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Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health.
Environ Sci Pollut Res Int. 2018 Nov; 25(32):31885-31894.ES

Abstract

Organochlorine pesticides (OCPs) were determined by gas chromatography in 241 placentas from cotton-growing regions, 121 placentas from an urban area (city of Osh), and 146 placentas from unpolluted mountain regions of Kyrgyzstan. Manifestations of disease were recorded in the mothers during pregnancy and parturition and in their newborns during the first 6 days of life. OCPs were detected in 240 out of 508 placentas (47.2%), with increased incidence in the two polluted regions (65%), particularly in placentas from women living near former pesticide storehouses and agro air-strips (99%), but only in 2.7% of placentas from the unpolluted region. α-, β-, and γ-hexachlorocyclohexane (HCH); DDT; DDE; aldrin; and heptachlor were detected. The sum of concentrations of all OCPs (total OCPs) was calculated for each of the 240 placentas with detectable OCPs (median 9.5 μg/kg placenta, mean 88.3 μg/kg, range 0.1-3070 μg/kg). The incidence of health problems in four subgroups of this data set, with increasing levels of total OCPs, was compared with the incidence of health problems in the group of 268 placentas, where OCPs were undetectable. Relative risk of health problems in both, mothers and newborns, increased significantly, in a concentration-dependent manner, with increasing levels of total OCPs (p < 0.0001). Health complications with increased incidence in OCP-exposed newborns included, i.a., low birth weight, congenital malformations, infections, and stillbirths, in OCP-exposed mothers preterm delivery, (pre-)eclampsia/gestosis, and frequency of hospitalizations after delivery (infections). Women living near former pesticide storehouses and agro airstrips should be considered as being at risk. Reduction of exposure is urgently needed.

Authors+Show Affiliations

Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan. impnankr@gmail.com.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, 723504, Osh, Kyrgyzstan.GREEN Tox GmbH, Langackerstrasse 49, CH-8057, Zürich, Switzerland.POPs Environmental Consulting, Lindenfirststr. 23, 73527, Schwäbisch Gmünd, Germany. roland.weber10@web.de.GREEN Tox GmbH, Langackerstrasse 49, CH-8057, Zürich, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29247409

Citation

Toichuev, Rakhmanbek Mamatkadyrovich, et al. "Organochlorine Pesticides in Placenta in Kyrgyzstan and the Effect On Pregnancy, Childbirth, and Newborn Health." Environmental Science and Pollution Research International, vol. 25, no. 32, 2018, pp. 31885-31894.
Toichuev RM, Zhilova LV, Paizildaev TR, et al. Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. Environ Sci Pollut Res Int. 2018;25(32):31885-31894.
Toichuev, R. M., Zhilova, L. V., Paizildaev, T. R., Khametova, M. S., Rakhmatillaev, A., Sakibaev, K. S., Madykova, Z. A., Toichueva, A. U., Schlumpf, M., Weber, R., & Lichtensteiger, W. (2018). Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. Environmental Science and Pollution Research International, 25(32), 31885-31894. https://doi.org/10.1007/s11356-017-0962-6
Toichuev RM, et al. Organochlorine Pesticides in Placenta in Kyrgyzstan and the Effect On Pregnancy, Childbirth, and Newborn Health. Environ Sci Pollut Res Int. 2018;25(32):31885-31894. PubMed PMID: 29247409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. AU - Toichuev,Rakhmanbek Mamatkadyrovich, AU - Zhilova,Liudmila Victorovna, AU - Paizildaev,Timur Rashidinovich, AU - Khametova,Madina Shavkatovna, AU - Rakhmatillaev,Abdygapar, AU - Sakibaev,Kyialbek Sherikbaevich, AU - Madykova,Zhanyl Akhmedovna, AU - Toichueva,Asel Uezbekovna, AU - Schlumpf,Margret, AU - Weber,Roland, AU - Lichtensteiger,Walter, Y1 - 2017/12/15/ PY - 2017/04/18/received PY - 2017/12/06/accepted PY - 2017/12/17/pubmed PY - 2019/1/15/medline PY - 2017/12/17/entrez KW - Adverse effects KW - Agro airstrip KW - Kyrgyzstan KW - Newborn KW - Organochlorine pesticides KW - Pesticide landfill KW - Pesticide storehouse KW - Placenta KW - Pregnancy SP - 31885 EP - 31894 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 25 IS - 32 N2 - Organochlorine pesticides (OCPs) were determined by gas chromatography in 241 placentas from cotton-growing regions, 121 placentas from an urban area (city of Osh), and 146 placentas from unpolluted mountain regions of Kyrgyzstan. Manifestations of disease were recorded in the mothers during pregnancy and parturition and in their newborns during the first 6 days of life. OCPs were detected in 240 out of 508 placentas (47.2%), with increased incidence in the two polluted regions (65%), particularly in placentas from women living near former pesticide storehouses and agro air-strips (99%), but only in 2.7% of placentas from the unpolluted region. α-, β-, and γ-hexachlorocyclohexane (HCH); DDT; DDE; aldrin; and heptachlor were detected. The sum of concentrations of all OCPs (total OCPs) was calculated for each of the 240 placentas with detectable OCPs (median 9.5 μg/kg placenta, mean 88.3 μg/kg, range 0.1-3070 μg/kg). The incidence of health problems in four subgroups of this data set, with increasing levels of total OCPs, was compared with the incidence of health problems in the group of 268 placentas, where OCPs were undetectable. Relative risk of health problems in both, mothers and newborns, increased significantly, in a concentration-dependent manner, with increasing levels of total OCPs (p < 0.0001). Health complications with increased incidence in OCP-exposed newborns included, i.a., low birth weight, congenital malformations, infections, and stillbirths, in OCP-exposed mothers preterm delivery, (pre-)eclampsia/gestosis, and frequency of hospitalizations after delivery (infections). Women living near former pesticide storehouses and agro airstrips should be considered as being at risk. Reduction of exposure is urgently needed. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/29247409/Organochlorine_pesticides_in_placenta_in_Kyrgyzstan_and_the_effect_on_pregnancy,_childbirth,_and_newborn_health L2 - https://dx.doi.org/10.1007/s11356-017-0962-6 DB - PRIME DP - Unbound Medicine ER -