Tags

Type your tag names separated by a space and hit enter

Clinical Perspectives of Lithium's Neuroprotective Effect.
Pharmacopsychiatry. 2018 Sep; 51(5):194-199.P

Abstract

Evidence for a neuroprotective effect of lithium has accumulated over the last 2 decades, and this phenomenon has been regarded as an important mechanism of lithium action in mood disorders. It has been reflected by an increase in cerebral gray matter volume in lithium-treated subjects and by the favorable influence of lithium on cognitive functions. A neuroprotective effect of lithium also makes this ion a possible candidate for use as a therapeutic drug in neurology, especially in neurodegenerative disorders. In this paper, neurochemical mechanisms of neuroprotective action of lithium will be characterized. A possible association between the effect of lithium on brain structures reflected in neuroimaging studies, as well as on cognitive functions, and its neuroprotective action, will be considered. Data from experimental, epidemiological, and clinical studies have also pointed to an antidementia effect of lithium, bringing about some promise of using lithium in the treatment of mild cognitive impairment and Alzheimer's disease. The results of attempts of employing lithium in other neurodegenerative disorders will also be discussed.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Rybakowski JK
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Suwalska A
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Hajek T
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. National Institute of Mental Health, Klecany, Czech Republic.

MeSH

Brain DiseasesHumansLithium CompoundsNeuroprotective Agents

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29270949

Citation

Rybakowski, Janusz K., et al. "Clinical Perspectives of Lithium's Neuroprotective Effect." Pharmacopsychiatry, vol. 51, no. 5, 2018, pp. 194-199.
Rybakowski JK, Suwalska A, Hajek T. Clinical Perspectives of Lithium's Neuroprotective Effect. Pharmacopsychiatry. 2018;51(5):194-199.
Rybakowski, J. K., Suwalska, A., & Hajek, T. (2018). Clinical Perspectives of Lithium's Neuroprotective Effect. Pharmacopsychiatry, 51(5), 194-199. https://doi.org/10.1055/s-0043-124436
Rybakowski JK, Suwalska A, Hajek T. Clinical Perspectives of Lithium's Neuroprotective Effect. Pharmacopsychiatry. 2018;51(5):194-199. PubMed PMID: 29270949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Perspectives of Lithium's Neuroprotective Effect. AU - Rybakowski,Janusz K, AU - Suwalska,Aleksandra, AU - Hajek,Tomas, Y1 - 2017/12/21/ PY - 2017/12/23/pubmed PY - 2018/11/20/medline PY - 2017/12/23/entrez SP - 194 EP - 199 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 51 IS - 5 N2 - Evidence for a neuroprotective effect of lithium has accumulated over the last 2 decades, and this phenomenon has been regarded as an important mechanism of lithium action in mood disorders. It has been reflected by an increase in cerebral gray matter volume in lithium-treated subjects and by the favorable influence of lithium on cognitive functions. A neuroprotective effect of lithium also makes this ion a possible candidate for use as a therapeutic drug in neurology, especially in neurodegenerative disorders. In this paper, neurochemical mechanisms of neuroprotective action of lithium will be characterized. A possible association between the effect of lithium on brain structures reflected in neuroimaging studies, as well as on cognitive functions, and its neuroprotective action, will be considered. Data from experimental, epidemiological, and clinical studies have also pointed to an antidementia effect of lithium, bringing about some promise of using lithium in the treatment of mild cognitive impairment and Alzheimer's disease. The results of attempts of employing lithium in other neurodegenerative disorders will also be discussed. SN - 1439-0795 UR - https://www.unboundmedicine.com/medline/citation/29270949/Clinical_Perspectives_of_Lithium's_Neuroprotective_Effect_ DB - PRIME DP - Unbound Medicine ER -