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H2S and polysulfide metabolism: Conventional and unconventional pathways.
Biochem Pharmacol. 2018 03; 149:77-90.BP

Abstract

It is now well established that hydrogen sulfide (H2S) is an effector of a wide variety of physiological processes. It is also clear that many of the effects of H2S are mediated through reactions with cysteine sulfur on regulatory proteins and most of these are not mediated directly by H2S but require prior oxidation of H2S and the formation of per- and polysulfides (H2Sn, n = 2-8). Attendant with understanding the regulatory functions of H2S and H2Sn is an appreciation of the mechanisms that control, i.e., both increase and decrease, their production and catabolism. Although a number of standard "conventional" pathways have been described and well characterized, novel "unconventional" pathways are continuously being identified. This review summarizes our current knowledge of both the conventional and unconventional.

Authors+Show Affiliations

Indiana University School of Medicine - South Bend, South Bend, IN 46617, USA. Electronic address: kolson@nd.edu.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

29248597

Citation

Olson, Kenneth R.. "H2S and Polysulfide Metabolism: Conventional and Unconventional Pathways." Biochemical Pharmacology, vol. 149, 2018, pp. 77-90.
Olson KR. H2S and polysulfide metabolism: Conventional and unconventional pathways. Biochem Pharmacol. 2018;149:77-90.
Olson, K. R. (2018). H2S and polysulfide metabolism: Conventional and unconventional pathways. Biochemical Pharmacology, 149, 77-90. https://doi.org/10.1016/j.bcp.2017.12.010
Olson KR. H2S and Polysulfide Metabolism: Conventional and Unconventional Pathways. Biochem Pharmacol. 2018;149:77-90. PubMed PMID: 29248597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - H2S and polysulfide metabolism: Conventional and unconventional pathways. A1 - Olson,Kenneth R, Y1 - 2017/12/14/ PY - 2017/11/15/received PY - 2017/12/12/accepted PY - 2017/12/19/pubmed PY - 2018/12/12/medline PY - 2017/12/18/entrez KW - Mitochondria KW - Persulfide KW - Sulfur metabolism KW - Sulfur signaling SP - 77 EP - 90 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 149 N2 - It is now well established that hydrogen sulfide (H2S) is an effector of a wide variety of physiological processes. It is also clear that many of the effects of H2S are mediated through reactions with cysteine sulfur on regulatory proteins and most of these are not mediated directly by H2S but require prior oxidation of H2S and the formation of per- and polysulfides (H2Sn, n = 2-8). Attendant with understanding the regulatory functions of H2S and H2Sn is an appreciation of the mechanisms that control, i.e., both increase and decrease, their production and catabolism. Although a number of standard "conventional" pathways have been described and well characterized, novel "unconventional" pathways are continuously being identified. This review summarizes our current knowledge of both the conventional and unconventional. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/29248597/H2S_and_polysulfide_metabolism:_Conventional_and_unconventional_pathways_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(17)30722-0 DB - PRIME DP - Unbound Medicine ER -