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Development of poloxamer gel formulations via hot-melt extrusion technology.
Int J Pharm 2018; 537(1-2):122-131IJ

Abstract

Poloxamer gels are conventionally prepared by the "hot" or the "cold" process. But these techniques have some disadvantages such as high energy consumption, requires expensive equipment and often have scale up issues. Therefore, the objective of this work was to develop poloxamer gels by hot-melt extrusion technology. The model drug selected was ketoprofen. The formulations developed were 30% and 40% poloxamer gels. Of these formulations, the 30% poloxamer gels were selected as ideal gels. DSC and XRD studies showed an amorphous nature of the drug after extrusion. It was observed from the permeation studies that with increasing poloxamer concentration, a decrease in drug permeation was obtained. Other studies conducted for the formulations included in-vitro release studies, texture analysis, rheological studies and pH measurements. In conclusion, the hot-melt extrusion technology could be successfully employed to develop poloxamer gels by overcoming the drawbacks associated with the conventional techniques.

Authors+Show Affiliations

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.Dave C. Swalm School of Chemical Engineering, Mississippi State University, Oktibbeha County, MS 39762, USA.Dave C. Swalm School of Chemical Engineering, Mississippi State University, Oktibbeha County, MS 39762, USA.College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Pii Center for Pharmaceutical Technology, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA. Electronic address: marepka@olemiss.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29253585

Citation

Mendonsa, Nicole S., et al. "Development of Poloxamer Gel Formulations Via Hot-melt Extrusion Technology." International Journal of Pharmaceutics, vol. 537, no. 1-2, 2018, pp. 122-131.
Mendonsa NS, Murthy SN, Hashemnejad SM, et al. Development of poloxamer gel formulations via hot-melt extrusion technology. Int J Pharm. 2018;537(1-2):122-131.
Mendonsa, N. S., Murthy, S. N., Hashemnejad, S. M., Kundu, S., Zhang, F., & Repka, M. A. (2018). Development of poloxamer gel formulations via hot-melt extrusion technology. International Journal of Pharmaceutics, 537(1-2), pp. 122-131. doi:10.1016/j.ijpharm.2017.12.008.
Mendonsa NS, et al. Development of Poloxamer Gel Formulations Via Hot-melt Extrusion Technology. Int J Pharm. 2018 Feb 15;537(1-2):122-131. PubMed PMID: 29253585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of poloxamer gel formulations via hot-melt extrusion technology. AU - Mendonsa,Nicole S, AU - Murthy,S Narasimha, AU - Hashemnejad,Seyed Meysam, AU - Kundu,Santanu, AU - Zhang,Feng, AU - Repka,Michael A, Y1 - 2017/12/16/ PY - 2017/08/21/received PY - 2017/12/02/revised PY - 2017/12/03/accepted PY - 2017/12/19/pubmed PY - 2018/8/7/medline PY - 2017/12/19/entrez KW - Ex-vivo permeation study KW - Hot-melt extrusion KW - In-vitro release study KW - Poloxamer gels KW - Rheology study SP - 122 EP - 131 JF - International journal of pharmaceutics JO - Int J Pharm VL - 537 IS - 1-2 N2 - Poloxamer gels are conventionally prepared by the "hot" or the "cold" process. But these techniques have some disadvantages such as high energy consumption, requires expensive equipment and often have scale up issues. Therefore, the objective of this work was to develop poloxamer gels by hot-melt extrusion technology. The model drug selected was ketoprofen. The formulations developed were 30% and 40% poloxamer gels. Of these formulations, the 30% poloxamer gels were selected as ideal gels. DSC and XRD studies showed an amorphous nature of the drug after extrusion. It was observed from the permeation studies that with increasing poloxamer concentration, a decrease in drug permeation was obtained. Other studies conducted for the formulations included in-vitro release studies, texture analysis, rheological studies and pH measurements. In conclusion, the hot-melt extrusion technology could be successfully employed to develop poloxamer gels by overcoming the drawbacks associated with the conventional techniques. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/29253585/Development_of_poloxamer_gel_formulations_via_hot_melt_extrusion_technology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(17)31135-3 DB - PRIME DP - Unbound Medicine ER -