Tags

Type your tag names separated by a space and hit enter

Restricted feeding for 9h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice.
Metabolism. 2018 05; 82:1-13.M

Abstract

BACKGROUND

Obesity is a major public health concern that can result from diets high in fat and sugar, including sugar sweetened beverages. A proposed treatment for dietary-induced obesity is time-restricted feeding (TRF), which restricts consumption of food to specific times of the 24-hour cycle. Although TRF shows great promise to prevent obesity and the development of chronic disease, the effects of TRF to reverse metabolic changes and the development of NAFLD in animal models of a Western diet with sugary water consumption is not known.

OBJECTIVE

The objective of the current study was to evaluate the role of TRF in the treatment of obesity and NAFLD through examination of changes in metabolic and histopathologic parameters.

METHODS

To better understand the role of TRF in the treatment of obesity and NAFLD, we investigated the metabolic phenotype and NAFLD parameters in a mouse model of NAFLD in which obesity and liver steatosis are induced by a Western Diet (WD): a high-fat diet of lard, milkfat and Crisco with sugary drinking water. Mice were subjected to a short-term (4-weeks) and long-term (10-weeks) TRF in which food was restricted to 9h at night.

RESULTS

Prior to TRF treatment, the WD mice had increased body mass, and exhibited less activity, and higher average daytime energy expenditure (EE) than chow fed mice. Approximately 4- and 10-weeks following TFR treatment, WD-TRF had moderate but not statistically significant weight loss compared to WD-ad libitum (WD-AL) mice. There was a modest but significant reduction in the inguinal adipose tissue weight in both WD-TRF groups compared to the WD-AL groups; however, there was no difference in epididymal and retroperitoneal adipose tissue mass or adipocyte size distribution. In contrast, the diet-induced increase in normalized liver tissue weight, hepatic triglyceride, and NAFLD score was partially abrogated in the 4-week WD-TRF mice, while systemic insulin resistance was partially abrogated and glucose intolerance was completely abrogated in the 10-week WD-TRF mice. Importantly, WD-induced metabolic dysfunction (substrate utilization, energy expenditure, and activity) was partially abrogated by 4- and 10-week TRF.

CONCLUSIONS

Our results support the hypothesis that TRF aids in reducing the detrimental metabolic effects of consuming a WD with sugary drinking water but does not ameliorate obesity.

Authors+Show Affiliations

Department of Nutrition, Auburn University, Auburn, AL 36849, USA. Electronic address: lnw0013@auburn.edu.Department of Nutrition, Auburn University, Auburn, AL 36849, USA. Electronic address: yzl0081@auburn.edu.Department of Nutrition, Auburn University, Auburn, AL 36849, USA.Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. Electronic address: ecg0001@auburn.edu.Department of Nutrition, Auburn University, Auburn, AL 36849, USA. Electronic address: bza0017@auburn.edu.Department of Biology, Auburn University Montgomery, Montgomery, AL 36117, USA. Electronic address: aoneill@aum.edu.Department of Nutrition, Auburn University, Auburn, AL 36849, USA; Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL 36849, USA. Electronic address: mwgreene@auburn.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

29253490

Citation

Woodie, Lauren N., et al. "Restricted Feeding for 9h in the Active Period Partially Abrogates the Detrimental Metabolic Effects of a Western Diet With Liquid Sugar Consumption in Mice." Metabolism: Clinical and Experimental, vol. 82, 2018, pp. 1-13.
Woodie LN, Luo Y, Wayne MJ, et al. Restricted feeding for 9h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice. Metabolism. 2018;82:1-13.
Woodie, L. N., Luo, Y., Wayne, M. J., Graff, E. C., Ahmed, B., O'Neill, A. M., & Greene, M. W. (2018). Restricted feeding for 9h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice. Metabolism: Clinical and Experimental, 82, 1-13. https://doi.org/10.1016/j.metabol.2017.12.004
Woodie LN, et al. Restricted Feeding for 9h in the Active Period Partially Abrogates the Detrimental Metabolic Effects of a Western Diet With Liquid Sugar Consumption in Mice. Metabolism. 2018;82:1-13. PubMed PMID: 29253490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Restricted feeding for 9h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice. AU - Woodie,Lauren N, AU - Luo,Yuwen, AU - Wayne,Michael J, AU - Graff,Emily C, AU - Ahmed,Bulbul, AU - O'Neill,Ann Marie, AU - Greene,Michael W, Y1 - 2017/12/16/ PY - 2017/02/14/received PY - 2017/11/16/revised PY - 2017/12/11/accepted PY - 2017/12/19/pubmed PY - 2019/1/1/medline PY - 2017/12/19/entrez KW - Metabolism KW - Non-alcoholic fatty liver disease KW - Obesity KW - Time-restricted feeding KW - Western-diet SP - 1 EP - 13 JF - Metabolism: clinical and experimental JO - Metabolism VL - 82 N2 - BACKGROUND: Obesity is a major public health concern that can result from diets high in fat and sugar, including sugar sweetened beverages. A proposed treatment for dietary-induced obesity is time-restricted feeding (TRF), which restricts consumption of food to specific times of the 24-hour cycle. Although TRF shows great promise to prevent obesity and the development of chronic disease, the effects of TRF to reverse metabolic changes and the development of NAFLD in animal models of a Western diet with sugary water consumption is not known. OBJECTIVE: The objective of the current study was to evaluate the role of TRF in the treatment of obesity and NAFLD through examination of changes in metabolic and histopathologic parameters. METHODS: To better understand the role of TRF in the treatment of obesity and NAFLD, we investigated the metabolic phenotype and NAFLD parameters in a mouse model of NAFLD in which obesity and liver steatosis are induced by a Western Diet (WD): a high-fat diet of lard, milkfat and Crisco with sugary drinking water. Mice were subjected to a short-term (4-weeks) and long-term (10-weeks) TRF in which food was restricted to 9h at night. RESULTS: Prior to TRF treatment, the WD mice had increased body mass, and exhibited less activity, and higher average daytime energy expenditure (EE) than chow fed mice. Approximately 4- and 10-weeks following TFR treatment, WD-TRF had moderate but not statistically significant weight loss compared to WD-ad libitum (WD-AL) mice. There was a modest but significant reduction in the inguinal adipose tissue weight in both WD-TRF groups compared to the WD-AL groups; however, there was no difference in epididymal and retroperitoneal adipose tissue mass or adipocyte size distribution. In contrast, the diet-induced increase in normalized liver tissue weight, hepatic triglyceride, and NAFLD score was partially abrogated in the 4-week WD-TRF mice, while systemic insulin resistance was partially abrogated and glucose intolerance was completely abrogated in the 10-week WD-TRF mice. Importantly, WD-induced metabolic dysfunction (substrate utilization, energy expenditure, and activity) was partially abrogated by 4- and 10-week TRF. CONCLUSIONS: Our results support the hypothesis that TRF aids in reducing the detrimental metabolic effects of consuming a WD with sugary drinking water but does not ameliorate obesity. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/29253490/Restricted_feeding_for_9h_in_the_active_period_partially_abrogates_the_detrimental_metabolic_effects_of_a_Western_diet_with_liquid_sugar_consumption_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(17)30341-4 DB - PRIME DP - Unbound Medicine ER -