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Suspected anaphylaxis and lack of clinical protection associated with envenomation in two dogs previously vaccinated with Crotalus atrox toxoid.
Toxicon. 2018 Feb; 142:30-33.T

Abstract

OBJECTIVE

to describe the clinical presentation of two canines present in anaphylactic shock secondary to rattlesnake envenomation. In both cases, there was no previous documented previous envenomation event and the initial sensitization required for anaphylactic response is believed to be secondary to Crotalus atrox toxoid vaccine.

CASE DESCRIPTION

In the first case, a 12-year-old golden retriever present for collapse, severe hematochezia, and vomiting after first time envenomation from a suspected western diamondback rattlesnake. The patient presented in severe hypovolemic shock and required aggressive fluid therapy, antivenom, anti-emetics, and pain management. The patient made a full recovery within 24 hours. In the second case, an 8-year old English setter presented for acute collapse, vomiting, and facial swelling after suspected first time envenomation from a suspected Prairie rattlesnake. The patient presented in severe hypovolemic shock with cardiac arrhythmias and required aggressive fluid therapy, antivenom, pain control, anti-emetics, and antibiotics. The patient made a full recovery after three days of hospitalization. Both patients had been previously vaccinated with the C. atrox vaccine.

CONCLUSION

This case report documents suspected anaphylaxis in two canine patients after first time envenomation by a rattlesnake. Both patients were previously vaccinated by the Crotalus atrox toxoid, which is hypothesized to be the initial inciting trigger.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Petras KE
Arizona Veterinary Emergency and Critical Care Center, USA. Electronic address: kaelyn.petras@azervets.com.
Wells RJ
Phoenix Veterinary Referral and Emergency Center, USA.
Pronko J
Colorado State University, USA.

MeSH

AnaphylaxisAnimalsAntiveninsCrotalid VenomsDog DiseasesDogsFemaleMaleSnake BitesVaccination

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29248468

Citation

Petras, Kaelyn E., et al. "Suspected Anaphylaxis and Lack of Clinical Protection Associated With Envenomation in Two Dogs Previously Vaccinated With Crotalus Atrox Toxoid." Toxicon : Official Journal of the International Society On Toxinology, vol. 142, 2018, pp. 30-33.
Petras KE, Wells RJ, Pronko J. Suspected anaphylaxis and lack of clinical protection associated with envenomation in two dogs previously vaccinated with Crotalus atrox toxoid. Toxicon. 2018;142:30-33.
Petras, K. E., Wells, R. J., & Pronko, J. (2018). Suspected anaphylaxis and lack of clinical protection associated with envenomation in two dogs previously vaccinated with Crotalus atrox toxoid. Toxicon : Official Journal of the International Society On Toxinology, 142, 30-33. https://doi.org/10.1016/j.toxicon.2017.12.044
Petras KE, Wells RJ, Pronko J. Suspected Anaphylaxis and Lack of Clinical Protection Associated With Envenomation in Two Dogs Previously Vaccinated With Crotalus Atrox Toxoid. Toxicon. 2018;142:30-33. PubMed PMID: 29248468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suspected anaphylaxis and lack of clinical protection associated with envenomation in two dogs previously vaccinated with Crotalus atrox toxoid. AU - Petras,Kaelyn E, AU - Wells,Raegan J, AU - Pronko,Jocelyn, Y1 - 2017/12/14/ PY - 2017/09/06/received PY - 2017/12/11/revised PY - 2017/12/13/accepted PY - 2017/12/19/pubmed PY - 2018/11/15/medline PY - 2017/12/18/entrez KW - Anaphylaxis KW - Rattlesnake envenomation SP - 30 EP - 33 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 142 N2 - OBJECTIVE: to describe the clinical presentation of two canines present in anaphylactic shock secondary to rattlesnake envenomation. In both cases, there was no previous documented previous envenomation event and the initial sensitization required for anaphylactic response is believed to be secondary to Crotalus atrox toxoid vaccine. CASE DESCRIPTION: In the first case, a 12-year-old golden retriever present for collapse, severe hematochezia, and vomiting after first time envenomation from a suspected western diamondback rattlesnake. The patient presented in severe hypovolemic shock and required aggressive fluid therapy, antivenom, anti-emetics, and pain management. The patient made a full recovery within 24 hours. In the second case, an 8-year old English setter presented for acute collapse, vomiting, and facial swelling after suspected first time envenomation from a suspected Prairie rattlesnake. The patient presented in severe hypovolemic shock with cardiac arrhythmias and required aggressive fluid therapy, antivenom, pain control, anti-emetics, and antibiotics. The patient made a full recovery after three days of hospitalization. Both patients had been previously vaccinated with the C. atrox vaccine. CONCLUSION: This case report documents suspected anaphylaxis in two canine patients after first time envenomation by a rattlesnake. Both patients were previously vaccinated by the Crotalus atrox toxoid, which is hypothesized to be the initial inciting trigger. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/29248468/Suspected_anaphylaxis_and_lack_of_clinical_protection_associated_with_envenomation_in_two_dogs_previously_vaccinated_with_Crotalus_atrox_toxoid_ DB - PRIME DP - Unbound Medicine ER -