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Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes with Permanent Temporal Hemianopia from Chiasmal Compression.
Front Neurol. 2017; 8:619.FN

Abstract

PURPOSE

The aims of this study are to compare optical coherence tomography (OCT)-measured macular retinal layers in eyes with permanent temporal hemianopia from chiasmal compression and control eyes; to compare regular and slow-flash multifocal electroretinography (mfERG) in patients and controls; and to assess the correlation between OCT, mfERG, and central visual field (SAP) data.

METHODS

Forty-three eyes of 30 patients with permanent temporal hemianopia due to pituitary tumors who were previously submitted to chiasm decompression and 37 healthy eyes of 19 controls were submitted to macular spectral domain OCT, mfERG, and 10-2 SAP testing. After segmentation, the thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer, and photoreceptor layer (PRL) was measured. Amplitudes and oscillatory potentials (OPs) were measured on regular and slow-flash mfERG, respectively, and expressed as the mean values per quadrant and hemifield.

RESULTS

RNFL, GCL, and IPL thickness measurements were significantly reduced in all quadrants, whereas INL, OPL, and PRL thicknesses were significantly increased in the nasal quadrants in patients compared to those in controls. Significant correlations between OCT and 10-2 SAP measurements were positive for the RNFL, GCL, and IPL and negative for the INL, OPL, and PRL. OPs and mfERG N1 amplitudes were significantly reduced in the nasal hemiretina of patients. Significant correlations were found between OP and mfERG amplitudes for inner and outer nasal hemiretina OCT measurements, respectively.

CONCLUSION

Patients with permanent temporal hemianopia from previously treated chiasmal compression demonstrated significant thinning of the RNFL, GCL, IPL, and thickening of the INL, OPL, and PRL associated with reduced OP and mfERG N1 amplitudes, suggesting that axonal injury to the inner retina leads to secondary damage to the outer retina in this condition.

Authors+Show Affiliations

Laboratory of Investigation in Ophthalmology (LIM 33), Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Laboratory of Investigation in Ophthalmology (LIM 33), Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Laboratory of Investigation in Ophthalmology (LIM 33), Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Department of Ophtalmology, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.Laboratory of Investigation in Ophthalmology (LIM 33), Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Laboratory of Investigation in Ophthalmology (LIM 33), Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29255441

Citation

de Araújo, Rafael B., et al. "Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes With Permanent Temporal Hemianopia From Chiasmal Compression." Frontiers in Neurology, vol. 8, 2017, p. 619.
de Araújo RB, Oyamada MK, Zacharias LC, et al. Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes with Permanent Temporal Hemianopia from Chiasmal Compression. Front Neurol. 2017;8:619.
de Araújo, R. B., Oyamada, M. K., Zacharias, L. C., Cunha, L. P., Preti, R. C., & Monteiro, M. L. R. (2017). Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes with Permanent Temporal Hemianopia from Chiasmal Compression. Frontiers in Neurology, 8, 619. https://doi.org/10.3389/fneur.2017.00619
de Araújo RB, et al. Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes With Permanent Temporal Hemianopia From Chiasmal Compression. Front Neurol. 2017;8:619. PubMed PMID: 29255441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes with Permanent Temporal Hemianopia from Chiasmal Compression. AU - de Araújo,Rafael B, AU - Oyamada,Maria K, AU - Zacharias,Leandro C, AU - Cunha,Leonardo P, AU - Preti,Rony C, AU - Monteiro,Mário L R, Y1 - 2017/12/04/ PY - 2017/09/25/received PY - 2017/11/06/accepted PY - 2017/12/20/entrez PY - 2017/12/20/pubmed PY - 2017/12/20/medline KW - chiasmal compression KW - multifocal electroretinography KW - optical coherence tomography KW - oscillatory potentials KW - standard automated perimetry KW - temporal hemianopia SP - 619 EP - 619 JF - Frontiers in neurology JO - Front Neurol VL - 8 N2 - PURPOSE: The aims of this study are to compare optical coherence tomography (OCT)-measured macular retinal layers in eyes with permanent temporal hemianopia from chiasmal compression and control eyes; to compare regular and slow-flash multifocal electroretinography (mfERG) in patients and controls; and to assess the correlation between OCT, mfERG, and central visual field (SAP) data. METHODS: Forty-three eyes of 30 patients with permanent temporal hemianopia due to pituitary tumors who were previously submitted to chiasm decompression and 37 healthy eyes of 19 controls were submitted to macular spectral domain OCT, mfERG, and 10-2 SAP testing. After segmentation, the thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer, and photoreceptor layer (PRL) was measured. Amplitudes and oscillatory potentials (OPs) were measured on regular and slow-flash mfERG, respectively, and expressed as the mean values per quadrant and hemifield. RESULTS: RNFL, GCL, and IPL thickness measurements were significantly reduced in all quadrants, whereas INL, OPL, and PRL thicknesses were significantly increased in the nasal quadrants in patients compared to those in controls. Significant correlations between OCT and 10-2 SAP measurements were positive for the RNFL, GCL, and IPL and negative for the INL, OPL, and PRL. OPs and mfERG N1 amplitudes were significantly reduced in the nasal hemiretina of patients. Significant correlations were found between OP and mfERG amplitudes for inner and outer nasal hemiretina OCT measurements, respectively. CONCLUSION: Patients with permanent temporal hemianopia from previously treated chiasmal compression demonstrated significant thinning of the RNFL, GCL, IPL, and thickening of the INL, OPL, and PRL associated with reduced OP and mfERG N1 amplitudes, suggesting that axonal injury to the inner retina leads to secondary damage to the outer retina in this condition. SN - 1664-2295 UR - https://www.unboundmedicine.com/medline/citation/29255441/Morphological_and_Functional_Inner_and_Outer_Retinal_Layer_Abnormalities_in_Eyes_with_Permanent_Temporal_Hemianopia_from_Chiasmal_Compression_ DB - PRIME DP - Unbound Medicine ER -
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