Tags

Type your tag names separated by a space and hit enter

Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial.
Clin Nutr. 2018 12; 37(6 Pt A):1871-1878.CN

Abstract

BACKGROUND & AIMS

Indirect comparisons suggest that alternate-day fasting (ADF) may produce greater improvements in body composition, fat distribution, and/or the adipokine profile compared to daily calorie restriction (CR), but this has not been tested directly. In a pre-planned secondary analysis of a randomized controlled trial, we compared changes in the VAT:SAT ratio, FFM:total mass ratio, and the adipokine profile between ADF and CR.

METHODS

Overweight and obese participants (n = 100) were randomized to 1) ADF (alternating every 24-h between consuming 25% or 125% of energy needs); 2) CR (consuming 75% of needs every day); or 3) control (consuming 100% of needs every day) for 24 wk.

RESULTS

The VAT:SAT ratio did not change in any group. The FFM:total mass ratio increased in both ADF (0.03 ± 0.00) and CR (0.03 ± 0.01) compared to the control group (P < 0.01), with no differences between the intervention groups. Circulating leptin decreased in both the ADF group (-18 ± 6%) and CR group (-31 ± 10%) relative to the control group (P < 0.05), with no differences between the intervention groups. Circulating levels of adiponectin, resistin, IL-6, and TNF-α did not change in either intervention group relative to the control group.

CONCLUSION

ADF and CR similarly improve the FFM:total mass ratio and reduce leptin after a 24-wk intervention.

TRIAL REGISTRATION

Clinicaltrials.gov, number NCT00960505.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA; Stanford Prevention Research Center, Stanford University, Stanford, CA, USA. Electronic address: jtrepa2@stanford.edu.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA; Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.Nutrition and Obesity Division, Pennington Biomedical Research Center, Baton Rouge, LA, USA.Nutrition and Obesity Division, Pennington Biomedical Research Center, Baton Rouge, LA, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29258678

Citation

Trepanowski, John F., et al. "Effects of Alternate-day Fasting or Daily Calorie Restriction On Body Composition, Fat Distribution, and Circulating Adipokines: Secondary Analysis of a Randomized Controlled Trial." Clinical Nutrition (Edinburgh, Scotland), vol. 37, no. 6 Pt A, 2018, pp. 1871-1878.
Trepanowski JF, Kroeger CM, Barnosky A, et al. Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clin Nutr. 2018;37(6 Pt A):1871-1878.
Trepanowski, J. F., Kroeger, C. M., Barnosky, A., Klempel, M., Bhutani, S., Hoddy, K. K., Rood, J., Ravussin, E., & Varady, K. A. (2018). Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clinical Nutrition (Edinburgh, Scotland), 37(6 Pt A), 1871-1878. https://doi.org/10.1016/j.clnu.2017.11.018
Trepanowski JF, et al. Effects of Alternate-day Fasting or Daily Calorie Restriction On Body Composition, Fat Distribution, and Circulating Adipokines: Secondary Analysis of a Randomized Controlled Trial. Clin Nutr. 2018;37(6 Pt A):1871-1878. PubMed PMID: 29258678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. AU - Trepanowski,John F, AU - Kroeger,Cynthia M, AU - Barnosky,Adrienne, AU - Klempel,Monica, AU - Bhutani,Surabhi, AU - Hoddy,Kristin K, AU - Rood,Jennifer, AU - Ravussin,Eric, AU - Varady,Krista A, Y1 - 2017/12/05/ PY - 2017/08/02/received PY - 2017/11/16/revised PY - 2017/11/20/accepted PY - 2017/12/21/pubmed PY - 2019/12/4/medline PY - 2017/12/21/entrez KW - Adipokine KW - Alternate day fasting KW - Body composition KW - Calorie restriction KW - Obese adult KW - Visceral adipose tissue SP - 1871 EP - 1878 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 37 IS - 6 Pt A N2 - BACKGROUND & AIMS: Indirect comparisons suggest that alternate-day fasting (ADF) may produce greater improvements in body composition, fat distribution, and/or the adipokine profile compared to daily calorie restriction (CR), but this has not been tested directly. In a pre-planned secondary analysis of a randomized controlled trial, we compared changes in the VAT:SAT ratio, FFM:total mass ratio, and the adipokine profile between ADF and CR. METHODS: Overweight and obese participants (n = 100) were randomized to 1) ADF (alternating every 24-h between consuming 25% or 125% of energy needs); 2) CR (consuming 75% of needs every day); or 3) control (consuming 100% of needs every day) for 24 wk. RESULTS: The VAT:SAT ratio did not change in any group. The FFM:total mass ratio increased in both ADF (0.03 ± 0.00) and CR (0.03 ± 0.01) compared to the control group (P < 0.01), with no differences between the intervention groups. Circulating leptin decreased in both the ADF group (-18 ± 6%) and CR group (-31 ± 10%) relative to the control group (P < 0.05), with no differences between the intervention groups. Circulating levels of adiponectin, resistin, IL-6, and TNF-α did not change in either intervention group relative to the control group. CONCLUSION: ADF and CR similarly improve the FFM:total mass ratio and reduce leptin after a 24-wk intervention. TRIAL REGISTRATION: Clinicaltrials.gov, number NCT00960505. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/29258678/Effects_of_alternate_day_fasting_or_daily_calorie_restriction_on_body_composition_fat_distribution_and_circulating_adipokines:_Secondary_analysis_of_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(17)31416-4 DB - PRIME DP - Unbound Medicine ER -