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Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia).
Toxins (Basel). 2017 12 21; 10(1)T

Abstract

Ciguatera fish poisoning (CFP) is a foodborne disease caused by the consumption of seafood (fish and marine invertebrates) contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the genus Gambierdiscus. The report of a CFP-like mass-poisoning outbreak following the consumption of Tectus niloticus (Tegulidae, Gastropod) from Anaho Bay on Nuku Hiva Island (Marquesas archipelago, French Polynesia) prompted field investigations to assess the presence of CTXs in T. niloticus. Samples were collected from Anaho Bay, 1, 6 and 28 months after this poisoning outbreak, as well as in Taiohae and Taipivai bays. Toxicity analysis using the neuroblastoma cell-based assay (CBA-N2a) detected the presence of CTXs only in Anaho Bay T. niloticus samples. This is consistent with qPCR results on window screen samples indicating the presence of Gambierdiscus communities dominated by the species G. polynesiensis in Anaho Bay. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses revealed that P-CTX-3B was the major congener, followed by P-CTX-3C, P-CTX-4A and P-CTX-4B in toxic samples. Between July 2014 and November 2016, toxin content in T. niloticus progressively decreased, but was consistently above the safety limit recommended for human consumption. This study confirms for the first time T. niloticus as a novel vector of CFP in French Polynesia.

Authors+Show Affiliations

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia. tdarius@ilm.pf.Institut de Recherche pour le Développement (IRD)-UMR 241-EIO, P.O. Box 529, 98713 Papeete, Tahiti, French Polynesia. melanie.roue@ird.fr.IFREMER, Phycotoxins Laboratory, F-44311 Nantes, France. manoella.sibat@ifremer.fr.Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia. jviallon@ilm.pf.Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia.National Oceanic and Atmospheric Administration, National Ocean Service, Centers for Coastal Ocean Science, Beaufort Laboratory, Beaufort, NC 28516, USA. mark.w.vandersea@noaa.gov.Ocean Tester, LLC, Beaufort, NC 28516, USA. ocean.tester@gmail.com.National Oceanic and Atmospheric Administration, National Ocean Service, Centers for Coastal Ocean Science, Beaufort Laboratory, Beaufort, NC 28516, USA. wayne.litaker@noaa.gov.IFREMER, Phycotoxins Laboratory, F-44311 Nantes, France. zouher.amzil@ifremer.fr.IFREMER, Phycotoxins Laboratory, F-44311 Nantes, France. philipp.hess@ifremer.fr.Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia. mchinain@ilm.pf.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29267222

Citation

Darius, Hélène Taiana, et al. "Tectus Niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples From Nuku Hiva Island (French Polynesia)." Toxins, vol. 10, no. 1, 2017.
Darius HT, Roué M, Sibat M, et al. Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia). Toxins (Basel). 2017;10(1).
Darius, H. T., Roué, M., Sibat, M., Viallon, J., Gatti, C. M. I., Vandersea, M. W., Tester, P. A., Litaker, R. W., Amzil, Z., Hess, P., & Chinain, M. (2017). Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia). Toxins, 10(1). https://doi.org/10.3390/toxins10010002
Darius HT, et al. Tectus Niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples From Nuku Hiva Island (French Polynesia). Toxins (Basel). 2017 12 21;10(1) PubMed PMID: 29267222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia). AU - Darius,Hélène Taiana, AU - Roué,Mélanie, AU - Sibat,Manoella, AU - Viallon,Jérôme, AU - Gatti,Clémence Mahana Iti, AU - Vandersea,Mark W, AU - Tester,Patricia A, AU - Litaker,R Wayne, AU - Amzil,Zouher, AU - Hess,Philipp, AU - Chinain,Mireille, Y1 - 2017/12/21/ PY - 2017/11/25/received PY - 2017/12/15/revised PY - 2017/12/18/accepted PY - 2017/12/22/entrez PY - 2017/12/22/pubmed PY - 2018/12/24/medline KW - CBA-N2a KW - Gambierdiscus polynesiensis KW - LC-MS/MS KW - Tectus niloticus KW - ciguatera poisoning KW - ciguatoxins KW - gastropods KW - qPCR assays JF - Toxins JO - Toxins (Basel) VL - 10 IS - 1 N2 - Ciguatera fish poisoning (CFP) is a foodborne disease caused by the consumption of seafood (fish and marine invertebrates) contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the genus Gambierdiscus. The report of a CFP-like mass-poisoning outbreak following the consumption of Tectus niloticus (Tegulidae, Gastropod) from Anaho Bay on Nuku Hiva Island (Marquesas archipelago, French Polynesia) prompted field investigations to assess the presence of CTXs in T. niloticus. Samples were collected from Anaho Bay, 1, 6 and 28 months after this poisoning outbreak, as well as in Taiohae and Taipivai bays. Toxicity analysis using the neuroblastoma cell-based assay (CBA-N2a) detected the presence of CTXs only in Anaho Bay T. niloticus samples. This is consistent with qPCR results on window screen samples indicating the presence of Gambierdiscus communities dominated by the species G. polynesiensis in Anaho Bay. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses revealed that P-CTX-3B was the major congener, followed by P-CTX-3C, P-CTX-4A and P-CTX-4B in toxic samples. Between July 2014 and November 2016, toxin content in T. niloticus progressively decreased, but was consistently above the safety limit recommended for human consumption. This study confirms for the first time T. niloticus as a novel vector of CFP in French Polynesia. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/29267222/Tectus_niloticus__Tegulidae_Gastropod__as_a_Novel_Vector_of_Ciguatera_Poisoning:_Detection_of_Pacific_Ciguatoxins_in_Toxic_Samples_from_Nuku_Hiva_Island__French_Polynesia__ L2 - https://www.mdpi.com/resolver?pii=toxins10010002 DB - PRIME DP - Unbound Medicine ER -