Tags

Type your tag names separated by a space and hit enter

Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas.
Clin Ophthalmol 2017; 11:2177-2181CO

Abstract

Aim

To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma.

Patients and Methods

This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Treatment response was evaluated according to the size of the tumor (horizontal diameter); additionally, complications of both treatment methods were recorded.

Results

This study included 33 infants: 21 females (64%) and 12 males (36%). The mean age at the time of injection was 4.9±2.6 months. The study included three modes of treatment response: regression of the tumor, 28 patients (85%); stabilization, three patients (9%); and failure, two patients (6%), which necessitated repeated intralesional injection of triamcinolone but with minimal response. Regarding complications, only one patient reported with subconjunctival hemorrhage during intralesional injection of steroids; there were no recorded cases of hypotension, bradycardia, or hypoglycemia during the course of oral propranolol treatment. After the end of the follow-up period, there were no reported cases of recurrent increase in the size of the regressed group of infantile hemangiomas with stable tumor size.

Conclusion

Combined oral propranolol with intralesional injection of triamcinolone acetonide is the effective method of treatment for infantile periorbital capillary hemangioma with minimal adverse effects.

Authors+Show Affiliations

Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29263646

Citation

Alsmman, Alahmady H., and Amr Mounir. "Combined Oral Propranolol With Intralesional Injection of Triamcinolone Acetonide in Treatment of Infantile Periocular Hemangiomas." Clinical Ophthalmology (Auckland, N.Z.), vol. 11, 2017, pp. 2177-2181.
Alsmman AH, Mounir A. Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas. Clin Ophthalmol. 2017;11:2177-2181.
Alsmman, A. H., & Mounir, A. (2017). Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas. Clinical Ophthalmology (Auckland, N.Z.), 11, pp. 2177-2181. doi:10.2147/OPTH.S153121.
Alsmman AH, Mounir A. Combined Oral Propranolol With Intralesional Injection of Triamcinolone Acetonide in Treatment of Infantile Periocular Hemangiomas. Clin Ophthalmol. 2017;11:2177-2181. PubMed PMID: 29263646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas. AU - Alsmman,Alahmady H, AU - Mounir,Amr, Y1 - 2017/12/08/ PY - 2017/12/22/entrez PY - 2017/12/22/pubmed PY - 2017/12/22/medline KW - infantile periocular hemangioma KW - intralesional injection KW - oral propranolol KW - triamcinolone acetonide SP - 2177 EP - 2181 JF - Clinical ophthalmology (Auckland, N.Z.) JO - Clin Ophthalmol VL - 11 N2 - Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma. Patients and Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Treatment response was evaluated according to the size of the tumor (horizontal diameter); additionally, complications of both treatment methods were recorded. Results: This study included 33 infants: 21 females (64%) and 12 males (36%). The mean age at the time of injection was 4.9±2.6 months. The study included three modes of treatment response: regression of the tumor, 28 patients (85%); stabilization, three patients (9%); and failure, two patients (6%), which necessitated repeated intralesional injection of triamcinolone but with minimal response. Regarding complications, only one patient reported with subconjunctival hemorrhage during intralesional injection of steroids; there were no recorded cases of hypotension, bradycardia, or hypoglycemia during the course of oral propranolol treatment. After the end of the follow-up period, there were no reported cases of recurrent increase in the size of the regressed group of infantile hemangiomas with stable tumor size. Conclusion: Combined oral propranolol with intralesional injection of triamcinolone acetonide is the effective method of treatment for infantile periorbital capillary hemangioma with minimal adverse effects. SN - 1177-5467 UR - https://www.unboundmedicine.com/medline/citation/29263646/Combined_oral_propranolol_with_intralesional_injection_of_triamcinolone_acetonide_in_treatment_of_infantile_periocular_hemangiomas_ L2 - https://dx.doi.org/10.2147/OPTH.S153121 DB - PRIME DP - Unbound Medicine ER -