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Factors influencing psychological well-being in patients with Parkinson's disease.
PLoS One. 2017; 12(12):e0189682.Plos

Abstract

BACKGROUND

Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale.

OBJECTIVES

To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates.

METHODS

This article reports data of patients' perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relationship between well-being and clinical characteristics including fatigue, depression, sleep disruption and HRQoL.

RESULTS

272 patients completed the PWS questionnaire. Significant and clinically-relevant correlations were found between PWS total score and Parkinson's Fatigue Scale, Beck Depression Inventory, UPDRS Section I, PD Sleep Scale and PDQ-39 for HRQoL scores. Only clinically negligible correlations were found between PWS and motor scores.

CONCLUSIONS

Non-motor symptoms have a significant impact on psychological well-being in PD patients.

Authors+Show Affiliations

Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy.Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy.Institute of Neurology, IRCCS San Raffaele Pisana, Rome, Italy.Centre for Parkinson's Disease and Movement Disorders, DINOGMI, University of Genoa, Genoa, Italy.Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy. DIBINEM, Alma Mater Studiorum, University of Bologna, Bologna, Italy.Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.Department of Neurorehabilitation, Parkinson Operative Unit, San Raffaele Institute, Cassino (FR), Italy.Department of Neurology and Psychiatry, and IRCSS Neuromed, La Sapienza University of Rome, Rome, Italy.Parkinson's Disease and Movement Disorders Unit, IRCCS Neurological National Institute C. Mondino, Pavia, Italy.Parkinson Institute, ASST G. Pini-CTO, Milan, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Parkinson Institute, ASST G. Pini-CTO, Milan, Italy.Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29244834

Citation

Nicoletti, Alessandra, et al. "Factors Influencing Psychological Well-being in Patients With Parkinson's Disease." PloS One, vol. 12, no. 12, 2017, pp. e0189682.
Nicoletti A, Mostile G, Stocchi F, et al. Factors influencing psychological well-being in patients with Parkinson's disease. PLoS One. 2017;12(12):e0189682.
Nicoletti, A., Mostile, G., Stocchi, F., Abbruzzese, G., Ceravolo, R., Cortelli, P., D'Amelio, M., De Pandis, M. F., Fabbrini, G., Pacchetti, C., Pezzoli, G., Tessitore, A., Canesi, M., & Zappia, M. (2017). Factors influencing psychological well-being in patients with Parkinson's disease. PloS One, 12(12), e0189682. https://doi.org/10.1371/journal.pone.0189682
Nicoletti A, et al. Factors Influencing Psychological Well-being in Patients With Parkinson's Disease. PLoS One. 2017;12(12):e0189682. PubMed PMID: 29244834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors influencing psychological well-being in patients with Parkinson's disease. AU - Nicoletti,Alessandra, AU - Mostile,Giovanni, AU - Stocchi,Fabrizio, AU - Abbruzzese,Giovanni, AU - Ceravolo,Roberto, AU - Cortelli,Pietro, AU - D'Amelio,Marco, AU - De Pandis,Maria F, AU - Fabbrini,Giovanni, AU - Pacchetti,Claudio, AU - Pezzoli,Gianni, AU - Tessitore,Alessandro, AU - Canesi,Margherita, AU - Zappia,Mario, Y1 - 2017/12/15/ PY - 2017/03/16/received PY - 2017/11/30/accepted PY - 2017/12/16/entrez PY - 2017/12/16/pubmed PY - 2018/1/3/medline SP - e0189682 EP - e0189682 JF - PloS one JO - PLoS One VL - 12 IS - 12 N2 - BACKGROUND: Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. OBJECTIVES: To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates. METHODS: This article reports data of patients' perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relationship between well-being and clinical characteristics including fatigue, depression, sleep disruption and HRQoL. RESULTS: 272 patients completed the PWS questionnaire. Significant and clinically-relevant correlations were found between PWS total score and Parkinson's Fatigue Scale, Beck Depression Inventory, UPDRS Section I, PD Sleep Scale and PDQ-39 for HRQoL scores. Only clinically negligible correlations were found between PWS and motor scores. CONCLUSIONS: Non-motor symptoms have a significant impact on psychological well-being in PD patients. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/29244834/Factors_influencing_psychological_well_being_in_patients_with_Parkinson's_disease_ L2 - https://dx.plos.org/10.1371/journal.pone.0189682 DB - PRIME DP - Unbound Medicine ER -