Tags

Type your tag names separated by a space and hit enter

Literature Evidence and ARRIVE Assessment on Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models.
CNS Neurol Disord Drug Targets. 2018 04 26; 17(1):34-42.CN

Abstract

BACKGROUND AND OBJECTIVE

This paper was based on a literature search of PubMed and Scielo databases using the keywords "Flavonoids, Neuroprotection, Quercetin, Rutin, Isoquercitrin, Alzheimer, Parkinson, Huntington" and combinations of all the words.

METHOD

We collected relevant publications, during the period of 2000 to 2016, emphasizing in vivo and in vitro studies with neurological assessment of flavonol's potentials, as well as classifying studies according to evidence levels, in order to elucidate evidence-based literature and its application on clinical research. In addition, we highlight the importance of flavonols in modern research fields, indicating their neuroprotective potential and use thereof as preventive and therapeutic treatment of numerous neurodegenerative disease. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, represent worldwide a major health problem with great financial impact. They are multifactorial diseases, hallmarked by similar pathogenesis that covers conditions such as oxidative stress, formation of free radicals, abnormal protein dynamics (degradation and aggregation), mitochondrial dysfunction, lipid peroxidation and cellular death or senescence. Flavonols are polyphenolic compounds, widely distributed in the plant kingdom and found in high concentrations in vegetables, fruits and teas. Their neuroprotective effects are mainly related to their antioxidant, anti-proliferative and anti-inflammatory properties.

CONCLUSION

It was this paper's intention to contribute with an evidence analysis of recent studies approaching neuroprotective effects of flavonols and the potential to conduct human clinical studies.

Authors+Show Affiliations

Scientific Initiation Program, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.Scientific Initiation Program, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.Scientific Initiation Program, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.Postgraduated Program in Health, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.Postgraduated Program in Health, Sao Francisco University Medical School, Braganca Paulista, Sao Paulo, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29268692

Citation

Bombardi Duarte, Ana Carolina, et al. "Literature Evidence and ARRIVE Assessment On Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models." CNS & Neurological Disorders Drug Targets, vol. 17, no. 1, 2018, pp. 34-42.
Bombardi Duarte AC, Santana MG, di Camilo Orfali G, et al. Literature Evidence and ARRIVE Assessment on Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models. CNS Neurol Disord Drug Targets. 2018;17(1):34-42.
Bombardi Duarte, A. C., Santana, M. G., di Camilo Orfali, G., de Oliveira, C. T. P., & Priolli, D. G. (2018). Literature Evidence and ARRIVE Assessment on Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models. CNS & Neurological Disorders Drug Targets, 17(1), 34-42. https://doi.org/10.2174/1871527317666171221110139
Bombardi Duarte AC, et al. Literature Evidence and ARRIVE Assessment On Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models. CNS Neurol Disord Drug Targets. 2018 04 26;17(1):34-42. PubMed PMID: 29268692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Literature Evidence and ARRIVE Assessment on Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models. AU - Bombardi Duarte,Ana Carolina, AU - Santana,Maycon Giovani, AU - di Camilo Orfali,Guilherme, AU - de Oliveira,Carlos Tadeu Parisi, AU - Priolli,Denise Goncalves, PY - 2017/03/03/received PY - 2017/07/11/revised PY - 2017/12/14/accepted PY - 2017/12/23/pubmed PY - 2019/6/1/medline PY - 2017/12/23/entrez KW - Alzheimer KW - Parkinson KW - animal models KW - flavonoids KW - huntington KW - neurodegenerative. SP - 34 EP - 42 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 17 IS - 1 N2 - BACKGROUND AND OBJECTIVE: This paper was based on a literature search of PubMed and Scielo databases using the keywords "Flavonoids, Neuroprotection, Quercetin, Rutin, Isoquercitrin, Alzheimer, Parkinson, Huntington" and combinations of all the words. METHOD: We collected relevant publications, during the period of 2000 to 2016, emphasizing in vivo and in vitro studies with neurological assessment of flavonol's potentials, as well as classifying studies according to evidence levels, in order to elucidate evidence-based literature and its application on clinical research. In addition, we highlight the importance of flavonols in modern research fields, indicating their neuroprotective potential and use thereof as preventive and therapeutic treatment of numerous neurodegenerative disease. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, represent worldwide a major health problem with great financial impact. They are multifactorial diseases, hallmarked by similar pathogenesis that covers conditions such as oxidative stress, formation of free radicals, abnormal protein dynamics (degradation and aggregation), mitochondrial dysfunction, lipid peroxidation and cellular death or senescence. Flavonols are polyphenolic compounds, widely distributed in the plant kingdom and found in high concentrations in vegetables, fruits and teas. Their neuroprotective effects are mainly related to their antioxidant, anti-proliferative and anti-inflammatory properties. CONCLUSION: It was this paper's intention to contribute with an evidence analysis of recent studies approaching neuroprotective effects of flavonols and the potential to conduct human clinical studies. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/29268692/Literature_Evidence_and_ARRIVE_Assessment_on_Neuroprotective_Effects_of_Flavonols_in_Neurodegenerative_Diseases'_Models_ L2 - http://www.eurekaselect.com/158499/article DB - PRIME DP - Unbound Medicine ER -