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Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes.
Br J Ophthalmol. 2018 09; 102(9):1226-1231.BJ

Abstract

AIM

To evaluate the correlation between inner retinal layer thinning and the foveal microvasculature in type 2 diabetes using optical coherence tomography angiography (OCTA).

METHODS

A cross-sectional study involved 155 diabetic eyes. All patients were divided into two groups based on diabetic retinopathy (DR) grade: no DR (NDR, n=80) and mild-to-moderate non-proliferative DR (NPDR, n=75). Foveal avascular zone (FAZ) area, FAZ circularity index, FAZ perimeter, vessel density and perfusion index of parafoveal and perifoveal area were calculated using OCTA. The thickness of the macular ganglion cell/inner plexiform layer (mGCIPL) was measured using OCT.

RESULTS

In both superficial and deep retinal capillary layers (SRL and DRL), FAZ areas in the NDR (0.38 mm2 , 0.49 mm2) and NPDR (0.38 mm2, 0.48 mm2) were greater than those in the control (0.33 mm2, 0.43 mm2). The FAZ circularity index, vessel density and perfusion index in the NDR (0.63, 17.8/mm, 0.32) and NPDR (0.63, 17.5/mm, 0.32) were smaller than those in the control (0.69, 19.6/mm, 0.39). mGCIPL thickness was significantly correlated with FAZ area in the SRL and DRL, as well as with FAZ circularity index, vessel density and perfusion index in the NDR and NPDR. In multivariate regression analysis, the FAZ circularity index (OR=12.2) and vessel density of the parafovea (OR=1.95) were correlated with mGCIPL thinning.

CONCLUSION

OCTA revealed that early foveal microcirculatory alterations in diabetic eyes were related to mGCIPL thickness, regardless of the presence of DR. The decrease in FAZ circularity and parafoveal vessel density were highly correlated with mGCIPL thinning.

Authors+Show Affiliations

Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea.Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea.Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29259019

Citation

Kim, Kiyoung, et al. "Optical Coherence Tomography Angiography Analysis of Foveal Microvascular Changes and Inner Retinal Layer Thinning in Patients With Diabetes." The British Journal of Ophthalmology, vol. 102, no. 9, 2018, pp. 1226-1231.
Kim K, Kim ES, Yu SY. Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes. Br J Ophthalmol. 2018;102(9):1226-1231.
Kim, K., Kim, E. S., & Yu, S. Y. (2018). Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes. The British Journal of Ophthalmology, 102(9), 1226-1231. https://doi.org/10.1136/bjophthalmol-2017-311149
Kim K, Kim ES, Yu SY. Optical Coherence Tomography Angiography Analysis of Foveal Microvascular Changes and Inner Retinal Layer Thinning in Patients With Diabetes. Br J Ophthalmol. 2018;102(9):1226-1231. PubMed PMID: 29259019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes. AU - Kim,Kiyoung, AU - Kim,Eung Suk, AU - Yu,Seung-Young, Y1 - 2017/12/19/ PY - 2017/08/07/received PY - 2017/11/25/revised PY - 2017/12/04/accepted PY - 2017/12/21/pubmed PY - 2019/3/29/medline PY - 2017/12/21/entrez KW - diagnostic tests/investigation KW - imaging KW - macula KW - retina SP - 1226 EP - 1231 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 102 IS - 9 N2 - AIM: To evaluate the correlation between inner retinal layer thinning and the foveal microvasculature in type 2 diabetes using optical coherence tomography angiography (OCTA). METHODS: A cross-sectional study involved 155 diabetic eyes. All patients were divided into two groups based on diabetic retinopathy (DR) grade: no DR (NDR, n=80) and mild-to-moderate non-proliferative DR (NPDR, n=75). Foveal avascular zone (FAZ) area, FAZ circularity index, FAZ perimeter, vessel density and perfusion index of parafoveal and perifoveal area were calculated using OCTA. The thickness of the macular ganglion cell/inner plexiform layer (mGCIPL) was measured using OCT. RESULTS: In both superficial and deep retinal capillary layers (SRL and DRL), FAZ areas in the NDR (0.38 mm2 , 0.49 mm2) and NPDR (0.38 mm2, 0.48 mm2) were greater than those in the control (0.33 mm2, 0.43 mm2). The FAZ circularity index, vessel density and perfusion index in the NDR (0.63, 17.8/mm, 0.32) and NPDR (0.63, 17.5/mm, 0.32) were smaller than those in the control (0.69, 19.6/mm, 0.39). mGCIPL thickness was significantly correlated with FAZ area in the SRL and DRL, as well as with FAZ circularity index, vessel density and perfusion index in the NDR and NPDR. In multivariate regression analysis, the FAZ circularity index (OR=12.2) and vessel density of the parafovea (OR=1.95) were correlated with mGCIPL thinning. CONCLUSION: OCTA revealed that early foveal microcirculatory alterations in diabetic eyes were related to mGCIPL thickness, regardless of the presence of DR. The decrease in FAZ circularity and parafoveal vessel density were highly correlated with mGCIPL thinning. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/29259019/Optical_coherence_tomography_angiography_analysis_of_foveal_microvascular_changes_and_inner_retinal_layer_thinning_in_patients_with_diabetes_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=29259019 DB - PRIME DP - Unbound Medicine ER -