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Diagnosis and treatment of macrocytic anemias in adults.
J Gen Fam Med 2017; 18(5):200-204JG

Abstract

Anemia is one of the most common health problems in the primary care setting. Macrocytosis in adults is defined as a red blood cell (RBC) mean corpuscular volume (MCV) >100 femtoliter (fL). Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia. Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folate, whereas nonmegaloblastic macrocytic anemia is caused by various diseases such as myelodysplastic syndrome (MDS), liver dysfunction, alcoholism, hypothyroidism, certain drugs, and by less commonly inherited disorders of DNA synthesis. Macrocytic anemias are treated with cause-specific therapies, and it is crucial to differentiate nonmegaloblastic from megaloblastic anemia. Because MDS and myeloid neoplasms commonly affect the elderly, primary care physicians may encounter more cases of macrocytic anemias in the near future, as the older population increases. When MDS is suspected along with leukocytopenia and/or thrombocytopenia with anemia, a hematology consultation may be appropriate.

Authors+Show Affiliations

Department of General Internal Medicine and Clinical Laboratory Medicine Akita University Graduate School of Medicine Akita Japan.Department of General Internal Medicine and Clinical Laboratory Medicine Akita University Graduate School of Medicine Akita Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29264027

Citation

Nagao, Takayo, and Makoto Hirokawa. "Diagnosis and Treatment of Macrocytic Anemias in Adults." Journal of General and Family Medicine, vol. 18, no. 5, 2017, pp. 200-204.
Nagao T, Hirokawa M. Diagnosis and treatment of macrocytic anemias in adults. J Gen Fam Med. 2017;18(5):200-204.
Nagao, T., & Hirokawa, M. (2017). Diagnosis and treatment of macrocytic anemias in adults. Journal of General and Family Medicine, 18(5), pp. 200-204. doi:10.1002/jgf2.31.
Nagao T, Hirokawa M. Diagnosis and Treatment of Macrocytic Anemias in Adults. J Gen Fam Med. 2017;18(5):200-204. PubMed PMID: 29264027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and treatment of macrocytic anemias in adults. AU - Nagao,Takayo, AU - Hirokawa,Makoto, Y1 - 2017/04/13/ PY - 2016/03/08/received PY - 2016/05/25/accepted PY - 2017/12/22/entrez PY - 2017/12/22/pubmed PY - 2017/12/22/medline KW - macrocytic anemias KW - megaloblastic KW - myelodysplastic syndrome KW - nonmegaloblastic KW - pernicious anemia SP - 200 EP - 204 JF - Journal of general and family medicine JO - J Gen Fam Med VL - 18 IS - 5 N2 - Anemia is one of the most common health problems in the primary care setting. Macrocytosis in adults is defined as a red blood cell (RBC) mean corpuscular volume (MCV) >100 femtoliter (fL). Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia. Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folate, whereas nonmegaloblastic macrocytic anemia is caused by various diseases such as myelodysplastic syndrome (MDS), liver dysfunction, alcoholism, hypothyroidism, certain drugs, and by less commonly inherited disorders of DNA synthesis. Macrocytic anemias are treated with cause-specific therapies, and it is crucial to differentiate nonmegaloblastic from megaloblastic anemia. Because MDS and myeloid neoplasms commonly affect the elderly, primary care physicians may encounter more cases of macrocytic anemias in the near future, as the older population increases. When MDS is suspected along with leukocytopenia and/or thrombocytopenia with anemia, a hematology consultation may be appropriate. SN - 2189-6577 UR - https://www.unboundmedicine.com/medline/citation/29264027/Diagnosis_and_treatment_of_macrocytic_anemias_in_adults_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29264027/ DB - PRIME DP - Unbound Medicine ER -