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Alcohol consumption and breast cancer-specific and all-cause mortality in women diagnosed with breast cancer at the New York site of the Breast Cancer Family Registry.
PLoS One. 2017; 12(12):e0189118.Plos

Abstract

PURPOSE

Alcohol consumption is an established and important risk factor for breast cancer incidence in the general population. However, the relationship between alcohol and mortality among women with breast cancer is less clear. This study examines the effect of alcohol consumption on mortality in women affected with breast cancer at baseline from a high-risk family breast and ovarian cancer registry.

METHODS

We studied 1116 women affected with breast cancer at baseline from the Metropolitan New York Registry. The examined reported alcohol consumption (total of beer, wine, liquor) was defined as the average number of drinks per week reported from age 12 to age at baseline. We assessed vital status of each participant using participant or family reported data and we used the National Death Index to supplement deaths reported through family updates. We used Cox proportional hazards models to estimate the association between alcohol intake and overall mortality (HRO), breast cancer-specific mortality (HRBC), and non-breast cancer mortality (HRNBC), adjusted for confounders.

RESULTS

After a mean follow-up of 9.1 years, we observed 211 total deaths and 58 breast cancer deaths. Compared to non-drinkers, we found that both low and moderate to heavy levels of alcohol intake were not associated with greater overall mortality (≤3 drinks/week: HRO: 0.66, 95% CI: 0.38-1.14); > 3 drinks/week: HRO: 1.16, 95% CI: 0.85-1.58), breast cancer-specific mortality (≤ 3 drinks/week: HRBC:0.62, 95% CI: 0.19-2.03; >3 drinks/week: HR BC: 0.96, 95% CI: 0.49-1.89), or non-breast cancer-specific mortality (≤3 drinks/week: HR NBC: 0.73, 95% CI: 0.32-1.6; >3 drinks/week: HRNBC: 1.18, 95% CI: 0.75-1.86).

CONCLUSIONS

Alcohol intake reported from age 12 to age at baseline was not associated with overall or breast cancer-specific mortality in this cohort of affected women with a family history of breast cancer.

Authors+Show Affiliations

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America.Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America.Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America.Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America.Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America.Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America. Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, United States of America.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29244822

Citation

Zeinomar, Nur, et al. "Alcohol Consumption and Breast Cancer-specific and All-cause Mortality in Women Diagnosed With Breast Cancer at the New York Site of the Breast Cancer Family Registry." PloS One, vol. 12, no. 12, 2017, pp. e0189118.
Zeinomar N, Thai A, Cloud AJ, et al. Alcohol consumption and breast cancer-specific and all-cause mortality in women diagnosed with breast cancer at the New York site of the Breast Cancer Family Registry. PLoS ONE. 2017;12(12):e0189118.
Zeinomar, N., Thai, A., Cloud, A. J., McDonald, J. A., Liao, Y., & Terry, M. B. (2017). Alcohol consumption and breast cancer-specific and all-cause mortality in women diagnosed with breast cancer at the New York site of the Breast Cancer Family Registry. PloS One, 12(12), e0189118. https://doi.org/10.1371/journal.pone.0189118
Zeinomar N, et al. Alcohol Consumption and Breast Cancer-specific and All-cause Mortality in Women Diagnosed With Breast Cancer at the New York Site of the Breast Cancer Family Registry. PLoS ONE. 2017;12(12):e0189118. PubMed PMID: 29244822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and breast cancer-specific and all-cause mortality in women diagnosed with breast cancer at the New York site of the Breast Cancer Family Registry. AU - Zeinomar,Nur, AU - Thai,Ashley, AU - Cloud,Ann J, AU - McDonald,Jasmine A, AU - Liao,Yuyan, AU - Terry,Mary Beth, Y1 - 2017/12/15/ PY - 2017/06/23/received PY - 2017/11/20/accepted PY - 2017/12/16/entrez PY - 2017/12/16/pubmed PY - 2018/1/9/medline SP - e0189118 EP - e0189118 JF - PloS one JO - PLoS ONE VL - 12 IS - 12 N2 - PURPOSE: Alcohol consumption is an established and important risk factor for breast cancer incidence in the general population. However, the relationship between alcohol and mortality among women with breast cancer is less clear. This study examines the effect of alcohol consumption on mortality in women affected with breast cancer at baseline from a high-risk family breast and ovarian cancer registry. METHODS: We studied 1116 women affected with breast cancer at baseline from the Metropolitan New York Registry. The examined reported alcohol consumption (total of beer, wine, liquor) was defined as the average number of drinks per week reported from age 12 to age at baseline. We assessed vital status of each participant using participant or family reported data and we used the National Death Index to supplement deaths reported through family updates. We used Cox proportional hazards models to estimate the association between alcohol intake and overall mortality (HRO), breast cancer-specific mortality (HRBC), and non-breast cancer mortality (HRNBC), adjusted for confounders. RESULTS: After a mean follow-up of 9.1 years, we observed 211 total deaths and 58 breast cancer deaths. Compared to non-drinkers, we found that both low and moderate to heavy levels of alcohol intake were not associated with greater overall mortality (≤3 drinks/week: HRO: 0.66, 95% CI: 0.38-1.14); > 3 drinks/week: HRO: 1.16, 95% CI: 0.85-1.58), breast cancer-specific mortality (≤ 3 drinks/week: HRBC:0.62, 95% CI: 0.19-2.03; >3 drinks/week: HR BC: 0.96, 95% CI: 0.49-1.89), or non-breast cancer-specific mortality (≤3 drinks/week: HR NBC: 0.73, 95% CI: 0.32-1.6; >3 drinks/week: HRNBC: 1.18, 95% CI: 0.75-1.86). CONCLUSIONS: Alcohol intake reported from age 12 to age at baseline was not associated with overall or breast cancer-specific mortality in this cohort of affected women with a family history of breast cancer. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/29244822/Alcohol_consumption_and_breast_cancer_specific_and_all_cause_mortality_in_women_diagnosed_with_breast_cancer_at_the_New_York_site_of_the_Breast_Cancer_Family_Registry_ L2 - http://dx.plos.org/10.1371/journal.pone.0189118 DB - PRIME DP - Unbound Medicine ER -