Kim, Y. K., Jeoung, J. W., & Park, K. H. (2017). Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma? Investigative Ophthalmology & Visual Science, 58(14), 6257-6264. https://doi.org/10.1167/iovs.17-22697
Lee WJ, et al. Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma. Invest Ophthalmol Vis Sci. 2017 12 1;58(14):6257-6264. PubMed PMID: 29242899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma? AU - Lee,Won June, AU - Kim,Young Kook, AU - Jeoung,Jin Wook, AU - Park,Ki Ho, PY - 2017/12/16/entrez PY - 2017/12/16/pubmed PY - 2017/12/28/medline SP - 6257 EP - 6264 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 58 IS - 14 N2 - Purpose: To determine the usefulness of swept-source optical coherence tomography (SS-OCT) probability maps in detecting locations with significant reduction in visual field (VF) sensitivity or predicting future VF changes, in patients with classically defined preperimetric glaucoma (PPG). Methods: Of 43 PPG patients, 43 eyes were followed-up on every 6 months for at least 2 years were analyzed in this longitudinal study. The patients underwent wide-field SS-OCT scanning and standard automated perimetry (SAP) at the time of enrollment. With this wide-scan protocol, probability maps originating from the corresponding thickness map and overlapped with SAP VF test points could be generated. We evaluated the vulnerable VF points with SS-OCT probability maps as well as the prevalence of locations with significant VF reduction or subsequent VF changes observed in the corresponding damaged areas of the probability maps. Results: The vulnerable VF points were shown in superior and inferior arcuate patterns near the central fixation. In 19 of 43 PPG eyes (44.2%), significant reduction in baseline VF was detected within the areas of structural change on the SS-OCT probability maps. In 16 of 43 PPG eyes (37.2%), subsequent VF changes within the areas of SS-OCT probability map change were observed over the course of the follow-up. Conclusions: Structural changes on SS-OCT probability maps could detect or predict VF changes using SAP, in a considerable number of PPG eyes. Careful comparison of probability maps with SAP results could be useful in diagnosing and monitoring PPG patients in the clinical setting. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/29242899/Can_Probability_Maps_of_Swept_Source_Optical_Coherence_Tomography_Predict_Visual_Field_Changes_in_Preperimetric_Glaucoma L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.17-22697 DB - PRIME DP - Unbound Medicine ER -