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The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes.
Biochim Biophys Acta Mol Basis Dis 2018; 1864(3):758-763BB

Abstract

BACKGROUND AND AIMS

KLOTHO is an anti-ageing circulating hormone involved in insulin signaling, inflammation and vascular homeostasis through its protective effects on the endothelium and antioxidant actions. The common functional "KL-VS" variant of the KLOTHO gene is reproducibly associated with longevity in humans. Large number of studies have evaluated close relationship between KLOTHO protein and diabetes but the association between KL-VS variant and retinopathy in type 1 diabetes mellitus (T1D) is unknown. Therefore, in the present study we examined the association between the KL-VS polymorphism and the risk of diabetic retinopathy (DR) in patients with T1D.

METHODS

We examined 400 patients with T1D and 350 healthy age-matched controls. The analysis concerned KL-VS polymorphism along with the levels of serum inflammatory (CRP, TNF-α) and anti-inflammatory (IL-10) markers, pro-angiogenic (angiogenin) and anti-angiogenic interferon gamma-induced protein 10 (IP-10) factors as well as adhesion molecules (ICAM-1, ICAM-3).

RESULTS

We did not find significant association between T1D and KL-VS alleles. However, we observed that the incidence of KL-VS genotype is lower in a group with retinopathy in comparison to diabetic patients without this complication. Moreover, we established that KL-VS carriers had the lowest levels of inflammatory markers, pro-angiogenic factors and adhesion molecules. Simultaneously, the KL-VS carriers had increased serum levels of anti-inflammatory and anti-angiogenic cytokines than holders bearing wild type genotype.

CONCLUSIONS

In conclusion, the findings of our studies suggest that the functional KL-VS variant of the KLOTHO gene protects against the development of retinopathy in patients with T1D.

Authors+Show Affiliations

Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland. Electronic address: bartosz@gumed.edu.pl.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29247834

Citation

Słomiński, Bartosz, et al. "The KL-VS Polymorphism of KLOTHO Gene Is Protective Against Retinopathy Incidence in Patients With Type 1 Diabetes." Biochimica Et Biophysica Acta. Molecular Basis of Disease, vol. 1864, no. 3, 2018, pp. 758-763.
Słomiński B, Ryba-Stanisławowska M, Skrzypkowska M, et al. The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes. Biochim Biophys Acta Mol Basis Dis. 2018;1864(3):758-763.
Słomiński, B., Ryba-Stanisławowska, M., Skrzypkowska, M., Myśliwska, J., & Myśliwiec, M. (2018). The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 1864(3), pp. 758-763. doi:10.1016/j.bbadis.2017.12.015.
Słomiński B, et al. The KL-VS Polymorphism of KLOTHO Gene Is Protective Against Retinopathy Incidence in Patients With Type 1 Diabetes. Biochim Biophys Acta Mol Basis Dis. 2018;1864(3):758-763. PubMed PMID: 29247834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes. AU - Słomiński,Bartosz, AU - Ryba-Stanisławowska,Monika, AU - Skrzypkowska,Maria, AU - Myśliwska,Jolanta, AU - Myśliwiec,Małgorzata, Y1 - 2017/12/13/ PY - 2017/10/12/received PY - 2017/12/04/revised PY - 2017/12/11/accepted PY - 2017/12/17/pubmed PY - 2018/4/24/medline PY - 2017/12/17/entrez KW - Diabetes retinopathy KW - Inflammation KW - KL-VS polymorphism SP - 758 EP - 763 JF - Biochimica et biophysica acta. Molecular basis of disease JO - Biochim Biophys Acta Mol Basis Dis VL - 1864 IS - 3 N2 - BACKGROUND AND AIMS: KLOTHO is an anti-ageing circulating hormone involved in insulin signaling, inflammation and vascular homeostasis through its protective effects on the endothelium and antioxidant actions. The common functional "KL-VS" variant of the KLOTHO gene is reproducibly associated with longevity in humans. Large number of studies have evaluated close relationship between KLOTHO protein and diabetes but the association between KL-VS variant and retinopathy in type 1 diabetes mellitus (T1D) is unknown. Therefore, in the present study we examined the association between the KL-VS polymorphism and the risk of diabetic retinopathy (DR) in patients with T1D. METHODS: We examined 400 patients with T1D and 350 healthy age-matched controls. The analysis concerned KL-VS polymorphism along with the levels of serum inflammatory (CRP, TNF-α) and anti-inflammatory (IL-10) markers, pro-angiogenic (angiogenin) and anti-angiogenic interferon gamma-induced protein 10 (IP-10) factors as well as adhesion molecules (ICAM-1, ICAM-3). RESULTS: We did not find significant association between T1D and KL-VS alleles. However, we observed that the incidence of KL-VS genotype is lower in a group with retinopathy in comparison to diabetic patients without this complication. Moreover, we established that KL-VS carriers had the lowest levels of inflammatory markers, pro-angiogenic factors and adhesion molecules. Simultaneously, the KL-VS carriers had increased serum levels of anti-inflammatory and anti-angiogenic cytokines than holders bearing wild type genotype. CONCLUSIONS: In conclusion, the findings of our studies suggest that the functional KL-VS variant of the KLOTHO gene protects against the development of retinopathy in patients with T1D. SN - 0925-4439 UR - https://www.unboundmedicine.com/medline/citation/29247834/The_KL_VS_polymorphism_of_KLOTHO_gene_is_protective_against_retinopathy_incidence_in_patients_with_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(17)30464-7 DB - PRIME DP - Unbound Medicine ER -